Thermal cycloaddition of tetraphenylcyclopentadienone to allenic esters: Investigations on peri-, regio-, and stereo-selectivities

742-74

Investigations on photochemistry of α-allenic ketones: Interception of a polarized excited state through methanol addition

643-645n→π<span dir="RTL" style="font-size:12.0pt; font-family:" times="" new="" roman";color:#121212;mso-bidi-language:ar-sa"="" lang="AR-SA">٭ Excitation (pyrex glass reactor) of α-allenic ketones leads to population of a polarized excited state of allenic moiety which has been intercepted, in high turnover, by methanol addition.</span

NMR and X-ray characterization of the diastereomeric pinacols derived from the photo-irradiation of <i>o</i>-alkoxyacetophenones

506-509A simple 1H NMR characterization of diastereomeric pinacols derived from o-alkoxy-acetophenones is described. The 1H NMR spectral assignments are based on molecular modeling and substantiated by X-ray crystallographic structural assignment of a diastereomer

Investigations on photochemical linking of steroids with amino acids: Irradiation of α, β-unsaturated steroidal ketones in the presence of amino acids in aqueous medium

1253-1261  Irradiation of 1, 4-cholestadien-3-one 1 in THF-H2O solvent in the presence of amino acids (glycine/alanine) leads to dienone-phenol photo rearrangement products, 3-hydroxy-l-methyl-19-norcholesta-1, 3, 5 (10) -triene 3 (35%), 4-hydroxy- 2-methyl-19-nor-cholesta-1, 3, 5 (10) -triene <b style="mso-bidi-font-weight: normal">4 (15%), 1-hydroxy-4-methyl-19-norcholesta-1, 3, 5 (10)-triene <b style="mso-bidi-font-weight: normal">5 (28%) along with a novel methyl substituted-19-norcholesta-1, 3, 5 (10)-triene 6 and a spirocyclic-enone 7; no amino acid or solvent addition product is obtained. Irradiation of 16-dehydropregnenolone-3β-acetate 2 under identical conditions in the presence of glycine affords the pregnenolone-3β -acetate <b style="mso-bidi-font-weight: normal">9 (25%), 16-(tetrahydrofuran-2-yl) -pregnenolone-3β-acetate 10 and its 17- α-isomer 11 (together 35%) and 16-(glycin-2-yl) -pregnenolone-3β-acetate 12 (mixture of isomers, 25%). The results are compared and contrasted with known photochemical behaviour of steroidal enones and dienones. The studies indicate that steroidal-16-ene-20-ones can be better photoaffinity labelling agents for progestogen and possibly, adrenal steroidal receptors. Also, the photochemical additions to ∆16-20-one steroidal systems can be exploited for the introduction of substituents/moieties at C16 in steroids.</span

Phototransformation of 16⍺,17 ⍺-epoxy-3β-hydroxypregn- 5-ene-20-one to 3β-hydroxypregn-5-ene-16,20-dione

192-194UV irradiation of 16⍺,17⍺-epoxy-3β-hydroxypregn-5-ene-20-one 5 in a variety of solvents (benzene, acetonitrile, methanol), as such and in the presence of triethylamine, in a pyrex glass reactor leads to the formation of 3β-hydroxypregn-5-ene-16,20-dione 6 as the major product

<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Effect of <i style="mso-bidi-font-style:normal">Aegle marmelos</i> (L.) Correa on alloxan induced early stage diabetic nephropathy in rats</span>

464-469Diabetic nephropathy (DN) has a complex pathogenesis and poor prognosis due to the lack of therapeutic interventions. The present study investigates the effect of A. marmelos leaf extract (AME) on early alloxan induced DN. The treatment with AME was found to significantly decrease the fasting blood sugar, total cholesterol, blood urea, creatinine and renal TBARS and increased the levels of renal reduced glutathione and catalase significantly as compared to the diabetic control group. The maximum dose-dependent protection was observed at a dose of 200 mg kg-1. Histological examination revealed marked reversal of the morphological derangements with AME treatment as indicated by a decrease in glomerular expansion, tubular dilatation and inflammatory cells. The present results conclude that AME treatment has a significant ameliorative effect on early changes induced in the kidneys by alloxan and improves the outcome of DN