19 research outputs found
Effets de facteurs immunologiques sur la morphologie, l'ultrastructure et la cytodynamique de cellules endotheliales aortiques cultivees in vitro
SIGLECNRS-CDST / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
EPIDEMIOLOGIE DE LA RADIOCARCINOGENESE Dossier de candidature à l'habilitation à diriger des recherches
Etude et realisation d'un terminal de consultation et d'un serveur d'images medicales
Available from INIST (FR), Document Supply Service, under shelf-number : AR 15782 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEMinistere de la Recherche et de la Technologie (MRT), 75 - Paris (France)FRFranc
Base d'archivage d'images medicales et systemes de gestion associes Faisabilite de l'integration d'une base locale dans un systeme de= communication d'images
Available from INIST (FR), Document Supply Service, under shelf-number : AR 15820 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEMinistere de la Recherche et de la Technologie (MRT), 75 - Paris (France)FRFranc
Recherche et caracterisation d'oncogenes actives dans les tumeurs du col de l'uterus
SIGLEAvailable at INIST (FR), Document Supply Service, under shelf-number : AR 13711 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Chimiotherapie a haute dose et autogreffe de moelle chez l'enfant Paris, 7 fevrier 1994
Available at INIST (FR), Document Supply Service, under shelf-number : YM 6613 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc
Les ambiances sonores des espaces d'accueil du service de radiodiagnostic de l'Institut Gustave Roussy
Etude realisee dans le cadre du Programme Nouveaux CommanditairesSIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : RP 16277 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
SARS-CoV-2 et cancer en France : les internes d’oncologie en première ligne. Témoignage des internes d’oncologie de deux clusters français : le Grand-Est et l’Île-de-France
Inter-observer variability in target delineation increases during adaptive treatment of head-and-neck and lung cancer
Introduction: Inter-observer variability (IOV) in target volume delineation is a well-documented source of geometric uncertainty in radiotherapy. Such variability has not yet been explored in the context of adaptive re-delineation based on imaging data acquired during treatment. We compared IOV in the pre- and mid-treatment setting using expert primary gross tumour volume (GTV) and clinical target volume (CTV) delineations in locoregionally advanced head-and-neck squamous cell carcinoma (HNSCC) and (non-)small cell lung cancer [(N)SCLC]. Material and methods: Five and six observers participated in the HNSCC and (N)SCLC arm, respectively, and provided delineations for five cases each. Imaging data consisted of CT studies partly complemented by FDG-PET and was provided in two separate phases for pre- and mid-treatment. Global delineation compatibility was assessed with a volume overlap metric (the Generalised Conformity Index), while local extremes of IOV were identified through the standard deviation of surface distances from observer delineations to a median consensus delineation. Details of delineation procedures, in particular, GTV to CTV expansion and adaptation strategies, were collected through a questionnaire. Results: Volume overlap analysis revealed a worsening of IOV in all but one case per disease site, which failed to reach significance in this small sample (p-value range .063–.125). Changes in agreement were propagated from GTV to CTV delineations, but correlation could not be formally demonstrated. Surface distance based analysis identified longitudinal target extent as a pervasive source of disagreement for HNSCC. High variability in (N)SCLC was often associated with tumours abutting consolidated lung tissue or potentially invading the mediastinum. Adaptation practices were variable between observers with fewer than half stating that they consistently adapted pre-treatment delineations during treatment. Conclusion: IOV in target volume delineation increases during treatment, where a disparity in institutional adaptation practices adds to the conventional causes of IOV. Consensus guidelines are urgently needed