Additional file 2 of Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study

: Figure S1. Comparisons of (A)PFS and (B) OS according to the tumor grade in patients receiving EGFR-TKIs. We could not find significant difference depending on histologic types in comparison of PFS and OS. Tumor was graded as follows. The low-grade group includes lepidic type, the intermediate-group includes acinar and papillary types, and the high-grade group includes micropapillary and solid type. (TIF 3615 kb

Additional file 1 of Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study

: Table S1. Classification of histopathologic subtype according to smoking status in EGFR-positive lung adenocarcinoma. The proportion of solid type in the ever- smoker is higher than that in never smoker. (DOCX 17 kb

pH-Dependent Conformations for Hyperbranched Poly(ethylenimine) from All-Atom Molecular Dynamics

Hyperbranched poly­(ethylene imine) (PEI) with its high amino content is a versatile functional polymer that is widely used as a gene delivery vector in biological applications and as a ligand and precursor for ion exchange resins and membranes in water purification and metal recovery. We report here the first fully atomistic model of a 25 kDa hyperbranched PEI macromolecule. We utilized this model to carry out molecular dynamics (MD) simulations with explicit water molecules and chloride ions to study pH-dependent conformational changes. We find that growing the PEI macromolecule sequentially from the monomers yields atomistic structures whose sizes (radius of gyration) are in good agreement with the small angle neutron scattering experiments. Our analysis of the structural properties from MD simulations shows that conformations of the hyperbranched PEI exhibit oblate ellipsoidal elongation at low pH compared to high or neutral pH but with no significant changes in the corresponding sizes. This fully atomistic model of a 25 kDa hyperbranched PEI macromolecule in water provides much needed detailed atomistic information for advancing our fundamental understanding of the structures and host–guest properties of PEI-based functional reagents and materials for biomedical and sustainability related applications

Additional file 1: of Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics

Table S1. Cytokine concentration in the atopic and non-atopic groups. Table S2. Different expression of the measured parameters among the normal age groups (DOCX 16 kb

Additional file 1: of Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment

Table S1. Association between hippocampus dose and neurocognitive test deterioration. (DOCX 20 kb

Additional file 1: Figure S1. of Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

Sac-1004 increases HBMEC survival. HBMECs were starved and treated with various concentrations of Sac-1004. Chemical structure of Sac-1004 (A). Cell survival was detected using an MTT assay (B). Under the same experimental conditions, cell viability was also determined by microscopy after incubation for 48 h (C). All data are presented the means ± SEM. ***P < 0.001. (JPG 82 kb