78 research outputs found

    Kajian Filsafat Ilmu Terhadap Pertambangan Batubara Sebagai Upaya Meningkatkan Kesejahteraan Rakyat Indonesia

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    The major issue in this research is about the study on the general philosophy (ontology, epistemology and axiology) towards the use of natural resource of coal mining as an effort to improve the Indonesian people welfare. This is a normative research in which the research approach used the approach of philosophy of laws examining the legal values embedded in the law and regulation related to the use of natural resource of coal mining in Indonesia. the result of the research showed that first, in the study of ontology, coal mining has contributed to the national economy that is supposed to be run in harmony with the Article 33 sentence (3) and (4) of Constitution 1945. Reflection now is the governance of state is more dominant in its use; thus, it needs a new balance in the form of national management policy. Second, in the study of epistemology, there is a need to use the principle of sustainable development in the coal mining with people economic system and even distribution; and third, in axiology, there is a need of the direct and indirect use in improving the welfare of Indonesian people

    Peran Orientasi Kewirausahaan Dan Orientasi Pasar Untuk Meningkatkan Kualitas Layanan Dan Kinerja Industri Hotel

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    This study aims to examine the relationship between entrepreneurial orientation (EO) and market orientation (MO) services quality (SQ), and its impact on organizational performance. Design / methodology / approach: The sampling plan is 273 managers of 273 hotels in East Kalimantan, the study is to bridge the gap and show the importance of entrepreneurial orientation (EO) and market orientation (MO) on service quality (SQ) and organizational performance (OP) in the service organization also provides theoretical contributions to the development of entrepreneurial orientation (EO) and market orientation (MO) in relation to service quality (SQ) and organizational performance (OP). The results showed that 1) EO effect on MO, SQ and PERF, 2) MO not significant effect on PERF and MO significant impact on the SQ, 3) SQ significant effect on PERF. The findings of this study to significantly improve knowledge of the impact of entrepreneurial orientation (EO) and market orientation (MO) on service quality and organizational performance

    Pemetaan Distribusi Densitas Larva Aedes Aegypti di Kelurahan Tamalanrea Indah Kecamatan Tamalanrea Kota Makassar

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    Kelurahan Tamalanrea Indah adalah salah satu daerah endemis DBD di Kecamatan Tamalanrea. Tahun 2009 dilaporkan 18 kasus DBD dengan Angka Bebas Jentik 78%, tahun 2010 dilaporkan 12 kasus dengan ABJ 61%, dan tahun 2011 dilaporkan 3 kasus dengan ABJ 66% dan kematian 1 orang. Penelitian ini bertujuan memperoleh gambaran pemetaan distribusi densitas larva Aedes aegypti dan gambaran upaya PSN melalui kegiatan abatesasi dan 3M. Jenis penelitian adalah metode observasional dengan pendekatan deskriptif. Populasi dan sampel adalah seluruh rumah di Kelurahan Tamalanrea Indah dan sampel 114 rumah, dengan metode stratified random sampling. Hasil penelitian diperoleh pemetaan pelaksanaan tindakan 3M yang memenuhi syarat, yaitu 52 (45,6%) dengan keberadaan larva negatif dan tidak memenuhi syarat, yaitu 62 (54,4%) dengan positif larva 40 (64,5%). Pada pemetaan kegiatan abatisasi yang memenuhi syarat, yaitu 39 (37,5%) dengan keberadaan larva negatif dan yang tidak memenuhi syarat 65 (62,5%) dengan positif larva 40 (61,5%) dan yang paling berperan dalam tindakan 3M adalah ibu rumah tangga sebesar 82 (71,9%). Densitas larva Aedes aegypti tergolong kepadatan sedang dengan density figure 5. Hal ini masih menunjukkan besarnya risiko penularan penyakit DBD

    Update 2013: the Role of Probiotic in Non-alcoholic Fatty Liver Disease, an Evidence Based Approach

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    During the last two decades, non-alcoholic fatty liver disease (NAFLD) has been a topic in many discussions. The major risk factors for NAFLD is metabolic syndrome, which include obesity, insulin resistance andhypertension. Beside insulin resistance, oxidative stress has been linked with the disease. There is accumulating evidence that intestinal bacterial overgrowth plays an important role in NAFLD pathogenesis. Intestinal bacteria influence the progression of NAFLD through endogenous ethanol production and cytokine that would eventually induce hepatic oxidative stress. Probiotic intervene pathogenic intestinal flora so it is a potential treatment for NAFLD. Many animal studies documented the beneficial effect of probiotic in NAFLD. Probiotic reduce hepatic inflammation, reduce hepatic steatosis and improve insulin resistance. There is still limited human studies upon this topic. However, preliminary result showed potential role of probiotic in NAFLD treatment. Probiotic is safe, cheap and widely available therefore it is a promising new approach for NAFLD therapy. Upcoming study would hopefully provide firm foundation regarding the use of probiotic for NAFLD on human

    Idiopathic Portal Hypertension: a Rare Cause of Recurrent Hematemesis Melena

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    Idiopathic portal hypertension (IPH) known as non-cirrhotic portal fibrosis (NCPF) is a constellation of liver disorders, in which liver cirrhosis is not present and the main clinical and pathological findings are encountered in the portal venous system. Patients usually come to hospital with esophageal varices and upper gastrointestinal bleeding; however, it is often misdiagnosed as liver cirrhosis. Its etiology is still unknown, but some evidences and epidemiological studies suggest that it is a multifactorial disease with genetic basis. The laboratory evaluation in IPH reveals only mild and subtle abnormalities predominantly related to hypersplenism. The major complications of IPH are esophageal varices and hypersplenism. Endoscopic sclerotherapy or band ligation, shunt surgery, and transjugular intrahepatic portosystemic shunt (TIPS) are modalities to treat the complications of IPH. The case report reported about diagnosis and treatment of a 20-year-old male with idiopathic portal hypertension

    Single Nucleotide Polymorphism Promoter -765g/C Gen Cox-2 sebagai Faktor Risiko Terjadinya Karsinoma Kolorektal

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    Karsinoma kolorektal (KKR) merupakan keganasan yang berasal dari transformasi neoplastik sel-sel epitel kolon dan rektum, menempati urutan ketiga terbanyak dari seluruh kanker di seluruh dunia.Berbagai Perubahan DNA dapat terjadi akibat paparan dengan lingkungan dan karsinogen. DNA yang gagal berpasangan menimbulkan instabilitas genetik, mutagenesis, dan kematian sel, disebut sebagai single nucleotide polymorphisms (SNPs). Polimorfisme adalah Perubahan atau mutasi pada gen yang tidak menimbulkan Perubahan struktur protein hanya mengakibatkan variasi fungsi protein, tidak bermanifestasi klinis, hanya bisa menentukan kerentanan terhadap penyakit. Jenis penelitian ini adalah deskriptif observasional pada gen COX-2 dengan metode PCRRFLP. Desain penelitian yang digunakan pada penelitian ini adalah case series, dilakukan di Laboratorium Klinik RSUP dr. Mohammad Hoesin Palembang selama 4 bulan, dari bulan Mei sampai dengan November 2012. Terdapat empat puluh (40) orang subjek penelitian yang merupakan penderita KKR, semuanya berasal dari seluruh etnis yang berdomisili di Sumatera Selatan dan bersedia ikut serta dalam penelitian. Penderita karsinoma kolorektal yang berjenis kelamin laki-laki (52,5%) lebih banyak daripada wanita (47,5%), lokasi karsinoma pada daerah kolon (25%) lebih banyak daripada daerah rektum (75%), dan penderita dengan adenokarsinoma (77,5%) merupakan jenis terbanyak diikuti musinus adenokarsinoma (17.5%) dan adenoskuamous karsinoma (5%). Distribusi genotip CC (mutan) sebanyak 10%, genotip GC (heterozygot) sebanyak 10%, dan, genotif GG (normal) sebanyak 80%. Sedangkan Distribusi alel C (mutan) sebanyak 16% dan alel G (normal) sebanyak 84%. Penelitian ini terbatas pada identifikasi polimorfisme gen COX2 pada kasus KKR, tidak melihat hubungan atau pengaruh polimorfisme gen COX-2 terhadap kejadian KKR. Perlu dilakukan wawancara lebih lanjut terhadap pasien mengenai suku, etnis, riwayat keluarga. Perlu dilakukan penelitian lebih lanjut untuk mengetahui hubungan polimorfisme promoter -765G/C Gen COX-2 dengan kejadian karsinoma kolorektal

    Penyekat Beta sebagai Terapi Anti-Remodeling pada Gagal Jantung

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    Penyakit kardiovaskular merupakan penyebab kematian utama dan setiap tahunnya terjadi 50 juta kematian di seluruh dunia. Gagal jantung tercatat sebagai salah satu penyakit kardiovaskularyang sering terjadi. Pada gagal jantung, terjadi remodelling sel yang mengakibatkan penurunanfungsi pompa jantung. Seiring dengan kemajuan penelitian di bidang kardiovaskuler, penyekatbeta telah diteliti penggunaannya sebagai terapi anti-remodelling. Sampai sekarang, penelitian danstudi terkait hal tersebut masih terus dilakukan. Tujuan penulisan makalah ini untuk menjelaskanperan penyekat beta sebagai terapi anti-remodelling pada gagal jantung. Pencarian terstrukturmelalui PubMed mendapatkan 93 artikel, setelah disesuaikan dengan kriteria eksklusi dan inklusididapatkan 25 artikel. Setelah membaca artikel secara lengkap, didapatkan 11 artikel yang sesuai.Kemudian artikel tersebut ditelaah dalam menentukan validitas, relevansi, dan aplikabilitas. Dari 11artikel yang ditelaah kritis, didapatkan bahwa beta-blocker dapat berperan sebagai anti-remodellingmelalui peningkatan fungsi jantung sebagaimana terlihat pada kenaikan ejection fraction (EF),penurunan left ventricular end systolic volume (LVESV) dan left ventricular end diastolic volume(LVEDV) pada pasien gagal jantung

    Analisa Keandalan Jaringan Local Area Network (LAN) PT. Chevron Pacific Indonesia- Duri Menggunakan Distribusi Weibull

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    Reliability is the ability of a system or component performs all the functions needed specific time period. Reliability Networking Local Area Network (LAN) is determined from the failure rate. This journal discusses Reliability Networking LAN analysis based on the value of the MTTF. This failure occurs on a physical disorder that includes transmission side include electric, ups, switches, transmission (fiber optic), converters, patch cords, connectors and others. The method that used in analyzing reliability is Distribusi Weibull. The calculation method of the Weibull distribution parameters using LSM. From the calculation, the shape parameter value is 1.9664 and scale parameter value is 3.4039. MTTF value of 0.9936 months, the uptime value of 11.0664 month, reliability value of 0.9222

    Liver Transplant in Hepatocellular Carcinoma: Indication and Prognostic Factors

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    Hepatocellular carcinoma (HCC) is the most common type of liver cancer. There are several treatment modalities according to Barcelona treatment algorithm. Liver transplant is one of the curative option treatments, with its indication and prognostic factors. Carefully selected patients for liver transplant in HCC case will result in the same or slightly inferior survival rate compare with liver transplant in non-Malignancy case
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