LUNAR HEAT FLOW EXPERIMENT LONG TERM TEMPERATURE OBSERVATIONS ON THE LUNAR SURFACE AT APOLLO SITES 15 AND 17 by

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The University of Virginia Experimental and Theoretical High Energy Physics Closeout Report

The work covered in this report includes a joint project on using gauge-gravity duality to discover qualitatively new results on jet quenching in strongly-coupled QCD-like plasmas. Other topics addressed by the theoretical work include jet stopping and energy loss in weakly-coupled plasmas, perturbative QCD amplitudes, AdS/CMT, dynamical electroweak symmetry breaking with a heavy fourth generation, electroweak-scale #23;{nu}{sub R} model, vacuum topological structure and chiral dynamics in strongly coupled gauge theory. Effort committed to the CMS experiment is reported, particularly the management, maintenance, operation and upgrade of the CMS electromagnetic detector (ECAL). Activities in various physics analyses including Supersymmetry, Higgs, Top, and QCD analyses are reported. Physics projects covering wide areas of physics at the LHC are reported. CY2010 saw the accumulation of a data sample corresponding to approximately 36 pb{sup -1}; in CY 2011 the data sample swelled to more than 5 fb{sup -1}. The UVa CMS analysis efforts are focused on this large 2011 data sample in a suite of crucial measurements and searches. KTeV physics activities are reported. Efforts are reported pertaining to several experiments, including: HyperCP, CKM, MIPP, D�, NO#23;{nu}A, and Mu2e

cGMP Recombinant FIX for IV and Oral Hemophilia B Therapy

Three specific aims are proposed: Specific Aim # 1. Process engineer and scale-up the recovery and purification of transgenic recombinant human Factor IX. The University of Nebraska-Lincoln Biological Process Development Facility will complete process development and scale-up, and produce clinical grade materials for preclinical studies. The endpoint is a proposed final product specification to help facilitate transfer to current Good Manufacturing Practices compliant production of clinical grade material to support an Investigational New Drug filing with the United States Food and Drug Administration (FDA) leading to clinical trials. Specific Aim #2. Characterize and formulate transgenic recombinant human Factor IX for intravenous dosage, and evaluate in a hemophilia B dog model. These activities are directed toward characterization of the product important to assure the provision of safe and reproducibly effective hemostasis. The results of these investigations will help support an IND filing with the FDA. Specific Aim # 3. Develop an oral dosage form of transgenic recombinant human Factor IX, and evaluate in hemophilia B mice and dog models. Oral administration of coagulation therapy will obviate the invasiveness, discomfort, potential for opportunistic infection, and complications of storage and supplies that accompany intravenous administration. Oral dosage forms of Factor IX will thus greatly increase the proportion of the patient population that can be treated. There is also published evidence suggesting that oral administration may reduce the potential for complicating immune responses to replacement therapy, especially in patients with severe hemophilia

Business Process Automation and Managerial Accounting: An SAP Plug and Play Module

The primary aim of our project is to develop an Enterprise Resource Planning (ERP) platform that enables students at Pace to understand how different interdisciplinary areas in cross-unit and/or cross-enterprise decision making are related. ERP can help us do this since it allows a firm to automate and integrate its business processes, share common data and practices across the entire enterprise, and provide and access information in a real-time environment

Business Process Automation and Managerial Accounting: An SAP Plug and Play Module (FINAL REPORT)

The primary aim of our project is to develop an Enterprise Resource Planning (ERP) platform that enables students at Pace to understand how different interdisciplinary areas in cross-unit and/or cross-enterprise decision making are related. ERP can help us do this since it allows a firm to automate and integrate its business processes, share common data and practices across the entire enterprise, and provide and access information in a real-time environment