94 research outputs found

    Thermodynamics of four-dimensional black objects in the warped compactification

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    We reinvestigate the thermodynamics of black objects (holes and strings) in four-dimensional braneworld models that are originally constructed by Emparan, Horowitz and Myers based on the anti-de Sitter (AdS) C-metric. After proving the uniqueness of slicing the AdS C-metric, we derive thermodynamic quantities of the black objects by means of the Euclidean formulation and find that we have no necessity of requiring any regularization to calculate their classical action. We show that there exist the Bekenstein-Hawking law and the thermodynamic first law. The thermodynamic mass of the localized black hole on a flat brane is negative, and it differs from the one previously derived. We discuss the thermodynamic stabilities and show that the BTZ black string is more stable than the localized black holes in a canonical ensemble, except for an extreme case. We also find a braneworld analogue of the Hawking-Page transition between the BTZ black string and thermal AdS branes. The localized black holes on a de Sitter brane is discussed by considering Nariai instanton, comparing the study of "black cigar" in the five-dimensional braneworld model.Comment: 15 pages, 4 figures, RevTex4, typos fixed, minor correction

    Multilevel–Multigroup Analysis Using a Hierarchical Tensor SOM Network

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    This paper describes a method of multilevel–multigroup analysis based on a nonlinear multiway dimensionality reduction. To analyze a set of groups in terms of the probabilistic distribution of their constituent member data, the proposed method uses a hierarchical pair of tensor self-organizing maps (TSOMs), one for the member analysis and the other for the group analysis. This architecture enables more flexible analysis than ordinary parametric multilevel analysis, as it retains a high level of translatability supported by strong visualization. Furthermore, this architecture provides a consistent and seamless computation method for multilevel–multigroup analysis by integrating two different levels into a hierarchical tensor SOM network. The proposed method is applied to a dataset of football teams in a university league, and successfully visualizes the types of players that constitute each team as well as the differences or similarities between the teams.23rd International Conference on Neural Information Processing, ICONIP 2016, October 16–21, 2016, Kyoto, Japa

    Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

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    ObjectivesWe examined whether distinct monocyte subsets contribute in specific ways to myocardial salvage in patients with acute myocardial infarction (AMI).BackgroundRecent studies have shown that monocytes in human peripheral blood are heterogeneous.MethodsWe studied 36 patients with primary AMI. Peripheral blood sampling was performed 1, 2, 3, 4, 5, 8, and 12 days after AMI onset. Two monocyte subsets (CD14+CD16−and CD14+CD16+) were measured by flow cytometry. The extent of myocardial salvage 7 days after AMI was evaluated by cardiovascular magnetic resonance imaging as the difference between myocardium at risk (T2-weighted hyperintense lesion) and myocardial necrosis (delayed gadolinium enhancement). Cardiovascular magnetic resonance imaging was also performed 6 months after AMI.ResultsCirculating CD14+CD16−and CD14+CD16+monocytes increased in AMI patients, peaking on days 3 and 5 after onset, respectively. Importantly, the peak levels of CD14+CD16−monocytes, but not those of CD14+CD16+monocytes, were significantly negatively associated with the extent of myocardial salvage. We also found that the peak levels of CD14+CD16−monocytes, but not those of CD14+CD16+monocytes, were negatively correlated with recovery of left ventricular ejection fraction 6 months after infarction.ConclusionsThe peak levels of CD14+CD16−monocytes affect both the extent of myocardial salvage and the recovery of left ventricular function after AMI, indicating that the manipulation of monocyte heterogeneity could be a novel therapeutic target for salvaging ischemic damage

    Simultaneous Sinus Lifting and Alveolar Distraction of a Severely Atrophic Posterior Maxilla for Oral Rehabilitation with Dental Implants

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    We retrospectively reviewed a new preimplantation regenerative augmentation technique for a severely atrophic posterior maxilla using sinus lifting with simultaneous alveolar distraction, together with long-term oral rehabilitation with implants. We also analyzed the regenerated bone histomorphologically. This study included 25 maxillary sinus sites in 17 patients. The technique consisted of alveolar osteotomy combined with simultaneous sinus lifting. After sufficient sinus lifting, a track-type vertical alveolar distractor was placed. Following a latent period, patient self-distraction was started. After the required augmentation was achieved, the distractor was left in place to allow consolidation. The distractor was then removed, and osseointegrated implants (average of 3.2 implants per sinus site, 80 implants) were placed. Bone for histomorphometric analysis was sampled from six patients and compared with samples collected after sinus lifting alone as controls (n=4). A sufficient alveolus was regenerated, and all patients achieved stable oral rehabilitation. The implant survival rate was 96.3% (77/80) after an average postloading followup of 47.5 months. Good bone regeneration was observed in a morphological study, with no significant difference in the rate of bone formation compared with control samples. This new regenerative technique could be a useful option for a severely atrophic maxilla requiring implant rehabilitation

    Pathological Investigation of Congenital Bicuspid Aortic Valve Stenosis, Compared with Atherosclerotic Tricuspid Aortic Valve Stenosis and Congenital Bicuspid Aortic Valve Regurgitation

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    Congenital bicuspid aortic valve (CBAV) is the main cause of aortic stenosis (AS) in young adults. However, the histopathological features of AS in patients with CBAV have not been fully investigated.We examined specimens of aortic valve leaflets obtained from patients who had undergone aortic valve re/placement at our institution for severe AS with CBAV (n = 24, CBAV-AS group), severe AS with tricuspid aortic valve (n = 24, TAV-AS group), and severe aortic regurgitation (AR) with CBAV (n = 24, CBAV-AR group). We compared the histopathological features among the three groups. Pathological features were classified using semi-quantitative methods (graded on a scale 0 to 3) by experienced pathologists without knowledge of the patients' backgrounds. The severity of inflammation, neovascularization, and calcium and cholesterol deposition did not differ between the CBAV-AS and TAV-AS groups, and these four parameters were less marked in the CBAV-AR group than in the CBAV-AS (all p<0.01). Meanwhile, the grade of valvular fibrosis was greater in the CBAV-AS group, compared with the TAV-AS and CBAV-AR groups (both p<0.01). In AS patients, thickness of fibrotic lesions was greater on the aortic side than on the ventricular side (both p<0.01). Meanwhile, thickness of fibrotic lesions was comparable between the aortic and ventricular sides in CBAV-AR patients (p = 0.35).Valvular fibrosis, especially on the aortic side, was greater in patients with CBAV-AS than in those without, suggesting a difference in the pathogenesis of AS between CBAV and TAV

    Reference values for the locomotive syndrome risk test quantifying mobility of 8681 adults aged 20–89 years: A cross-sectional nationwide study in Japan

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    Background The locomotive syndrome risk test was developed to quantify the decrease in mobility among adults, which could eventually lead to disability. The purpose of this study was to establish reference values for the locomotive syndrome risk test for adults and investigate the influence of age and sex. Methods We analyzed 8681 independent community dwellers (3607 men, 5074 women). Data pertaining to locomotive syndrome risk test (the two-step test, the stand-up test, and the 25-question geriatric locomotive function scale [GLFS-25]) scores were collected from seven administrative areas of Japan. Results The reference values of the three test scores were generated and all three test scores gradually decreased among young-to-middle-aged individuals and rapidly decreased in individuals aged over 60 years. The stand-up test score began decreasing significantly from the age of 30 years. The trajectories of decrease in the two-step test score with age was slightly different between men and women especially among the middle-aged individuals. The two physical test scores were more sensitive to aging than the self-reported test score. Conclusion The reference values generated in this study could be employed to determine whether an individual has mobility comparable to independent community dwellers of the same age and sex

    Dives of cruising-AUV "JINBEI" to methane hydrate area on Joetsu knoll and Umitaka Spur

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    Autonomous Underwater Vehicle "JINBEI", constructed in 2012, is a cruising type AUV with a weight of 2 ton and a length of 4.0m. The major purposes are observation of underwater CO2 distribution in deep sea and exploration of seabed mineral resources. It has four rear-thrusters, two mid-ship azimuthal thrusters, and a rear X-rudder. The AUV is equipped with three main sensors; a multi-beam echo sounder, a side scan sonar, and a hybrid CO2-pH sensor. During KY12-10 cruise in August 2012, we deployed "JINBEI" at a methane hydrate area in Joetsu knoll and Umitaka Spur, Japan Sea. The depth of the area is 850-950m. The vehicle cruised over the methane hydrate area at a speed of 2 knots. We obtained high-resolution side scan images of hydrate mounts as well as methane plumes. At same time, the CO2-pH sensor detected the methane plumes indirectly. Through the dives, we confirmed that the cruising AUV "JINBEI" is one of powerful tool for survey of scientific observations.Date of Conference: 23-27 September 2013http://www.godac.jamstec.go.jp/darwin/cruise/kaiyo/ky12-10/
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