1 research outputs found
Universal One-Pot and Scalable Synthesis of SERS Encoded Nanoparticles
Encoded
particles are one of the most powerful approaches for multiplex
high-throughput screening. Surface-enhanced Raman scattering (SERS)
based codification can, in principle, avoid many of the intrinsic
limitations due to conventional alternatives, as it decreases the
reading time and particle size while allowing for almost unlimited
codification. Unfortunately, methods for the synthetic preparation
of these particles are tedious; often subjected to limited reproducibility
(associated with large fluctuations in the size distributions of the
polymers employed in the standard protocols); and to date, limited
to a small amount of molecules. Herein, we report a universal, one-pot,
inexpensive, and scalable synthetic protocol for the fabrication of
SERS-encoded nanoparticles. This synthetic strategy is highly reproducible,
independent of the chemical nature and size of the Raman code used
(31 different codes were tested) and scalable in the liter range without
affecting the final properties of the encoded structures. Furthermore,
the SERS efficiency of the fabricated encoded nanoparticles is superior
to that of the materials produced by conventional methods, while showing
a remarkable reproducibility from batch to batch. This encoding strategy
can easily be applied to nanoparticles of different materials and
shapes