Le diabète: facteur de risque rare pour la gale croûteuse

a gale croûteuse généralisée est une affection rare et grave secondaire à une hyperinfestation par le Sarcoptes scabiei. Elle survient souvent chez des sujets immunodéprimés ou ayant un déficit neurologique. Nous rapportons l’observation d’une femme âgée de 76 ans qui consultait pour une éruption généralisée modérément prurigineuse évoluant depuis 3 mois. L’examen cutané montrait une érythrodermie croûteuse et squameuse associée à une hyperkératose palmo-plantaire. L’examen parasitologique montrait de multiples sarcoptes. Le bilan biologique à la recherche d’un facteur d’immunodépression révélait un diabète type 2. Le traitement consistait en un traitement concomitant par des agents kératolytiques et un scabecide local. Une guérison clinique était obtenue en fin de traitement. A travers cette observation nous attirons l’attention sur cette forme particulière de gale et incitons à la pratique systématique d’examens parasitologique cutanés devant toute érythrodermie sèche squameuse et croûteuse trainante même en l’absence de facteur d’immunodépression évident

Bathing suit ichthyosis caused by a TGM1 mutation in a Tunisian child

International audienceBackgroundBathing suit ichthyosis (BSI) is an uncommon phenotype classified as a minor variant of autosomal recessive congenital ichthyosis (ARCI). ObjectivesWe report a case of BSI in a 3-year-old Tunisian girl with a novel mutation of the transglutaminase 1 gene (TGM1). Case ReportThis infant had been born with a collodion membrane encasing her entire body. From the age of threemonths, brownish scaling was noted on the bathing suit area. Histology showed orthohyperkeratosis with acanthosis of the epidermis. The granular layer was normal, and the superficial dermis was mildly inflammatory, confirming a diagnosis of proliferating ichthyosis. Molecular analysis in the patient and her parents revealed the mutation I304F of TGM1. Treatment with emollients and keratolytics partially improved the patient's skin condition. ConclusionsBathing suit ichthyosis is an uncommon phenotype unique in its topography, which involves the trunk but spares the face and extremities. Previous studies using molecular analysis have shown that BSI is caused mainly by mutations in TGM1. Twenty missense mutations have been reported in BSI. Of these 20 missense mutations, nine occurred only in patients with the BSI phenotype and 11 were common to BSI and other types of ARCI. Until recently, there has been no genotype-phenotype correlation. Therefore, the same mutation of the transglutaminase 1 could result in either generalized ARCI or BSI. The present case demonstrates this phenotype in a White Tunisian patient with a novel mutation of TGM1 (I304F) not previously reported in BSI

Bowen’s disease in a patient with Primary Sjögren’s syndrome: A case report and a review of the literature

A rare case of Bowen’s disease (BD) in a patient with Primary Sjögren’s syndrome is reported. A 42-year-old woman suffering from Primary Sjögren’s syndrome retained on the basis of clinical and serological findings, was admitted 3 years later for genital bleeding. The diagnosis of Bowen’s disease was established by clinical and histolopathological examination. Classical association of lymphoma and Sjögren’s syndrome is described, but to the best of our knowledge, it is the second report of BD associated to Sjögren’s syndrome in published literature. A common physio-pathological etiology cannot be excluded