Properties of two biological glasses used as metallic prosthesis coatings and after an implantation in body

présentation faite par Y. Barbottea

Distribution and outcomes of a phenotype-based approach to guide COPD management: Results from the CHAIN cohort

Rationale: The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. Objective: We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. Methods: We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Results: Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p<0.05). The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05 compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05) with no differences in one-year mortality. Most of NE (93%) and half of exacerbators were stable after one year. Conclusions: There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use

Etude de la pénétration de l'arsenic des eaux de la Bourboule en fonction de leur mode d'administration

L'absence de principe actif défini rend délicate l'étude de la biodisponibilité de la plupart des eaux minérales ; grâce à leur concentration en Arsenic, les eaux thermales de La Bourboule se prêtent à une telle étude. Les auteurs tentent d'étudier la disponibilité comparée de l'Arsenic en fonction des 3 principaux modes d'administration utilisés dans la station : aérosol, inhalation, boisson. Les concentrations sanguines et tissulaires de l'Arsenic sont appréciées par activation neutronique. Les résultats obtenus montrent une bonne disponibilité de l'Arsenic lors de l'administration orale. Les examens des différents tissus des voies respiratoires mettent en évidence la pénétration de l'arsenic jusqu'aux bronches. Malgré la sensibilité de la méthode de mesure, la diffusion de l'arsenic dans le sang à partir du tissu pulmonaire n'est pas démontrée. Les auteurs concluent sur la nécessité de pousser plus avant leurs investigations par l'étude de la distribution de l'Arsenic dans le contexte d'une cure