On Myosin II dynamics in the presence of external loads

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles.Comment: 6 figures, 8 tables, to appear on Biosystem

Scalable Parallel Numerical Constraint Solver Using Global Load Balancing

We present a scalable parallel solver for numerical constraint satisfaction problems (NCSPs). Our parallelization scheme consists of homogeneous worker solvers, each of which runs on an available core and communicates with others via the global load balancing (GLB) method. The parallel solver is implemented with X10 that provides an implementation of GLB as a library. In experiments, several NCSPs from the literature were solved and attained up to 516-fold speedup using 600 cores of the TSUBAME2.5 supercomputer.Comment: To be presented at X10'15 Worksho

Addressing decision making for remanufacturing operations and design-for-remanufacture

Remanufacturing is a process of returning a used product to at least original equipment manufacturer original performance specification from the customers' perspective and giving the resultant product a warranty that is at least equal to that of a newly manufactured equivalent. This paper explains the need to combine ecological concerns and economic growth and the significance of remanufacturing in this. Using the experience of an international aero-engine manufacturer it discusses the impact of the need for sustainable manufacturing on organisational business models. It explains some key decision-making issues that hinder remanufacturing and suggests effective solutions. It presents a peer-validated, high-level design guideline to assist decision-making in design in order to support remanufacturing. The design guide was developed in the UK through the analysis of selections of products during case studies and workshops involving remanufacturing and conventional manufacturing practitioners as well as academics. It is one of the initial stages in the development of a robust design for remanufacture guideline

On the Large Time Behavior of Solutions of Hamilton-Jacobi Equations Associated with Nonlinear Boundary Conditions

In this article, we study the large time behavior of solutions of first-order Hamilton-Jacobi Equations, set in a bounded domain with nonlinear Neumann boundary conditions, including the case of dynamical boundary conditions. We establish general convergence results for viscosity solutions of these Cauchy-Neumann problems by using two fairly different methods : the first one relies only on partial differential equations methods, which provides results even when the Hamiltonians are not convex, and the second one is an optimal control/dynamical system approach, named the "weak KAM approach" which requires the convexity of Hamiltonians and gives formulas for asymptotic solutions based on Aubry-Mather sets

Scalable Parallel Numerical CSP Solver

We present a parallel solver for numerical constraint satisfaction problems (NCSPs) that can scale on a number of cores. Our proposed method runs worker solvers on the available cores and simultaneously the workers cooperate for the search space distribution and balancing. In the experiments, we attained up to 119-fold speedup using 256 cores of a parallel computer.Comment: The final publication is available at Springe

Electron Depletion Due to Bias of a T-Shaped Field-Effect Transistor

A T-shaped field-effect transistor, made out of a pair of two-dimensional electron gases, is modeled and studied. A simple numerical model is developed to study the electron distribution vs. applied gate voltage for different gate lengths. The model is then improved to account for depletion and the width of the two-dimensional electron gases. The results are then compared to the experimental ones and to some approximate analytical calculations and are found to be in good agreement with them.Comment: 16 pages, LaTex (RevTex), 8 fig

C1,αC^{1,\alpha} regularity of solutions of degenerate fully non-linear elliptic equations

In the present paper, a class of fully non-linear elliptic equations are considered, which are degenerate as the gradient becomes small. H\"older estimates obtained by the first author (2011) are combined with new Lipschitz estimates obtained through the Ishii-Lions method in order to get $C^{1,\alpha}$ estimates for solutions of these equations.Comment: Submitte

High-energy magnetic excitations in overdoped La2−x_{2-x}Srx_{x}CuO4_{4} studied by neutron and resonant inelastic X-ray scattering

We have performed neutron inelastic scattering and resonant inelastic X-ray scattering (RIXS) at the Cu-$L_3$ edge to study high-energy magnetic excitations at energy transfers of more than 100 meV for overdoped La$_{2-x}$Sr$_{x}$CuO$_{4}$ with $x=0.25$ ($T_c=15$ K) and $x=0.30$ (non-superconducting) using identical single crystal samples for the two techniques. From constant-energy slices of neutron scattering cross-sections, we have identified magnetic excitations up to ~250 meV for $x=0.25$. Although the width in the momentum direction is large, the peak positions along the (pi, pi) direction agree with the dispersion relation of the spin-wave in the non-doped La$_{2}$CuO$_{4}$ (LCO), which is consistent with the previous RIXS results of cuprate superconductors. Using RIXS at the Cu-$L_3$ edge, we have measured the dispersion relations of the so-called paramagnon mode along both (pi, pi) and (pi, 0) directions. Although in both directions the neutron and RIXS data connect with each other and the paramagnon along (pi, 0) agrees well with the LCO spin-wave dispersion, the paramagnon in the (pi, pi) direction probed by RIXS appears to be less dispersive and the excitation energy is lower than the spin-wave of LCO near (pi/2, pi/2). Thus, our results indicate consistency between neutron inelastic scattering and RIXS, and elucidate the entire magnetic excitation in the (pi, pi) direction by the complementary use of two probes. The polarization dependence of the RIXS profiles indicates that appreciable charge excitations exist in the same energy range of magnetic excitations, reflecting the itinerant character of the overdoped sample. A possible anisotropy in the charge excitation intensity might explain the apparent differences in the paramagnon dispersion in the (pi, pi) direction as detected by the X-ray scattering.Comment: 7 pages, 7 figure