8 research outputs found

    Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis

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    Objectives:To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods:A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Results:Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions:The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Representative DaTSCAN images.

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    <p>3a. DaTscan from 50 year old man with <i>GBA</i> mutation, note predominantly right sided tracer loss. 3b. DaTscan from 67 year old woman with PINK1 mutation associated Parkinson's disease, note symmetrical loss of tracer uptake in caudate heads. 3c. DaTscan from 45 year old man with Parkin mutation associated Parkinson's disease and symmetrical loss of tracer uptake. 3d. DaTscan from 32 year old man with LRRK2 mutation, note asymmetrical loss of tracer uptake in caudate heads.</p
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