The CHIME graduate programme in health informatics

In 1999 University College London inaugurated a programme of graduate part-time Health Informatics courses to support the UK National Health Service?s Information for Health strategy. The programme has attracted students from across the UK and abroad, with a diverse range of backgrounds and skills and has proved a challenging and rewarding experience for students and tutors alike. The modular programme aims to provide a thorough grounding in the theory and practice of Health Informatics and addresses important application areas. The guiding principle is that Health Informatics graduates need to understand computers and programming but that, since the majority are not going to become programmers, programming methods should not dominate the curriculum.In the taught phase of the programme students attend college for 3 days a month and complete an assignment each month, based on home study. Students may graduate with a certificate or diploma, or go on to tackle a dissertation leading to an MSc. Research projects have included a patient record system based on speech input, a mathematical model for illustrating to patients the risks associated with smoking, an analysis of Trust staff's preparedness for Information for Health and a patient information leaflet giving advice about drug related information on the Web. As we move towards our fifth intake of students, we are in the process of evaluating our programme and carrying out a follow up study of our graduates? subsequent career pathways

Hunting and sale of Pangolins across Sub-Saharan Africa: a preliminary analysis

Pangolins (Pholidota: Manidae) are hunted and traded for their meat and scales. We conducted preliminary analyses on the hunting and sale at markets of four species of pangolin across Sub-Saharan Africa based on data from the OFFTAKE database. Our analyses show that all four species of African pangolin are hunted and sold at markets throughout much of Sub-Saharan Africa. The proportion of pangolins as part of the total vertebrates hunted has increased significantly during the 43 years, from 1972-2014, for which we have data

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

CLEF is an MRC sponsored project in the E-Science programme that aims to establish policies and infrastructure for the next generation of integrated clinical and bioscience research. One of the major goals of the project is to provide a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies are needed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows and pseudonymisation mechanisms that are currently being developed. Intended constraints and monitoring policies that will apply to research interrogation of the repository are also outlined. Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

Objectives: CLEF is an MRC sponsored project in the E-Science programme that aims to establish methodologies and a technical infrastructure for the next generation of integrated clinical and bioscience research. Methods: The heart of the CLEF approach to this challenge is to design and develop a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies have been developed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. Results: This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows, pseudonymisation measures and additional monitoring policies that are currently being developed. Conclusion: Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii

Several conditions that allow the preservation, storage and rapid, efficient recovery of viable Acanthamoeba castellanii organisms were investigated. The viability of trophozoites (as determined by time to confluence) significantly declined over a period of 12 months when stored at −70°C using dimethyl sulfoxide (DMSO; 5 or 10%) as cryopreservant. As A. castellanii are naturally capable of encystment, studies were undertaken to determine whether induced encystment might improve the viability of organisms under a number of storage conditions. A. castellanii cysts stored in the presence of Mg2+ at 4°C remained viable over the study period, although time to confluence was increased from approximately 8 days to approximately 24 days over the 12-month period. Storage of cysts at −70°C with DMSO (5 or 10%) or 40% glycerol, but not 80% glycerol as cryopreservants increased their viability over the 12-month study period compared with those stored at room temperature. Continued presence of Mg2+ in medium during storage had no adverse effects and generally improved recovery of viable organisms. The present study demonstrates that A. castellanii can be stored as a non-multiplicative form inexpensively, without a need for cryopreservation, for at least 12 months, but viability is increased by storage at −70°C

Causes, Consequences and Prevention of Refrigeration Fires in Residential Dwellings

There are around 300 residential dwelling fires in Great Britain each year where a fridge or freezer is cited as the cause. A number of these incidents have resulted in injuries/fatalities and produced significant levels of property damage. This paper examines the causes and consequences of refrigeration fires in residential dwelling fires in Great Britain (London and England) and the evidence collected via fire investigation of residential dwelling fires involving fridges or freezers. Analysis of the data collected from these fires suggests that, once ignition occurs, fires started by faults in fridge/freezers are more likely to spread beyond both the appliance and the room of origin, and tend to cause more damage than fires started by the other types of white goods appliance (washing machine, dishwasher or tumble dryer). A number of common failure modes leading to ignition in domestic refrigeration fires, along with specific fire escalation and spread mechanism are identified. Based upon the information obtained from fire investigations and a comparison between the design and construction of refrigeration appliances used in Great Britain and USA, a number of recommendations are suggested which could be used to help reduce the risk of domestic refrigeration fires

Ignition of flammable hydrogen/air mixtures by high mass mechanical impact of Magnox contaminated surfaces

Magnox and its corrosion products are a major constituent of some legacy nuclear waste storage silos which generate hydrogen. An experimental study investigates the likelihood of ignition of hydrogen/air when large mass projectiles impact rusty surfaces with Magnox contamination. Ignition is observed with 50kg projectiles impacting a 45º Magnox-smeared rusty anvil plate with KE as low as 40J. Theoretical calculations relating to the angled impacts reveal that they involve substantial tangential energy losses associated with frictional heating of the impact surfaces. It is shown that these energy losses are particularly dependent on the shape of the projectile since projectile geometry determines the radius of gyration and the relationship of centre of gravity to the impact point. In conclusion, the projectile shape is likely to be of greater importance than the mass (i.e. for a given impact energy) because of its direct bearing on the magnitude of the tangential energy loss

Combined Hazard Analyses to Explore the Impact of Liquid Hydrogen Fuel on the Civil Aviation Industry

Interest in green technology in aviation is increasing. To address environmental issues, novel fuels such as cryogenic liquid hydrogen (LH2) are being explored, however there are safety concerns. This work combines safety studies to explore LH2 fuel safety for civil aviation. Preliminary hazard analyses (PHAs) (utilizing over 70 standards and guides) have been performed identifying possible LH2 hazards on-board aircraft. A PHA has also been produced, with industry stakeholder involvement, to understand the major concerns for LH2 use at airports. Gaps in fundamental knowledge and LH2 technology have been identified, and two of these explored. Firstly, work has been started to understand the fundamental flammability of hydrogen in altitude conditions. Secondly, FLACS CFD modelling has been used to simulate large-scale LH2 pool releases to examine behavior and predict pool size, downwind flammable regions, and flammable mass clouds formed for different environmental conditions and release scenarios. This has identified significant effects of wind speed on buoyancy and flammable cloud travel which must be taken into account of any hydrogen fuel facility design. This work (part of the EC funded ENABLEH2 project) is some of the first in over a decade to re-examine the safety of hydrogen propulsion in aircraft. This process has identified wide-ranging issues that must be addressed before hydrogen propulsion can be introduced in civil aviation