Satisfaction Level of Credit Card Holders in Khulna City of Bangladesh

This study measures the satisfaction level of credit card users living in Khulna, Bangladesh. The study also examines the factors affecting their satisfaction level. Data have been collected from 50 credit card users living in Khulna city of Bangladesh through a self-administered questionnaire. After data collection, descriptive statistics (arithmetic mean, percentage) has been calculated to measure the factor-wise satisfaction level. It has been found that users are highly satisfied with the online shopping facility as well as its convenience to use. The weighted mean value of 64.16% indicates that the users are satisfied with the overall services provided by the issuers. After that Regression analysis has been used to analyze the relationship between satisfaction and the factors that affect the satisfaction. Regression statistics shows that 56.7% variation in the dependent variable (Satisfaction of the credit card users) can be explained by the independent variables used in this study whereas convenience, Online shopping facility, Benefits & rewards are found statistically significant in influencing the satisfaction of the credit card users. This research expects that the proper use of the study findings may help the credit card issuers to develop their services as well as increase customer satisfaction. Keywords: Satisfaction, Credit Card Users, Khulna City, Bangladesh

The Ways HR Professionals are Making Their Contributions in Achieving Sustainable Development Goals (SDGs)

Sustainable Development Goals (SDGs), the 2030 agenda for sustainable development, was adopted by United Nations Member States in 2015 to ensure peace, prosperity, and sustainability worldwide. Researchers from almost all the fields have been conducting SDGs related studies to contribute to this journey of the globe. For any nation, it is not possible to achieve these goals without its stakeholders' participation like policymakers, researchers, educationists, universities, government agencies, professionals, citizens, civil societies, political leaders, and so on. In this study, HR professionals have been identified as one of the stakeholders of SDGs. This study aims to explore how HR professionals are making their meaningful contributions to achieving SDGs. Secondary data from different sources have been used in this study. Through thematic and comparative analysis among the pillars of SDGs and concern areas of human resource management, this study concludes that HR professionals are making significant contributions for achieving different goals of SDGs like Good Health and Wellbeing, Quality Education, Gender Equality, Clean Water and Sanitation, Decent Work, and so on. Keywords: HR Professionals, Human Resource Management, Sustainability, Sustainable Development Goals (SDGs). DOI: 10.7176/JESD/13-7-02 Publication date: April 30th 202

The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection

SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces host genome damage and activates DNA damage response pathways. To test whether the compromised DNA repair capacity of individuals modulates the severity of COVID-19 infection, we analyze DNA repair gene expression in publicly available patient datasets and observe a lower level of the DNA glycosylase NEIL2 in the lungs of severely infected COVID-19 patients. This observation of lower NEIL2 levels is further validated in infected patients, hamsters and ACE2 receptor-expressing human A549 (A549-ACE2) cells. Furthermore, delivery of recombinant NEIL2 in A549-ACE2 cells shows decreased expression of proinflammatory genes and viral E-gene, as well as lowers the yield of viral progeny compared to mock-treated cells. Mechanistically, NEIL2 cooperatively binds to the 5'-UTR of SARS-CoV-2 genomic RNA to block viral protein synthesis. Collectively, these data strongly suggest that the maintenance of basal NEIL2 levels is critical for the protective response of hosts to viral infection and disease

The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection.

Compromised DNA repair capacity of individuals could play a critical role in the severity of SARS-CoV-2 infection-induced COVID-19. We therefore analyzed the expression of DNA repair genes in publicly available transcriptomic datasets of COVID-19 patients and found that the level of NEIL2, an oxidized base specific mammalian DNA glycosylase, is particularly low in the lungs of COVID-19 patients displaying severe symptoms. Downregulation of pulmonary NEIL2 in CoV-2-permissive animals and postmortem COVID-19 patients validated these results. To investigate the potential roles of NEIL2 in CoV-2 pathogenesis, we infected Neil2 -null ( Neil2 -/- ) mice with a mouse-adapted CoV-2 strain and found that Neil2 -/- mice suffered more severe viral infection concomitant with increased expression of proinflammatory genes, which resulted in an enhanced mortality rate of 80%, up from 20% for the age matched Neil2 +/+ cohorts. We also found that infected animals accumulated a significant amount of damage in their lung DNA. Surprisingly, recombinant NEIL2 delivered into permissive A549-ACE2 cells significantly decreased viral replication. Toward better understanding the mechanistic basis of how NEIL2 plays such a protective role against CoV-2 infection, we determined that NEIL2 specifically binds to the 5'-UTR of SARS-CoV-2 genomic RNA and blocks protein synthesis. Together, our data suggest that NEIL2 plays a previously unidentified role in regulating CoV-2-induced pathogenesis, via inhibiting viral replication and preventing exacerbated proinflammatory responses, and also via its well-established role of repairing host genome damage