Schistosoma mansoni infection and nutritional status in schoolchildren: a randomized, double-blind trial in northeastern Brazil1–3

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2016-06-28T18:59:50Z No. of bitstreams: 1 Assis AMO Schistosoma mansoni...pdf: 142629 bytes, checksum: 779640530219f18adf3cbccf68a80a26 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2016-06-28T19:10:42Z (GMT) No. of bitstreams: 1 Assis AMO Schistosoma mansoni...pdf: 142629 bytes, checksum: 779640530219f18adf3cbccf68a80a26 (MD5)Made available in DSpace on 2016-06-28T19:10:42Z (GMT). No. of bitstreams: 1 Assis AMO Schistosoma mansoni...pdf: 142629 bytes, checksum: 779640530219f18adf3cbccf68a80a26 (MD5) Previous issue date: 1998Made available in DSpace on 2016-07-07T11:39:46Z (GMT). No. of bitstreams: 3 Assis AMO Schistosoma mansoni...pdf.txt: 38667 bytes, checksum: c8a093d5a65be0dc45b84a9889eb36de (MD5) Assis AMO Schistosoma mansoni...pdf: 142629 bytes, checksum: 779640530219f18adf3cbccf68a80a26 (MD5) license.txt: 2991 bytes, checksum: 5a560609d32a3863062d77ff32785d58 (MD5) Previous issue date: 1998Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, BrasilFederal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, BrasilFederal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilCase Western Reserve University School of Medicine. Department of Nutrition and Division of Geographic Medicine. ClevelandBrazilian schoolchildren with mild- to moderate- intensity schistosome infections (< 400 Schistosoma mansoni eggs/g stool) were randomly allocated to a treatment (oxamniquine) or placebo group in a double-blind fashion. Anthropometric measurements were made at baseline, 6 mo, and 1 y for 353 students. At baseline, the groups were not significantly different with respect to nutritional status or selected socioeconomic and biological characteristics, including anthropometric measures. One year later, significant differences were noted only in the nutritional status of boys treated for schistosome infection. Treated boys had greater measurements for weight, triceps skinfold thickness, midarm circumference, arm muscle area, and body mass index than untreated boys. They also showed significant increases over the year in weight, height, midarm circumference, and body mass index. The rates of improvement in weight and height were more accelerated in the first 6 mo after therapy than the last. These results indicate that, at least in boys, chronic S. mansoni infection at any intensity is detrimental to short-term growth and developmen

Fatores de risco para anemia por deficiência de ferro em crianças e adolescentes parasitados por helmintos intestinais / Risk factors for iron-deficiency anemia in children and adolescents with intestinal helminthic infections

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2012-12-13T20:25:35Z No. of bitstreams: 1 Brito, Luciara L Fartores de risco....pdf: 96242 bytes, checksum: 7289ba428468e217a786b8b814b037da (MD5)Made available in DSpace on 2012-12-13T20:25:35Z (GMT). No. of bitstreams: 1 Brito, Luciara L Fartores de risco....pdf: 96242 bytes, checksum: 7289ba428468e217a786b8b814b037da (MD5) Previous issue date: 2003Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Nutrição. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Nutrição. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilCase Western Reserve University. Departamento de Nutrição. Cleveland, Ohio, Estados UnidosCase Western Reserve University. Divisão de Medicina Geográfica. Cleveland, Ohio, Estados UnidosInvestigar os fatores de risco para anemia por deficiência de ferro em crianças e adolescentes (7 a 17 anos) infectados por helmintos. MÉTODOS: Foi realizado um estudo transversal com 1709 crianças e adolescentes residentes na cidade de Jequié, Estado da Bahia, Brasil, que apresentavam infecçäo leve ou moderada por Schistosoma mansoni, Ascaris lumbricoides, Trichuris trichiura e ancilostomídeos. Foram obtidos dados sobre níveis de hemoglobina (hemoglobinômetro portátil), consumo alimentar (inquérito recordatório de 24 horas), infecçäo parasitária (método Kato-Katz), condiçöes ambientais e domiciliares, renda e escolaridade dos responsáveis. Os fatores de risco para anemia na populaçäo foram estudados com base em um modelo hierárquico de causalidade. RESULTADOS: A prevalência de infecçäo por T. trichiura, A. lumbricoides, S. mansoni e ancilostomídeos foi de 74,8, 63,0, 55,5 e 15,7 por cento, respectivamente. Constatou-se que 32,2 por cento das crianças e adolescentes eram anêmicos. Depois do ajuste para variáveis de confusäo, os resultados da análise multivariada mostraram que a renda familiar per capita abaixo de um quarto do salário mínimo (27 dólares), o sexo masculino, a faixa etária de 7 a 9 anos e a ingestäo inadequada de ferro biodisponível foram significativamente associados à anemia. CONCLUSÖES: As açöes para controle da anemia no grupo de maior risco, conforme identificado no presente estudo, devem visar o aumento do consumo de alimentos ricos em ferro e da biodisponibilidade do ferro ingerido, bem como a melhoria das condiçöes sócio-ambientais

Moderate- and low-intensity co-infections by intestinal helminths and Schistosoma mansoni, dietary iron intake, and anemia in Brazilian children.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-04-28T17:42:23Z No. of bitstreams: 1 Brito LL Moderate and low-intensity.....pdf: 93984 bytes, checksum: 9f990ce3893a32746fa9b44ecd79d83f (MD5)Made available in DSpace on 2014-04-28T17:42:23Z (GMT). No. of bitstreams: 1 Brito LL Moderate and low-intensity.....pdf: 93984 bytes, checksum: 9f990ce3893a32746fa9b44ecd79d83f (MD5) Previous issue date: 2006Federal University of Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFederal University of Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Nutrição. Departamento de Ciência da Nutrição. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Nutrição. Departamento de Ciência da Nutrição. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilDepartment of Nutrition. Case Western Reserve University School of Medicine. Cleveland, OHCenter for Global Health and Disease. Case Western Reserve University School of Medicine. Cornell, Cleveland, OHTo determine the role of moderate- and low-intensity infections with Schistosoma mansoni and intestinal helminths (hookworm, Trichuris trichiura, Ascaris lumbricoides) on the prevalence of anemia and their relationship to iron consumption, a cross-section of 1,709 children in rural Brazil was studied. All participants were selected for infection with one or multiple helminthic parasites, and demographic, anthropometric, and dietary intake were surveyed. The prevalence and intensity were as follows: hookworm infection, 15.7% and 8.6 eggs/g; T. trichiura, 74.8% and 190.5 eggs/g; A. lumbricoides, 63% and 1,905.5 eggs/g; S. mansoni, 44.5% and 60.3 eggs/g. There was no increase in odds ratio for anemia with any combination of intestinal helminths without S. mansoni infection. By logistic regression, the odds ratio for having anemia when infected with S. mansoni and two intestinal helminths was 1.7 (95% CI, 1.1–2.5) and for S. mansoni and three intestinal helminths was 2.4 (95% CI, 1.2–4.6) compared with children with a single parasite species. Children with an adequate intake of iron had no increased odds of anemia independent of the combination of parasite infections

Childhood stunting in Northeast Brazil: the role of Schistosoma mansoni infection and inadequate dietary intake

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-04-30T13:30:51Z No. of bitstreams: 1 Assis AM Childhood stunting....pdf: 116763 bytes, checksum: 54f319b435f895ebc812cba827545b82 (MD5)Made available in DSpace on 2014-04-30T13:30:51Z (GMT). No. of bitstreams: 1 Assis AM Childhood stunting....pdf: 116763 bytes, checksum: 54f319b435f895ebc812cba827545b82 (MD5) Previous issue date: 2004Federal University of Bahia. The School of Nutrition. Salvador, BA, Brasil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil.Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Federal University of Bahia. The School of Nutrition. Salvador, BA, Brasil.Department of Nutrition. Case Western Reserve University. Cleveland, OH, USA.Center for Global Health and Diseases. Case Western Reserve University. Cleveland, OH, USA.OBJECTIVE: To evaluate the relationship between stunting, Schistosoma mansoni infection and dietary intake in schoolchildren. DESIGN: This is a cross-sectional study. Two stool samples were obtained from each child and examined quantitatively for the presence of S. mansoni, Ascaris lumbricoides and Trichuris trichiuria eggs. Information on dietary intake, and demographic, biologic and socioeconomic variables was elicited during the in-home survey. Logistic regression was used to evaluate the association between stunting (height for age or = 400 eggs/g of stool) with S. mansoni had a 2.74-fold (95% CI: 1.32-5.67) higher risk of stunting than uninfected children, and those with inadequate intake of lipid (< 36 g/day) had a 1.83-fold (95% CI: 1.05-3.20) increased risk of stunting compared to those with adequate diets. CONCLUSION: Heavy S. mansoni infection and inadequate dietary intake of fat in schoolchildren play a significant and independent role in the development of stunting. This meaning that nutritional interventions in this age group in S. mansoni endemic areas must include the diagnosis and treatment of the infection associated with dietary measures. SPONSORSHIP: This study was supported by the Thrasher Foundation. Sandra Maria Conceição Pinheiro is a National Council on Technological Development Scholarship Awardee (CNPq), #302228/81-0

The relative influence of polyparasitism, environment, and host factors on schistosome infection.

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-04-25T17:29:11Z No. of bitstreams: 1 Silva RCR The relative.....pdf: 138357 bytes, checksum: bcc85d6dc499f41486d58af27a93da93 (MD5)Made available in DSpace on 2014-04-25T17:29:11Z (GMT). No. of bitstreams: 1 Silva RCR The relative.....pdf: 138357 bytes, checksum: bcc85d6dc499f41486d58af27a93da93 (MD5) Previous issue date: 2007Federal University of Bahia.School of Nutrition. Salvador, BA, BrasilFederal University of Bahia. Institute of Collective Health. Salvador, BA, BrasilFederal University of Bahia.School of Nutrition. Salvador, BA, BrasilFederal University of Bahia.School of Nutrition. Salvador, BA, BrasilDepartment of Nutrition. Case Western Reserve University. Cleveland, OH, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilCenter for Global Health and Diseases. Case Western Reserve University. Cleveland, OH, USAWhere prevalence of geohelminths and schistosomes is high, co-infections with multiple parasite species are common. Previous studies have shown that the presence of geohelminths either promotes or is a marker for greater prevalence and intensity of Schistosoma mansoni infections. Some of this apparent synergy may simply represent shared conditions for exposure, such as poor sanitation, and may not suggest a direct biologic interaction. We explored this question in a study of 13,279 school children in Jequié, Bahia, Brazil, with a survey of demographic characteristics and stool examinations. Cross-sectional analysis revealed a statistically significant increase in the prevalence and intensity of S. mansoni infection with increasing numbers of geohelminth species (OR 2.5, 95% CI 1.38–3.64). Less than 20% of the strength of this association was contributed by socioeconomic status or environmental conditions. Thus, polyparasitism itself, as well as intrinsic host factors, appears to produce greater susceptibility to additional helminth infections

Association between stunting and developmental delay in helminth-infected children and adolescents

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2012-12-13T19:20:27Z No. of bitstreams: 1 Alves, Thaisy Cristina Honorato Santos et al. Associação entre déficit....pdf: 346067 bytes, checksum: 3e15fe4558de24888c49785a6887a1a7 (MD5)Made available in DSpace on 2012-12-13T19:20:27Z (GMT). No. of bitstreams: 1 Alves, Thaisy Cristina Honorato Santos et al. Associação entre déficit....pdf: 346067 bytes, checksum: 3e15fe4558de24888c49785a6887a1a7 (MD5) Previous issue date: 2009Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Case Western Reserve University. Department of Nutrition. Cleveland, Ohio, USA.Case Western Reserve University. Center for International Health and Disease. Cleveland, OH, USA.Avaliar a influência do déficit de crescimento sobre o retardo maturacional de crianças e adolescentes com infecção helmíntica. MÉTODOS: Trata-se de um estudo transversal, em que participaram 1 764 indivíduos de 7 a 17 anos de idade, de ambos os sexos, infectados por Schistosoma mansoni isoladamente ou Schistosoma mansoni associado a geohelmintos, residentes na cidade de Jequié (BA). Os participantes foram submetidos a avaliação antropométrica, dos estágios de desenvolvimento puberal e a exame parasitológico de fezes. Foram coletadas informações referentes às condições sanitárias do domicílio e socioeconômicas da família. Optou-se pela análise de regressão logística multivariada para as análises estatísticas de interesse. RESULTADOS: Os resultados deste trabalho mostraram uma prevalência de 15,4 por cento de déficit estatural entre os integrantes do estudo. O déficit de crescimento físico associou-se ao atraso da puberdade (0R=4,01; IC95 por cento1,01-15,8). Esta associação pode ser explicada pelo impacto negativo que a desnutrição exerce sobre a produção de hormônios associados ao crescimento e sobre a produção dos hormônios sexuais. CONCLUSÃO: Estes achados sugerem que as condições inadequadas de nutrição contribuem para o retardo maturacional. Ressalta-se assim, a importância de estratégias de intervenção que possam garantir melhores condições de vida, saúde e nutrição para o desenvolvimento adequado das potencialidades vitais.The objective of this study is to assess the influence of stunting on the developmental delay of helminth-infected children and adolescents. METHODS: The sample of this cross-sectional study consisted of 1,764 subjects of both sexes from the city of Jequié (Bahia, Brazil), aged 7 to 17 years, infected with helminths (either Schistosoma mansoni alone or associated with associated with geohelminths). All subjects underwent anthropometric and Tanner stage assessment, and stool testing. Data on the family's socioeconomic status and sanitary conditions of the household were also collected. The data was analyzed by multivariate logistic regression. RESULTS: The results of this study show a prevalence of stunting of 15.4 percent and an association between stunting and pubertal delay (0R=4.01; CI 95 percent 1.01-15.8). The negative impact of malnutrition on the production of both sexual and growth-related hormones may explain this association. CONCLUSION: These findings suggest that inadequate nutrition contributes to developmental delay. This shows the importance of intervention strategies that guarantee better living and health conditions and nutrition for proper development