The contextual awareness, response and evaluation (CARE) diabetes project: study design for a quantitative survey of diabetes prevalence and non-communicable disease risk in Ga Mashie, Accra, Ghana

Diabetes is estimated to affect between 3.3% and 8.3% of adults in Ghana, and prevalence is expected to rise. The lack of cost-effective diabetes prevention programmes designed specifically for the Ghanaian population warrants urgent attention. The Contextual Awareness, Response and Evaluation (CARE): Diabetes Project in Ghana is a mixed methods study that aims to understand diabetes in the Ga Mashie area of Accra, identify opportunities for community-based intervention and inform future diabetes prevention and control strategies. This paper presents the study design for the quantitative survey within the CARE project. This survey will take place in the densely populated Ga Mashie area of Accra, Ghana. A household survey will be conducted using simple random sampling to select households from 80 enumeration areas identified in the 2021 Ghana Population and Housing Census. Trained enumerators will interview and collect data from permanent residents aged ≥ 25 years. Pregnant women and those who have given birth in the last six months will be excluded. Data analysis will use a combination of descriptive and inferential statistics, and all analyses will account for the cluster sampling design. Analyses will describe the prevalence of diabetes, other morbidities, and associated risk factors and identify the relationship between diabetes and physical, social, and behavioural parameters. This survey will generate evidence on drivers and consequences of diabetes and facilitate efforts to prevent and control diabetes and other NCDs in urban Ghana, with relevance for other low-income communities

Perceptions of a mobile phone-based approach to promote medication adherence: A cross-sectional application of the technology acceptance model

Background: In several African and Asian countries, callers to mobile phones sometimes hear a song or message in place of the typical ringing sound. This application, called caller tunes, may offer a unique opportunity to promote medication adherence that is yet to be explored. Objectives: Assess the application of the technology acceptance model to a potential caller tunes approach designed to enhance medication adherence, with a specific focus on the interrelationships of perceived ease of use, perceived usefulness, cost, and intention. Methods: Data from a cross-sectional sample of 996 adult mobile phone users in Ghana, approximately half of whom were current caller tunes users, was examined using exploratory factor analysis for scale evaluation and structural equation modeling to assess associations among perceived ease of use, perceived usefulness, and cost on intention to use mobile phone caller tunes to promote medication adherence. Results: Consistent with the technology acceptance model, intention to use the caller tunes as a means of enhancing medication adherence was higher among those who viewed the application positively in terms of ease of use and usefulness. Among those who were already caller tunes users, availability as a free download was also associated with more positive intentions. Conclusion: The present study provides preliminary evidence in support of caller tunes as a novel strategy to promote medication adherence. Future studies interested in using this approach would be advised to consider factors such as participants\u27 current use of caller tunes, age, availability as a free download, and perceptions of ease of use and perceived usefulness of the approach as potential moderators of study outcomes

Ethnomedicinal Survey of Plants Used for the Management of Hypertension Sold in the Makola Market, Accra, Ghana

Hypertension is a highly prevalent public health problem among Africans, including Ghanaians, and it is a major risk factor for cardiovascular diseases such as congestive heart failure, kidney disease, and coronary artery disease. Hypertension occurs at a rate of 19% to 48% across Ghana; and because about 70% of the patients are believed to be using herbs to manage this condition, it is important to know the kind of plants that are used in the management of this condition. The aim of this study was therefore to conduct an ethnomedicinal survey to document medicinal plant species which are sold on the open Ghanaian market; and are traditionally used in the treatment of hypertension. Validated questionnaires were administered to sellers of dried or semi-processed herbs at the Makola market, in the Accra Metropolitan Area. The survey identified the plant materials and the way and manner; by which these plant materials are prepared and administered. A total of 13 plant species belonging to 13 plant families were identified. The following medicinal plants were found to be commonly sold for the treatment of hypertension: Bambusa vulgaris (Graminaeae), Bridellia ferruginea (Euphorbiaceae), Carica papaya (Caricaceae), Mangifera indica (Anacardiaceae), Moringa oleifera (Moringaceae), Nauclea latifolia (Rubiaceae), Ocimum gratissimum (Lamiaceae), Parkia biglobosa (Leguminosae), Persea americana (Lauraceae), Proporis africana (Leguminosae – Mimosoideae), Pseudocedrela kotschyii (Maliaceae), Theobroma cacao (Sterculiaceae) and Vitellaria paradoxa (Sapotaceae). Leaves and roots of these plants predominated other plant parts. Most of these herbs were prepared as aqueous decoctions before administration. In conclusion, there are many medicinal plant species used to treat several conditions, including hypertension, within the Ghanaian community. This study therefore underscores the need to preserve, document and scientifically investigate traditional herbs used for the treatment of various diseases of public health importance, and to optimize their use since they serve as alternative treatment

Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats

Abstract Background Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain. Methods Neuropathy was induced in rats by a continuous intraperitoneal administration of paclitaxel (2 mg/kg) for 5 days. Baseline latencies to thermal pain were recorded before the first injection of paclitaxel and during the 5 day induction period. Following the induction, the rats in designated treatment group were treated with the hydro-ethanolic extract (100, 300 and 1000 mg/kg, p.o) or pregabalin (10, 30 and 100 mg/kg) or vehicle (distilled water) and their responses to thermal hyperalgesia measured every 30 for a total period of 3 h. Results There was a significant difference between the baseline reaction latency and what was observed on the 5th day of the induction of neuropathy. Two days after the induction of neuropathy, the extract and pregabalin significantly and dose-dependently produced antinociceptive effect during the 3-h test period. Conclusion The hydro-ethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced neuropathy in rats