Cytotoxic triterpene saponins from the mangrove <i>Aegiceras corniculatum</i>

<p>Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (<b>1</b>), were isolated from the leaves of the Vietnamese mangrove <i>Aegiceras corniculatum</i>. Their structures were determined by spectroscopic methods such as 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities of the isolated compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), and A549 (adenocarcinoma) cancer cell lines were also evaluated. Strong cytotoxicity was observed for sakurasosaponin (<b>2</b>) against all four cancer cell lines and for sakurasosaponin methyl ester (<b>3</b>) against MCF7, A549, and HCT116 cell lines with IC₅₀ values ranging from 2.89 ± 0.02 to 9.86 ± 0.21 μM.</p

A new rearranged abietane diterpene from <i>Clerodendrum inerme</i> with antioxidant and cytotoxic activities

<p>Eight compounds were isolated from the leaves of <i>Clerodendrum inerme</i>, including one new rearranged abietane diterpene, crolerodendrum B (<b>1</b>). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds <b>1</b>, <b>3</b> and <b>4</b> exhibited strong DPPH radical-scavenging effects (ED₅₀ values of 17.6 ± 2.1, 10.1 ± 0.8 and 11.3 ± 0.3 μM, respectively) and <b>4</b> showed strong cytotoxicity against the HCT116 cell line (IC₅₀ = 3.46 ± 0.01 μM).</p