1 research outputs found
Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration
Hydrogels are promising
candidates for biomimetic scaffolds of
the extracellular matrix in tissue engineering applications. However,
their use in bone tissue engineering is limited due to their low mechanical
properties. In this study, we designed and synthesized multicomponent
peptide-based hydrogels composed of fluorenyl-9-methoxycarbonyl diphenylalanine
(FmocFF), which contributed to the rigidity and stability of the hydrogel,
and Fmoc-arginine (FmocR), which mediated high affinity to hydroxyapatite
(HAP) due to the arginine moiety. The new hydrogels composed of nanometric
fibril networks were decorated with HAP and demonstrated high mechanical
strength with a storage modulus of up to 29 kPa. In addition, the
hydrogels supported cell adhesion and in vitro cell viability. These
properties suggest using these multicomponent organic–inorganic
hydrogels as functional biomaterials for improved bone regeneration