79 research outputs found
Concomitant Carcinoma in situ in Cystectomy Specimens Is Not Associated with Clinical Outcomes after Surgery
Objective: The aim of this study was to externally validate the prognostic value of concomitant urothelial carcinoma in situ (CIS) in radical cystectomy (RC) specimens using a large international cohort of bladder cancer patients. Methods: The records of 3,973 patients treated with RC and bilateral lymphadenectomy for urothelial carcinoma of the bladder (UCB) at nine centers worldwide were reviewed. Surgical specimens were evaluated by a genitourinary pathologist at each center. Uni- and multivariable Cox regression models addressed time to recurrence and cancer-specific mortality after RC. Results: 1,741 (43.8%) patients had concomitant CIS in their RC specimens. Concomitant CIS was more common in organ-confined UCB and was associated with lymphovascular invasion (p < 0.001). Concomitant CIS was not associated with either disease recurrence or cancer-specific death regardless of pathologic stage. The presence of concomitant CIS did not improve the predictive accuracy of standard predictors for either disease recurrence or cancer-specific death in any of the subgroups. Conclusions: We could not confirm the prognostic value of concomitant CIS in RC specimens. This, together with the discrepancy between pathologists in determining the presence of concomitant CIS at the morphologic level, limits the clinical utility of concomitant CIS in RC specimens for clinical decision-making. Copyright (C) 2011 S. Karger AG, Base
A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer
Study of testosterone as a predictor of tumor aggressiveness in patients with prostate cancer
Prospektive Untersuchung zur Prädiktion von Harnsäuresteinen mittels Dual-Energy CT der dritten Generation und mögliche Pitfalls
504 STAGE-PER-STAGE ANALYSIS OF AGE AND CANCER- SPECIFIC MORTALITY (CSM) IN PATIENTS WITH RENAL CELL CARCINOMA (RCC): A RETROSPECTIVE ANALYSIS
668 A COMPARATIVE SURVIVAL ANALYSIS OF ADENOCARCINOMA VS. TRANSITIONAL CELL CARCINOMA AFTER RADICAL CYSTECTOMY
866 Modified Y/V-plasty for the treatment of recurrent bladder neck contracture: Outcome and patient satisfaction
1097 Oncologic outcome after active treatment in men initially on active surveillance: Impact of population-based screening on prostate cancer progression. The experience of the Swiss arm of the ERSPC
667 BLADDER CANCER STAGE DISTRIBUTION AT RADICAL CYSTECTOMY IN THE LAST TWO DECADES IN A POPULATION-BASED COHORT
Residual pathologic stage at radical cystectomy and risk stratification of patients with pT2N0 bladder cancer
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