16 research outputs found

    Mudanças evolutivas no tratamento da doença de Graves com iodo radioativo: 12 anos de experiĂȘncia em um hospital universitĂĄrio Changing trends in the treatment of Graves' disease with radioiodine: a 12-year experience in a university hospital

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    OBJETIVO: Avaliar a mudança no perfil e abordagem dos pacientes com doença de Graves submetidos a dose terapĂȘutica de radioiodo. MATERIAIS E MÉTODOS: Avaliamos, retrospectivamente, 226 pacientes portadores de doença de Graves submetidos a dose terapĂȘutica de radioiodo entre janeiro de 1990 e dezembro de 2001. O perĂ­odo de 12 anos foi dividido em trĂȘs perĂ­odos de 4 anos para fins de anĂĄlise estatĂ­stica, sendo comparadas variĂĄveis clĂ­nicas e laboratoriais nos perĂ­odos descritos. RESULTADOS: Constatamos que o nĂșmero de pacientes encaminhados para a dose terapĂȘutica, assim como o percentual de pacientes do sexo feminino (de 62% para 86%; p = 0,005), tiveram incremento significativo. Houve aumento significativo no percentual de pacientes em uso de metimazol previamente Ă  dose terapĂȘutica (de 9,1% para 35,6%; p = 0,03). A dose mĂ©dia de iodo administrada tambĂ©m teve incremento significativo (de 7,6 mCi para 12,7 mCi; p = 0,000003), com reflexo direto em um maior percentual de pacientes curados (de 55,6% para 83,7%; p = 0,004) um ano pĂłs-dose terapĂȘutica. CONCLUSÃO: A dose terapĂȘutica de radioiodo tem sido um mĂ©todo cada vez mais aceito nos pacientes com doença de Graves e a dose administrada tem sido cada vez maior, no intuito de cura permanente e diminuição das chances de recidiva.<br>OBJECTIVE: To evaluate the changes in clinical parameters and in the approach to patients submitted to radioiodine therapy for Graves' disease. MATERIALS AND METHODS: Dossiers of 226 patients submitted to radioiodine therapy for Graves' disease in the period between January 1990 and December 2001 were retrospectively evaluated. For the purposes of statistical analysis, the 12-year period was subdivided into three periods of 4 years, with a comparison of clinical and laboratory variables in these periods. RESULTS: The authors have observed that the total number of patients referred for radioiodine therapy as well as the percentage of female patients presented a significant increase (from 62% to 86%; p = 0.005). The percentage of patients pretreated with methimazole before radioiodine therapy increased significantly (from 9.1% to 35.6%; p = 0.03). The mean radioiodine dose delivered has also presented a significant increase (from 7.6 mCi to 12.7 mCi; p = 0.000003) with a direct reflection on a higher percentage of patients cured one year after the radioiodine therapy (from 55.6% to 83.7%; p = 0.004). CONCLUSION: Radioiodine therapy has increasingly been accepted for treatment of patients with Graves' disease and the doses delivered have increased to achieve a permanent cure as well as a reduction of the chances of recurrence
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