Oxidative stress status of control and experimental groups, reflected by catalase and thiobarbituric acid reactive substances.

<p>Values are expressed as mean ± SEM</p

Comparative <i>In Vivo</i> Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity

<div><p>A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.</p></div

Immunological and clotting parameters of Control and experimental groups.

<p>Values are expressed as mean ± SD.</p

Renal function parameters of control and experimental groups.

<p>Values are expressed as mean ± SEM.</p

EPR spectra of Wistar rat venous blood (c.f. Materials and Methods) measured at 100K; the <i>g</i> values are indicated by arrows.

<p>EPR spectra of Wistar rat venous blood (c.f. Materials and Methods) measured at 100K; the <i>g</i> values are indicated by arrows.</p

Iron histochemical analyses.

<p>Iron histochemical analyses.</p

Comparison of the iron deposits in liver, spleen and kidney in Control and experimental groups.

<p>The structures were scored for their intensities of iron deposition in the range of + (normal aspects of the analyzed structures) and ++++ (the most intensely stained areas). The absence of iron deposits was marked with–(negative).</p

Blood ion concentration of control and experimental groups (mean ± SEM).

<p>Blood ion concentration of control and experimental groups (mean ± SEM).</p

EPR data for blood collected after injection of animals (n = 6) with 200 μL HBOC candidate.

<p>Percentage changes relative to the control group are shown, for the concentrations of metHb (g~6), free radical (g~2) and transferrin (g~ 4.1) signals, respectively.</p

Transferrin, total proteins, and glucose in control and experimental groups.

<p>Values are expressed as mean ± SEM</p