Chlamydomonas reinhardtii as a new model system for studying the molecular basis of the circadian clock

AbstractThe genome of the unicellular green alga Chlamydomonas reinhardtii has both plant-like and animal-like genes. It is of interest to know which types of clock genes this alga has. Recent forward and reverse genetic studies have revealed that its clock has both plant-like and algal clock components. In addition, since C. reinhardtii is a useful model organism also called “green yeast”, the identification of clock genes will make C. reinhardtii a powerful model for studying the molecular basis of the eukaryotic circadian clock. In this review, we describe our forward genetic approach in C. reinhardtii and discuss some recent findings about its circadian clock

Development of a low-alpha-emitting {\mu}-PIC for NEWAGE direction-sensitive dark-matter search

NEWAGE is a direction-sensitive dark-matter-search experiment that uses a micro-patterned gaseous detector, or {\mu}-PIC, as the readout. The main background sources are {\alpha}-rays from radioactive contaminants in the {\mu}-PIC. We have therefore developed a low-alpha-emitting {\mu}-PICs and measured its performances. We measured the surface {\alpha}-ray emission rate of the {\mu}-PIC in the Kamioka mine using a surface {\alpha}-ray counter based on a micro TPC.Comment: 6 pages, 4 figure

論理シミュレーションとハードウェア記述言語に関する研究

京都大学0048新制・論文博士工学博士乙第7496号論工博第2471号新制||工||842(附属図書館)UT51-91-E273(主査)教授 矢島 脩三, 教授 津田 孝夫, 教授 田丸 啓吉学位規則第5条第2項該当Kyoto UniversityDFA

Synthesis of N‐{N‐[4‐(4‐{ N ‐[ 11 C]methylamino}phenyl)butyryl]‐L‐prolyl}pyrrolidine: A potential radiotracer for prolyl endopeptidase

The synthesis of the 4‐[ 11 C]methylamino derivative of N‐{N‐[4‐(4‐Aminophenyl)butyryl]‐L‐prolyl}pyrrolidine (SUAM‐1221), is described as a potential marker for prolyl endopeptidase for in vivo positron emission tomography studies. Direct methylation of the 4‐amino derivative of SUAM‐1221 ( 1 ) with methyl iodide provided a mixture of the 4‐monomethyl ( 2 ) and 4‐dimethylamino ( 3 ) derivatives which were separated by chromatography. Methylation of 1 with [ 11 C]methyl iodide provided the 4‐[ 11 C]methylamino derivative of SUAM‐1221, ([ 11 C] 2 ), in 18–30% decay corrected radiochemical yield after HPLC purification, with a specific activity > 1700 Ci/mmol and a 40 minute synthesis time from end of bombardment.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90277/1/2580340507_ftp.pd