Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity

SummaryMitochondrial carrier homolog 2 (MTCH2) is a repressor of mitochondrial oxidative phosphorylation (OXPHOS), and its locus is associated with increased BMI in humans. Here, we demonstrate that mice deficient in muscle MTCH2 are protected from diet-induced obesity and hyperinsulinemia and that they demonstrate increased energy expenditure. Deletion of muscle MTCH2 also increases mitochondrial OXPHOS and mass, triggers conversion from glycolytic to oxidative fibers, increases capacity for endurance exercise, and increases heart function. Moreover, metabolic profiling of mice deficient in muscle MTCH2 reveals a preference for carbohydrate utilization and an increase in mitochondria and glycolytic flux in muscles. Thus, MTCH2 is a critical player in muscle biology, modulating metabolism and mitochondria mass as well as impacting whole-body energy homeostasis

Interlayer Registry Determines the Sliding Potential of Layered Metal Dichalcogenides: The case of 2H-MoS2

We provide a simple and intuitive explanation for the interlayer sliding energy landscape of metal dichalcogenides. Based on the recently introduced registry index (RI) concept, we define a purely geometrical parameter which quantifies the degree of interlayer commensurability in the layered phase of molybdenum disulphide (2HMoS2). A direct relation between the sliding energy landscape and the corresponding interlayer registry surface of 2H-MoS2 is discovered thus marking the registry index as a computationally efficient means for studying the tribology of complex nanoscale material interfaces in the wearless friction regime.Comment: 13 pages, 7 figure

Interlayer Registry to Determine the Sliding Potential of Layered Metal Dichalcogenides: The Case of <i>2H</i>-MoS₂

We provide a simple and intuitive explanation for the interlayer sliding energy landscape of metal dichalcogenides. On the basis of the recently introduced registry index (RI) concept, we define a purely geometrical parameter that quantifies the degree of interlayer commensurability in the layered phase of molybdenum disulfide (<i>2H</i>-MoS₂). A direct relation between the sliding energy landscape and the corresponding interlayer registry surface of <i>2H</i>-MoS₂ is discovered. A simple fit of the model parameters to capture the sliding energy landscape obtained at different external loads enables the identification and isolation of the prominent interlayer interactions dictating the interlayer sliding physics under different tribological scenarios. The success of our method in capturing the results of complex quantum mechanical calculations along with its high computational efficiency marks the RI as a promising tool for studying the tribology of complex nanoscale material interfaces in the wearless friction regime