Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates-1

<p><b>Copyright information:</b></p><p>Taken from "Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates"</p><p>http://www.biomedcentral.com/1471-2148/7/187</p><p>BMC Evolutionary Biology 2007;7():187-187.</p><p>Published online 4 Oct 2007</p><p>PMCID:PMC2082429.</p><p></p>yan. and are represented as grey blocks. The chromosome number in the corresponding genome is provided. Dashed lines correspond to regions of break of synteny. Abbreviations: , Homo sapiens; , Pan troglodytes; , Macaca mulatta; , Mus musculus; , Rattus norvegicus; , Gallus gallus. . Since for chimp and macaque no mRNA sequences are available, the human and were used as templates for gene predictions. In chimp, the intron putatively gained by is composed of eight repeats. In the genomic regions corresponding to chimp , there are four additional Zn-Fingers, which are reported in black because there is no evidence for their transcription. The dashed lines represent regions of gaps in the genome assembly. In rodents, the last intron is longer and not in scale; the corresponding length is reported in brackets. . The grey lines represent the genomic regions of segmental duplication. The corresponding chromosome number, chromosomal coordinates and direction of transcription are given. For , the splicing variants present in the database are shown. For , both the database transcripts and the isoforms detected in this study are reported together with an in-silico gene prediction obtained by using the PRDM9 long isoform as template

Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates-0

<p><b>Copyright information:</b></p><p>Taken from "Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates"</p><p>http://www.biomedcentral.com/1471-2148/7/187</p><p>BMC Evolutionary Biology 2007;7():187-187.</p><p>Published online 4 Oct 2007</p><p>PMCID:PMC2082429.</p><p></p>are shown in grey. On main bifurcations, the corresponding posterior probability from Bayesian inference is reported (see Methods). Different colours associated to tree branches correspond to the main subfamilies. For each subfamily, the gene structure of human PRDM ortholog is depicted. The scale refers to exons only. The tree image was produced using iTOL [44]. . PRDM genes are ordered by increasing evolutionary divergence, calculated as cumulative branch lengths from the tip to the root of the phylogenetic tree. The expression data were measured as the mean values of different assays for each gene (see Methods). The upper limit of the 2values was set to 10. For original values see Additional file