Erysipelas. Clinical aspects of evolution dependig on gender

Catedra Boli Infecţioase, tropicale şi parazitologie medicală USMF „Nicolae Testemiţanu”70 patients aged 23—80 years, with erysipelas were included in the study. For the first time in Moldova the evolutional peculiarities of this disease in women and men have been studied. This has allowed determining some characteristics of erysipelas depending on sex. The purpose of the study was to compare the evolution of erysipelas in women and men. The results obtained revealed common features and differences of erysipelas in women and men. În studiu au fost incluşi 70 bolnavi de erizipel cu vîrsta cuprisa între 23 şi 80 ani. În premieră în Republica Moldova pe larg au fost studiate particularităţile bolii la femei şi bărbaţi. Aceasta a permis stabilirea unor particularităţi ale erizipelului în dependenţă de gen. Rezultatele obţinute au pus în evidenţa trăsăturile comune şi diferenţele evoluţiei erizipelului la femei şi bărbaţi

Mucocutaneous manifestations in patients with HIV/AIDS infection

Generalităţi. Procesul epidemic al infecţiei HIV/SIDA, în Republica Moldova (RM), se află în continuă ascensiune. Astfel, conform datelor statistice, la 01.01.2015, în RM, au fost înregistrate 10 213 cazuri de HIV infectaţi, dintre care diagnosticaţi cu SIDA – 3130 şi deja decedaţi – 2892 de persoane. Ţinând cont de faptul că manifestările cutaneo-mucoase sunt frecvent întâlnite la persoanele HIV infectate, ne-am propus ca scop evaluarea frecvenţei şi particularităţilor clinico-evolutive ale leziunilor dermatologice la pacienţii cu infecţie HIV/SIDA. Material şi metode. Studiul retrospectiv a cuprins 2244 de fişe ale pacienţilor cu diagnosticul HIV/SIDA, internaţi în Spitalul Dermatologie şi Maladii Comunicabile pentru perioada 2011-2014. De asemenea, au fost înregistrate o serie de cazuri clinice mai relevante. Rezultate. Pe parcursul perioadei de referinţă, au fost înregistraţi 1886 de pacienţi cu manifestări cutaneo-mucoase, dintre care valoarea CD4+ sub 200 cel/mmc a fost inregistrată la 881 de pacienţi. Afectarea solitară a mucoaselor a fost estimată la 1383 de pacienţi, afectarea solitară a pielii la 92 de pacienţi şi afectarea combinată cutaneo-mucoasă – la 411 pacienţi. Atingerea mucoasei cavităţii bucale a fost raportată în 96% din cazuri, cu prevalenţa incontestabilă a infecţiei provocate de C. albicans, exprimată prin candidoză orofaringiană sau esofagiană. Evaluarea ponderii atingerilor cutanate la pacienţii HIV infectaţi a evidenţiat prezenţa manifestărilor cutanate infecţioase în 52% cazuri, al manifestărilor non-infecţioase - în 45% cazuri (dintre care mai mult de 2/3 au fost cu dermatoze alergice) şi doar la 3% din cazuri – manifestări neoplazice. Formele clinice ale atingerilor cutaneo-mucoase şi evoluţia lor au corelat cu valoarea numerică a celulelor CD4. Concluzii. Manifestările cutaneo-mucoase se întâlnesc la persoanele HIV-infectate în 84% din cazuri. Mai frecvent, se afectează mucoasa cavităţii bucale. Severitatea şi forma clinică a atingerilor cutaneo-mucoase corelează cu valoarea limfocitelor CD4. În majoritatea cazurilor, leziunile cutaneo-mucoase la pacienţii HIV-infectaţi, apar în urma imunităţii scăzute şi pot fi considerate ca semne revelatoare ale imunosupresiei legate de HIV, fapt care permite identificarea precoce a acestei infecţii.Overview. Epidemic evolution of HIV/AIDS in the Republic of Moldova is in a permanent progression. Thus, in accordance with statistic data on 01.01.2015 in the Republic of Moldova 10213 cases of HIV/AIDS were registered, among those 3130 people were identified with AIDS and 2892 have already died. It is well known that mucocutaneous manifestations are not rare in patients with HIV/AIDS this is why authors’ aim was to evaluate frequency and clinico-evolutive peculiarities of skin lesions in patients with HIV/AIDS. Materials and methods. A retrospective research was done, which included 2244 medical files of patients with HIV/AIDS, who have been treated at the Hospital of Dermatology and Communicable Diseases during 2011-2014. A number of relevant clinical cases were described as well. Results. 1886 patients with HIV/AIDS, who have shown mucocutaneous involvement, have been registered during present research, in 881 of them CD4+ count was less than 200cells/mmc. Involvement of mucous membranes was established only in 1383 cases, of the skin only in 92 cases and both mucocutaneous manifestations in 411 patients. Mucous membrane affection was reported in 96% of cases with incontestable prevalence of C. albicans infection manifested by oropharyngeal or esophageal candidiasis. Evaluation of cutaneous involvement in patients with HIV has shown as follows: presence of skin infections in 52% of cases, non-infectious dermatoses in 45% of cases (2/3 of which were allergic skin disorders) and skin tumors in 3% of patients only. Clinical forms of skin diseases and their evolution was in strong correlation with CD4+ cells count. Conclusions. Mucocutaneous manifestations affect patients with HIV/AIDS in 84% of cases. The most frequent target is oral cavity. Severity and clinical forms of mucocutaneous involvement have a strong correlation with CD4+ cell count. In majority of cases, mucocutaneous lesions in patients with HIV occur because of decreased immune response and might be considered relevant signs of immunosupression induced by HIV, as well as comprehensive tool for HIV/AIDS early detection

Клинические особенности энтеровирусной инфекции

Summary: A retrospective analysis of the medical histories of 76 patients with enteroviral infection. They were recorded in 40,0% of children and 60% of adults respectively. Among adult patients, the prevalence was revealed in those aged 19-45 years (43%). In both children and adults, enteroviral infection proceeded in moderate and severe form (83% and 17% respectively). The diagnosis of disease was confirmed clinical, epidemiological, and laboratory.Резюме: Проведён ретроспективный анализ истории болезни 76-х больных с энтеровирусной инфекцией. Из них дети составили 40,0%, взрослые – 60,0%. Среди взрослых преобладали пациенты в возрасте 19-45 лет (43,0%). Как у детей, так и у взрослых энтеровирусная инфекция протекала в средней и тяжёлой форме (83% и 17% соответственно). Диагноз заболевания был подтвержден клиническими, эпидемиологическими и лабораторными исследованиями

Impact of late presentation in the treatment effectiveness for HIV-infected patients in the Republic of Moldova

13th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, 08-10 November 2017, Bucharest, Romania, “Toma Ciorbă” Clinical Hospital for Infectious Diseases, Chișinău, Republic of Moldova, Hospital of Dermatovenerology and Communicable Diseases, Chișinău, Republic of Moldova, National Public Health Center, Republic of Moldov

Clinico-evolutive aspects of enteroviral infection

Catedra Boli infecţioase FECMF, Catedra Boli infecţioase tropicale şi parazitologice medicală, USMF « Nicolae Testemiţanu »Enteroviral infections incidence are particularly high among the general population are quite contagious and easily spread in communities of children, sometimes triggering epidemics. The study refers to a group of 76 patients, admitted to the Infectious Diseases Hospital "Toma Ciorbă" in 2012 with the diagnosis of enteroviral infection confirmed by clinical, epidemiological and laboratory data. Incidenţa infecţiei enterovirale este deosebit de mare în rândul populaţiei generale, sunt destul de contagioase şi se răspîndesc uşor în colectivităţi de copii, declaşînd uneori epidemii. Studiul se referă la un lot de 76 bolnavi, internaţi în Spitalul Clinic de Boli Infecţioase”Toma Ciorbă” în anul 2012 cu diagnosticul de infecţie eterovirală confirmat prin date clinice, epidemiologice şi de laborator.