Summary of samples used in epidemiological and genetic analyses.

<p>For epidemiological analyses, presented are the number of data points (observations and calculated mean/max values) analyzed for each phenotype category, the corresponding number of individuals implicated and hence residual values generated. For genetic analyses, presented are the number of these individuals for whom pedigree information was available and thus the number of independent families and relative pairs count for each phenotype in the heritability analyses. In parentheses, the number belonging to the large complex family.</p

Contribution (%) of genetic (heritability, h²) and house (c²) effects to variability in malaria and non-malaria clinical and biological phenotypes of <i>P. falciparum</i> (Pf) and <i>P. vivax</i> (Pv).

<p>h², variance due to genetics, c², variance due to house effect, S.E. the standard error; NS, not significant (<i>p-value</i>>0.05); NE, not estimated.</p>a<p>Retained because of marginal significance.</p

Pair-wise correlation between phenotypes studied.

<p>PFA, Number of visits Pf+; NMF, Number of non-malaria fever visits; PVA, Number of visits Pv+; mx-PFD, Pf max parasite density; PFD, Overall Pf parasite densities; mx-PVD, Pv max parasite density; PVD, Overall Pv parasite densities. In bold, highly significant p value (≤10⁻⁴); in italic, significant p value that becomes not significant after Bonferroni correction for multiple testing (21 hypotheses tested).</p

Proportions of variation explained by genetic heritability, house and environmental factors found to have a significant effect on the phenotype measured (Table 3&6).

<p>(A) Number of clinical episodes of <i>P. falciparum</i> (PFA); (B) Number of clinical episodes of <i>P. vivax</i> (PVA); (C) Number of non-malaria clinical episodes (NMF); (D) Maximum <i>P. falciparum</i> parasite density (mx-PFD); (E) Overall <i>P. falciparum</i> parasite density (PFD); (F) Maximum <i>P. vivax</i> parasite density (mx-PVD); (G) Overall <i>P. vivax</i> parasite density (PVD). Values of 1% or less not indicated numerically in the figure.</p

Family statistics.

<p>Family statistics.</p

Number of pairs of individuals as defined by genetic relationship (phi2) and household relationship.

<p>Number of pairs of individuals as defined by genetic relationship (phi2) and household relationship.</p

Percentage of variation in <i>P. falciparum</i> (Pf) and <i>P. vivax</i> (Pv) phenotypes explained by environmental factors (and their interactions) in the statistical analyses.

<p>In parentheses, <i>p</i> is the <i>p-value</i>; in bold, <i>p-value</i><10⁻³.</p>a<p>Retained because of significant interaction with Age.</p

Confocal imaging of PPP2R5E and NS5 from DENV1 and DENV2.

<p>A. The main link motifs in NS5 proteins from DENV1 and DENV2. B. Subcellular localization of PPP2R5E in Huh7 control cells. C. Subcellular localization of PPP2R5E in Huh7 control and after 24h, 48h and 72h of transfection with DENV2-NS5 protein. D. Subcellular localization of mutated PPP2R5E in Huh7 control and after 24h, 48h and 72h of transfection with DENV2-NS5 protein. E. Subcellular localization of PPP2R5E in Huh7 control and after 24h, 48h and 72h of transfection with DENV1-NS5 protein. Green immunofluorescence indicates PPP2R5E, red indicates NS5, blue flags nucleus. Yellow signals indicate co-localization of NS5 and PPP2R5E, and was obtained by overlapping the two panels. Original magnification, ×630.</p

Worldwide (from the 1000 Genomes database) and Thai dengue cohorts (control, DF and DSS) frequencies for significantly associated haplotypes in the various genes.

<p>A- <i>PLCB4</i>; B- <i>PLCE1</i>; C- <i>MICB</i>; D- <i>CHST10</i>; E- <i>AHRR</i>; F- <i>GRIP1</i>; G- <i>PPP2R5E</i>. The protective and causative haplotypes are highlighted.</p

Global ancestry inferred through RFMix when using three parental ancestries (South, Northeast and Southeast Asian) for the global dataset.

<p>Each vertical line represents an individual, and the three colours represent the proportion of the three parental populations in each genome (light orange for South Asian, dark orange for Southeast Asian and blue for Northeast Asian).</p