Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study in Pregnant Women with Extragenital Pathology

The aim of this research was to study the parameters of fetal ultrasound imaging and Doppler ultrasound study in pregnant women with extragenital diseases (EGDs) during the treatment regimes with and without hyperbaric oxygen therapy (HBOT). Materials and Methods: A total of 235 pregnant women were examined prospectively at 5 to 40 weeks of gestation. The main group included 191 women with EGDs (anemia, arterial hypertension, chronic pyelonephritis); the control group included 44 women with physiological pregnancy without EGDs. Evaluation of treatment efficacy was based on data from clinical and laboratory findings before treatment and after its completion. The following hardware methods of research were performed: ultrasonography, fetometry, dopplerometric study of fetoplacental complex. Results: Based on data obtained from this study, the following findings were made: - In the early stages of gestation, there were no disturbances in fetoplacental blood circulation. - Starting the 19th week of pregnancy, there is a significant increase in the uterine artery resistive index in pregnant women with arterial hypertension. - In women with a high perinatal risk on the background of the studied EGDs, the third trimester of pregnancy, despite the ongoing conventional treatment, is characterized by persistent impairment in fetoplacental blood circulation. - The inclusion of HBOT in complex therapy in the early stages of pregnancy in women with a high perinatal risk allows leveling out the inevitable disturbances in fetoplacental blood circulation on the background of the studied EGDs

Non-destructive Assessment of Relief Marking Parameters of Heat Shrinkable Installation Parts for Aviation Technology

The article explains a new method of relief marking of heat-shrinkable tubing and sleeves made of polymer materials with “shape memory effect.” Method of instrument evaluation of relief marking stereometry of installation parts for aviation equipment, made of polyvinyl chloride, polyethyleneterephthalate and polystyrene was developed and the results were explained. Parameters of pin-point relief marking and compliance of point forms to the Braille font standard were determined with the use of the non-destructive method based on the color of interference pattern with precision of 0.02 mm

Non-destructive Assessment of Relief Marking Parameters of Heat Shrinkable Installation Parts for Aviation Technology

The article explains a new method of relief marking of heat-shrinkable tubing and sleeves made of polymer materials with “shape memory effect.” Method of instrument evaluation of relief marking stereometry of installation parts for aviation equipment, made of polyvinyl chloride, polyethyleneterephthalate and polystyrene was developed and the results were explained. Parameters of pin-point relief marking and compliance of point forms to the Braille font standard were determined with the use of the non-destructive method based on the color of interference pattern with precision of 0.02 mm

Perinatal Outcomes in Women with Extragenital Diseases

An increase in the incidence of extragenital diseases (EGDs) in the population against the background of the rise in the birth rate actualizes the problems of pregnancy management in women with EGD. Pregnancy-induced physiological changes in the body lead to a worsening of the course of diseases that were at the stage of unsustainable compensation before pregnancy. The purpose of our study was to determine the effectiveness of hyperbaric oxygenation (HBO) in the prevention of obstetric/perinatal complications in pregnant women with EGDs and neonatal morbidity. The inclusion of HBO in a complex of therapeutic and prophylactic measures in pregnant women with high perinatal risk contributed to a significant reduction in premature birth and a statistically significant improvement in neonatal morbidity parameters

Results of Fetal Ultrasound Imaging and Doppler Ultrasound Study Depending on the Factors of Perinatal Risk in Preterm Birth

Premature birth (PB) is associated with placental insufficiency, which is confirmed in the morphological study of the placenta. Ultrasonic markers of placental abnormalities, often preceding PB, have been identified: changes in placental structure, premature ripening of the placenta, oligohydramnios, and fetal-placental circulation

Proteasome functioning in breast cancer: connection with clinical-pathological factors.

Breast cancer is one of four oncology diseases that are most widespread in the world. Moreover, breast cancer is one of leading causes of cancer-related deaths in female population within economically developed regions of the world. So far, detection of new mechanisms of breast cancer development is very important for discovery of novel areas in which therapy approaches may be elaborated. The objective of the present study is to investigate involvement of proteasomes, which cleave up to 90% of cellular proteins and regulate numerous cellular processes, in mechanisms of breast cancer development. Proteasome characteristics in 106 patient breast carcinomas and adjacent tissues, as well as relationships of detected proteasome parameters with clinical-pathological factors, were investigated. Proteasome chymotrypsin-like activity was evaluated by hydrolysis of fluorogenic peptide Suc-LLVY-AMC. The expression of proteasome subunits was studied by Western-blotting and immunohistochemistry. The wide range of chymotrypsin-like activity in tumors was detected. Activity in tumors was higher if compared to adjacent tissues in 76 from 106 patients. Multiple analysis of generalized linear models discovered that in estrogen α-receptor absence, tumor growth was connected with the enhanced expression of proteasome immune subunit LMP2 and proteasome activator PA700 in tumor (at 95% confidence interval). Besides, by this analysis we detected some phenomena in adjacent tissue, which are important for tumor growth and progression of lymph node metastasis in estrogen α-receptor absence. These phenomena are related to the enhanced expression of activator PA700 and immune subunit LMP7. Thus, breast cancer development is connected with functioning of immune proteasome forms and activator PA700 in patients without estrogen α-receptors in tumor cells. These results could indicate a field for search of new therapy approaches for this category of patients, which has the worst prognosis of health recovery

Dependence of ChTL activity difference in tumor and adjacent tissue on ChTL activity in breast samples.

<p>(A) F(1) = 519.763; <i>p</i><0.001. (B) F(1) = 0.947; <i>p</i> = 0.333. Calculated at 95% confidence.</p

Regulatory network between ERα and proteasome immune subunit LMP2 in breast cancer.

<p>MIR, microRNA; SOX4, PU.1 (SPI 1), MYC, transcription factors. Created within open informatics site MirOB, (<a href="http://mirob.interactome.ru/pathway_navigator" target="_blank">http://mirob.interactome.ru/pathway_navigator</a>, 2012−2013).</p

Statistical indicators for revealed dependence of the proteasome parameters in breast samples on simultaneous effect of clinical-pathological factors.^1.

1<p>Multiple GLM (generalized linear models) analysis was applied;</p>2<p>F (DF), F-test value for indicated pair of interacting signs (Degrees of Freedom);</p>3<p><i>p</i>, statistical significance of observed effects.</p><p>Statistical indicators for revealed dependence of the proteasome parameters in breast samples on simultaneous effect of clinical-pathological factors.^1.</p

Expression of immune subunits LMP2 and LMP7 in cytokeratin 18 containing cells of IDC sample.

<p>(Panels A) Mouse mAbs to cytokeratin 18, rabbit pAbs to LMP2. (Panels B) Mouse mAbs to cytokeratin 18, rabbit pAbs to LMP7. IDC, invasive ductal carcinoma. Scale bar, 100 µm.</p