Diffuse Large B-Cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous class of aggressive lymphoma and is considered as the most common subtype of non-Hodgkin lymphomas (NHL). Several genetic anomalies such as point mutations, numerical alterations, and, more rarely, translocations and gene amplifications play a role in the pathogenesis of this class of B-cell lymphoma and have been related to specific histological and immunophenotypic subtypes. On the other hand, the treatment protocol in DLBCL did not witness significant changes during the last two decades. The widespread adoption of rituximab as an important adjuvant to standard chemotherapy protocol in CD20+ cases was a notable exception, which provided significant improvement in disease-free survival and overall survival, with limited toxicity. However, no less than 20% of patients diagnosed with DLBCL exhibit relapse after the initial response to R-CHOP regimen, while more than 15% of the patients exhibit primary refractory disease. This is the reason why a review of all the morphological, clinical, and therapeutic particularities of DLBCL is required

Improvement of learning quality in manufacturing technology: a case study

The paper presents the initial part of a study designed to understand the place of the present generation of engineering students in the global picture of their working life. The education represents an inestimable good that accompanies peoples through their existence. Higher education is the place were teenagers with different profiles modelled by their families, studies; experiences and so on come to meet, in most cases, the final education platform before employment. In light of this the higher education has the major role of prepare the students with the knowledge and skills appropriate to the labour market. That means with the knowledge and skills they need and their future employers are looking for. It involves a huge effort, dedicated to the transfer of knowledge and skills with a success rate as high as possible. To achieve this the study programs and the teaching methods must embody both objectives: to be tailored for the students and to meet the employers needs. That places the higher education on the border of the two parties, its role in achieving the outlined objectives being major

Improvement of learning quality in manufacturing technology: a case study

The paper presents the initial part of a study designed to understand the place of the present generation of engineering students in the global picture of their working life. The education represents an inestimable good that accompanies peoples through their existence. Higher education is the place were teenagers with different profiles modelled by their families, studies; experiences and so on come to meet, in most cases, the final education platform before employment. In light of this the higher education has the major role of prepare the students with the knowledge and skills appropriate to the labour market. That means with the knowledge and skills they need and their future employers are looking for. It involves a huge effort, dedicated to the transfer of knowledge and skills with a success rate as high as possible. To achieve this the study programs and the teaching methods must embody both objectives: to be tailored for the students and to meet the employers needs. That places the higher education on the border of the two parties, its role in achieving the outlined objectives being major

Welded Construction Design of Transition Fittings from Metal Pipes to Plastic Pipes

Transition type fittings are components often used in facilities where fluids are transported that allow the passage from a high density polyethylene (HDPE) pipe to a steel pipe. In the presented studies, four types of transition fittings were analyzed in the first stage. The four types of transition fittings are distinguished by the shape of their welded steel construction. The performed analyses took into account testing the behavior upon exposure to fatigue, measuring the HDPE hardness and applying the finite element method (FEM). As a result of these studies it was demonstrated that the form of the welded steel construction has a very great influence on the operating behavior of the transition fitting. Thus, a new transition fitting with a welded steel construction was designed. In this new type of transition fitting, an approximately 50% increase in resistance to fatigue stress, an approximately 90% reduction in stress in the part material and a reduction in the hardness of the material in HDPE pipes was obtained. The studies allow not only an improvement of the characteristics for these types of parts, but also the optimization of other types of steel-plastic joints

Smart Cutting Tools Used in the Processing of Aluminum Alloys

The processing of aluminum alloys in optimal conditions is a problem that has not yet been fully resolved. The research carried out so far has proposed various intelligent tools, but which cannot be used in the presence of cooling-lubricating fluids. The objective of the research carried out in the paper was to design intelligent tools that would allow a control of the vibrations of the tool tip and to determine a better roughness of the processed surfaces. The designed intelligent tools can be used successfully in the processing of aluminum alloys, not being sensitive to coolants-lubricants. In the research, the processing by longitudinal turning of a semi-finished product with a diameter Ø = 55 mm of aluminum alloy A2024-T3510 was considered. Two constructive variants of smart tools were designed, realized, and used, and the obtained results were compared with those registered for the tools in the classic constructive variant. The analysis of vibrations that occur during the cutting process was performed using the following methods: Fast Fourier Transform (FFT); Short-Time Fourier-Transformation (STFT); the analysis of signal of vibrations. A vibration analysis was also performed by modeling using the Finite Element Method (FEM). In the last part of the research, an analysis of the roughness of the processed surfaces, was carried out and a series of diagrams were drawn regarding curved profiles; filtered profiles; Abbott–Firestone curve. Research has shown that the use of smart tools in the proposed construction variants is a solution that can be used in very good conditions for processing aluminum alloys, in the presence of cooling-lubrication fluids

Pressure gradient effect on spin-crossover materials: Experiment vs theory

International audienceWe studied the effect of non-hydrostatic pressure on the hysteretic spin crossover in coordination complexes. By introducing into an Ising-like model a double distribution of the interactions and gap energy, respectively, we were able to generate the major hysteresis loop and the first-order reversal curve (FORC) diagram for spin-crossover systems of 106 hysterons (like-spin domains). We show that, for high pressure gradients around the spin-crossover system, the thermal hysteresis loop takes an asymmetric shape, in good agreement with the experimental data on pressure effect recorded at low temperatures, below the solidification of the pressure transmitting medium. Interestingly, the FORC diagram method seems to be much more sensitive to local changes than the “bulk” parameters, which characterize the major hysteresis loop

MATERNAL AND FETAL COMPLICATIONS OCCURRING IN HEREDITARY THROMBOPHILIA

Objective. To identify qualitative and quantitative changes involving coagulation factors engaged in maternal and fetal complications, to determine the level of correlation between them, and to highlight the involvement of hereditary thrombophilia among pregnant women. Material and method. The article is based on 92 publications from 1995 to 2017, including a total of 49,127 thrombophilic patients, of whom 1272 were controls, with inclusion criteria as preeclampsia, intrauterine growth retardation, or early or late pregnancy loss. Results. 31 studies based on preeclampsia- demonstrate the involvement of G1691A factor V Leiden gene mutation, G20210A Prothrombin gene mutation and/or C677T and A1298C MTHFR gene mutation as the main factors in the development of this complication. 10 studies focuses on the intrauterine growth restriction place G20210A Factor V Leiden gene mutation, G20210A Prothrombin gene mutation, C677T and A1298C MTHFR gene mutation, protein C and protein S deficiency as the main factors involved. Another 32 studies cite the involvement of factor V Leiden mutation, Prothrombin mutation and MTHFR mutation in the development of early or late pregnancy losses. Conclusion. Based on 92 rigorously selected publications, we were able to demonstrate the relationship between medium/increased risk thrombophilia and pregnancy outcome, especially due to the presence of factor V Leiden gene mutation, Prothrombin gene mutation but also MTHFR gene mutation homozygous status

COMPLICAŢII MATERNE ŞI FETALE APĂRUTE ÎN TROMBOFILIA DE CAUZĂ EREDITARĂ

Obiectiv. Identificarea modificărilor calitative şi cantitative ale mutaţiile factorilor de coagulare implicate în complicaţii materne şi fetale, determinarea nivelului de corelaţie dintre acestea şi gradul de implicare al trombofiliei ereditare în rândul femeilor însărcinate. Material şi metodă. Articolul se bazează pe 92 de publicaţii din 1995 până în 2017, incluzând 49.127 de paciente cu trombofilie, dintre care 1.272 au fost martori, având drept criterii de includere în studiu prezenţa preeclampsiei, retardul de creştere intrauterină sau pierderea timpurie sau tardivă a sarcinii. Rezultate. 31 studii bazate pe preeclampsie demonstrează implicarea mutaţiei genei G1691A factor V Leiden, a mutaţiei genei G20210A a protrombinei şi a mutaţiei genei C677T şi A1298C MTHFR ca factori principali în dezvoltarea acestei complicaţii. 10 studii se concentrează asupra gradului de restricţie de creştere intrauterine, iar mutaţia genei G20210A a factorului V Leiden, mutaţia genei G20210A a protrombinei, mutaţia genei C677T şi A1298C MTHFR, deficitul de proteina C şi proteină S fiind principalii factori implicaţi. Alte 32 de studii citează implicarea mutaţiei factorului V Leiden, a mutaţiei protrombinei şi a mutaţiei MTHFR în dezvoltarea pierderilor de sarcină precoce sau tardive. Concluzii. Pe baza a 92 de publicaţii riguros selectate, am putut demonstra relaţia dintre trombofilia cu risc mediu/crescut şi rezultatul sarcinii, în special din cauza prezenţei mutaţiei genei factor V Leiden, a mutaţiei genei protrombinei, dar şi a statusului homozigot al mutaţiei genei MTHFR

Piezoresistive Effect in the [Fe(Htrz)2(trz)](BF4) Spin Crossover Complex

International audienceWe report on the effect of hydrostatic pressure on the electrical conductivity and dielectric permittivity of the [Fe(Htrz)2(trz)](BF4) (Htrz = 1H-1,2,4,- triazole) spin crossover complex. Variable-temperature and -pressure broad-band impedance spectrometry revealed a piezoresistive effect of more than 1 order of magnitude for pressures as low as 500 bar, associated with a large pressure-induced hysteresis of 1700 bar. The origin of the piezoresistive effect has been attributed to the pressure-induced spin state switching in the complex, and the associated P,T phase diagram was determined

Influence of 45oV-type with collective ring turbulence promoters parameters of thermal performance of flat plate heat collector

This study explores the enhancement of thermal performance by disrupting the laminar sublayer through the use of turbulence promoters on the surface of a heated plate. The focus is on investigating how changes in several geometrical parameters of a V-rib combined with a collective ring impact fluid flow and heat transfer properties within a flat plate solar heat collector. Computational methods validated turbulence models, and a range of Reynolds numbers (4000–20000) were employed to conduct a comprehensive CFD analysis, examining flow dynamics and heat transport properties. The study specifically examines the influence of various parameters, including the relative V combined ring ratio (WD/WVR) ranging from 3.0 to 6.0, the Ratio of pitch V and ring to height V and ring (PVR/HVR) from 45.33 to 78, and the relative V and ring height (HVR/Dh) from 0.0238 to 0.0368. High friction factor (f) values were observed at settings of WD/WVR, PVR/HVR, and HVR/Dh at 6.0, 45.33, and 0.0368, respectively. Of significance, the findings indicate that both the thermohydraulic performance (THP) and Nusselt number (Nu) peak when WD/WVR, PVR/HVR, and HVR/Dh are set at 5.0, 63.33, and 0.0325, respectively. This optimal configuration demonstrates the potential to maximize heat transfer and overall system efficiency