Biological therapy in the treatment of melanoma

Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways involved in cell proliferation (Raf/MAPK/ERK signaling pathway), or administration of oncolytic viruses. Biological therapy in melanoma has shown promise in laboratory and clinical studies, with more therapeutic targets to be revealed as new molecular and cellular mechanisms of the disease are discovered

Adolescent motherhood and its public health implications

Davila University of Medicine and Pharmacy Romania, Bucuresti The 6th International Medical Congress for Students and Young DoctorsAdolescent pregnancy and parenting are considered social and public health issues. For most of the adolescents, pregnancy and childbirth are neither planned nor wanted. Early motherhood increases the risks for both mothers and their babies. One goal of our study is to evaluate this risk

Biological therapy in the treatment of melanoma

Melanoma is one of the most aggressive tumors and its incidence is on the rise. The low rates of survival in metastatic melanoma has led to the development of new drugs for this type of patient, such as biological therapy which has shown remarkable results. This therapy is based on stimulation of the immune system to fight tumoral cells through: injection of cytokines with immunomodulatory properties (interleukin-2, alpha-interferon), vaccination with tumor antigens or immune cells that process tumor antigens, adoptive immunotherapy, inhibition of immune checkpoints (PD-1, CTLA-4), inhibition or stimulation of immune modulator molecules (OX-40, LAG-3), inhibition of signaling pathways involved in cell proliferation (Raf/MAPK/ERK signaling pathway), or administration of oncolytic viruses. Biological therapy in melanoma has shown promise in laboratory and clinical studies, with more therapeutic targets to be revealed as new molecular and cellular mechanisms of the disease are discovered

The vaccination issue – who is responsible? Retrospective study on 278 infants hospitalized in a pediatric clinical hospital in Bucharest

Carol Davila University of Medicine and Pharmacy, Bucuresti, Romania The 6th International Medical Congress for Students and Young DoctorsVaccines represent one of the most effective and cost-saving public health interventions. Still, this measure continues to be under-used all over the world. Immunization averts an estimated 2 to 3 million deaths every year from diphtheria, tetanus, pertussis (whooping cough), and measles. Although globally the proportion of children who receive recommended vaccines has remained steady for the past few years, we observed during our clinical practice that the vaccination rate in Romania might be lower than the needed vaccination rate. The objective of this study is to test this hypothesis and to highlight the causes of low vaccination rates in Romania