Evaporation induced flow inside circular wells

Flow field and height averaged radial velocity inside a droplet evaporating in an open circular well were calculated for different modes of liquid evaporation.Comment: 5 page, 3 figures, submitted to European Physical Journal

OCTA-based retinal microvascular bed assessment at the zones ranging from the fovea to the periphery

Background: Studies (particularly, optical coherence tomography angiography (OCTA) studies) on the peripheral microvascular bed in health are important because many retinal disorders involve its injury. Purpose: To improve the efficacy of diagnosing the changes in the retinal microvascular bed through its OCTA-based assessment at the zones ranging from the fovea to the periphery in normal eyes. Material and Methods: Fourteen healthy individuals were included in the study. Three sequential 3 mm x 3 mm OCTA scans with displacement from the center of the fovea to the periphery for each of the three directions (superior, inferior and temporal directions) were registered. Results: Superficial plexus vessel density and deep plexus vessel density were assessed at 1-9 mm from the center of the fovea. We found that superficial plexus vessel density progressively increased (38-46%) with distance from the center of the fovea, whereas deep plexus vessel density moderately decreased (18-25%) with distance from the center. Superficial plexus vessel density was significantly increased in the superior and inferior directions at the zones with the presence of vascular arcades, and these arcades are absent in the temporal direction; this makes the temporal direction most reliable and promising for studies on microcirculation at the ocular periphery. Conclusion: OCTA is an effective technique for assessing the retinal microvascular bed at the zones ranging from the fovea to the far periphery

CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS AND SOME CYTOKINES IN BLOOD OF WOMEN DURING MENOPAUSAL THERAPY

It has been shown that the influence of hormonal and non-hormonal therapy of menopausal syndrome upon immune profile may be variable, and the results of appropriate studies may be often contradictory. The aim of this work was to investigate the influence of hormonal and non-hormonal therapy in menopausal syndrome upon serum levels of some immunoregulatory proteins, i.e., alpha2-macroglobulin (a2-MG), pregnancy-associated alpha 2-glycoprotein (PAG), contents of some related cytokines (IL-6, IL-8, TNFα, IFNγ, IL-2) as well as VEGF amounts. Administration of menopausal hormone treatment and nonhormonal therapy was associated with reduced IL-6 levels in serum, regardless of treatment duration, or type of drug applied. We have found a statistically significant decrease of IL-8 serum levels in the course of dynamic monitoring in the women taking a menopausal hormone preparation containing 1 mg of 17β-estradiol and 5 mg dydrogesterone, and a non-hormonal drug containing genistein (60 mg) for 3-6 months. The levels of VEGF demonstrated high individual variability during therapy of menopausal syndrome. Serum concentrations of immunoregulatory a2-MG were stable in climacteric syndrome, and did not differ from normal values. However, the content of PAG, a known immunosuppressive protein, was increased 3-4 times in serum of 33-50% of the women receiving menopausal hormonal therapy, regardless of progestogen dose (5 or 10 mg dydrogesterone), and duration of its use. These findings suggest a need for individualized drug selection in order to minimize a risk of immunodeficiency conditions in the patients receiving hormone therapy of menopausal syndrome

Dynamic observation of patients with hyperglycemia and hypercholesterolemia in clinical practice

The article deals the detection of increased levels of glucose and blood cholesterol following the results of medical examination by patients, the frequency of establishing appropriate diagnoses, as well as the availability of further observations of these indicators in various groups of patients.В статье рассмотрена выявляемость повышения уровней глюкозы и общего холестерина крови по итогам прохождения пациентами всеобщей диспансеризации, частота установления соответствующих диагнозов, а также наличие дальнейшего наблюдения за этими показателями у различных групп пациентов

Antimicrobial resistance in clinical <I>Escherichia coli</I> isolates obtained from animals

The article presents data on the phenotypic and genotypic characteristics of antimicriobial resistance in Escherichia coli clinical isolates recovered from bovine microbiota (secretions from mammary glands, cervical swabs). 127 Escherichia coli isolates were studied, i.e. 44 from mammary glands secretions and 83 from cervical swabs. Disk diffusion method was used to study antimicrobial resistance of the cultures; minimum inhibitory concentrations of antimicrobials were determined in a serial dilution method; resistance genes were detected by polymerase chain reaction. The carried out research demonstrates a wide distribution of the isolates belonging to the phenotype resistant to ansamycins (rifampicin), semi-synthetic penicillins (ampicillin and amoxicillin), tetracyclines (doxycycline). The isolates showed a lower level of resistance to macrolides (azithromycin), amphenicols (levomycetin) and aminoglycosides (tobramycin). It was found that Escherichia coli clinical isolates are sensitive to third-generation cephalosporins and fluoroquinolone antimicrobials. However, since 28.46% of cultures demonstrate intermediate resistance to third-generation cephalosporins and 49.02% of Escherichia coli DNA samples isolated from mammal gland secretions had blaDHA gene associated with resistance to this group of antimicrobials, these antimicrobials could be hardly recommended as antibiotics of choice. Absence of VIM carbapenemase-encoding gene in the DNA of the recovered isolates and a low level of phenotypic resistance (10.22% of isolates from cervical swabs) can be one of the reasons for recommending first-line carbapenems as antibiotics of choice to treat animal diseases associated with Escherichia coli, along with fluoroquinolones as reserve antimicrobials. It was found that the recovered Escherichia coli isolates are more sensitive to combination antibiotics than to mono-antibiotics

Peculiarities of epidemiological process incidence of measles in MO Ekaterinburg and the general incidence of measles in Russia

The article considers the chronology of measles outbreaks in the city of Yekaterinburg against the background of indicators in the Russian Federation over the past 19 years, in order to draw attention to the importance of timely prevention of the disease.В статье рассмотрена хронология вспышек заболеваемости корью в МО город Екатеринбург на фоне показателей в РФ за последние 19 лет, с целью привлечения внимания к важности своевременной профилактики заболевания

Матричный синтез полианилина в присутствии полимерной сульфокислоты

It was investigated the influence of the correlation of sulfoacid and aniline concentration on the polymerization of the latter when it was protonated by polymeric sulfoacid and on electronic structure of forming polyaniline.Исследовано влияние соотношения концентраций сульфокислотных групп и анилина на полимеризацию последнего при его протонировании по- лимерной сульфокислотой и электрон- ную структуру образующегося полиани- лина

Relationship of depressive disorders with hypertension, its control and other metabolic risk factors in the Tyumen Oblast population of men and women. Data from the study “Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation” (ESSE-RF)

Aim. To study the association between depression and metabolic cardiovascular risk factors, hypertension (HTN) and its control in a random sample of Tyumen Oblast population of men and women aged 25-64 years.Material and methods. The study object was a random sample of the population of the Tyumen and the Tyumen Oblast aged 25-64 years, examined as part of the ESSE-RF epidemiological study. The study included 1658 participants. Among them, 30,3% (n=503) were men, while 69,7% (n=1155) — women. Mean age was 48,9±11,4 years. The prevalence of metabolic risk factors (hyperlipidemia, carbohydrate metabolism disorder, obesity), hypertension and the likelihood of its control in men and women with different levels of depressive disorders diagnosed using the HADS scale were assessed.Results. Compared with participants without depression, persons with psychological disorders were significantly more likely to have HTN (55,5% vs 47,6%, p&lt;0,01), elevated levels of total cholesterol (TC) (63,9% vs 54,0%, p&lt;0,01) and low-density lipoproteins (LDL) (66,7% vs 60,3%, p&lt;0,05), carbohydrate metabolism disorders (8,3% vs 5,2% p&lt;0,05), obesity (49,2% vs 37,7%, p&lt;0,01). Significantly more often hypertensive subjects without depression took antihypertensive drugs effectively (odds ratio (OR) — 1,747, 95% confidence interval (CI), 1,001-3,053) and controlled blood pressure (OR — 1,533, 95% CI, 1,05-2,36). There was no association between the use of antihypertensives and the level of depressive disorders. Among women with depression (HADS&gt;7), dyslipidemia (65,5% vs 57,4% for TC, p&lt;0,05; 71,0% vs 62,9% for LDL, p&lt;0,05), carbohydrate metabolism disorders (10,1% vs 5,2%, p&lt;0,01), obesity (53,3% vs 43,2%, p&lt;0,01), HTN (60,6% vs 45,6%, p&lt;0,01) were more common. Men with clinical depression were more likely to have HTN (69,0% vs 47,7%, p&lt;0,05), with a high level of depression — hyperlipidemia (58,9% vs 46,7% for TC, p&lt;0,05; 67,1% vs 53,9% for LDL, p&lt;0,05). Women with elevated depression levels were less likely to take antihypertensive drugs (30% vs 49,4%, p&lt;0,01) and control hypertension (13,8% vs 21,2%, p&lt;0,05).Conclusion. The data obtained confirm the association of depressive disorders with metabolic risk factors and the likelihood of HTN control, which is especially significant among women

Risk assessment of cardiovascular diseases of USMU stuff

Article describes statistical data, which were received during measurement the lipid spectrum of Ural State Medical University staff.В статье описаны статистические данные, полученные при исследовании липидного спектра и оценки рисков сердечно-сосудистых заболеваний у сотрудников Уральского государственного медицинского университета