Successful Treatment of a Mixed Neuroendocrine-Nonneuroendocrine Neoplasm of the Colon with Metastases to the Thyroid Gland and Liver

Patients with mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) of the colon have poor prognosis. Herein, we report a patient with MiNEN of the colon with metastases to the liver and the thyroid gland, with long-term survival. A 45-year-old man presented with anterior neck swelling. Histopathological examination of the thyroid tumor revealed neuroendocrine carcinoma (NEC), suggesting that a primary NEC in another organ had metastasized to the thyroid gland. Computed tomography to identify a primary NEC revealed two tumors: one in the liver and one in the transverse colon. A biopsy revealed that the histopathology of the liver and colon tumors was NEC and adenocarcinoma, respectively. Thereafter, the patient underwent surgical resection of the colon tumor and was finally diagnosed as colon MiNEN with metastases to the thyroid and liver. The surgical resection of the metastatic liver tumor was performed after several courses of systemic chemotherapy, and the patient survives presently without any recurrence for approximately seven years after the diagnosis. Surgical resection of each metastatic lesion combined with systematic chemotherapy apparently improved the prognosis of MiNEN of the colon with distant metastases

Release of nitrogen and phosphorus from aquaculture farms to Selangor River, Malaysia

The release of nitrogen and phosphorus from aquaculture ponds to Selangor River, Malaysia was estimated. The concentrations of nitrogen and phosphorus in aquaculture ponds were always higher than those in the river, their primary water source, indicating that the aquaculture ponds are sources of nitrogen and phosphorus in Selangor River. From the careful interview with aquaculture managers, the frequency of water exchange, the number of harvesting, and the amount of feeds added, the total volume of water released to the Selangor River was also obtained. The total amount of nitrogen and phosphorus added to each aquaculture pond was estimated to be about 700 kg N and 60 kg P per year, respectively. About 100-200 kg N and 10-15 kg P were estimated to be released with the waste water per pond per year, accounting for 20-30% of nitrogen and phosphorus in added feeds. It is important for us to precisely estimate the fates of nutrients for the better management and sustainable development of aquaculture industries. Our data may help to improve aquaculture management in future

Annual Parallax Distance to the K-type star system IRAS 22480+6002 measured with VERA

We present the astrometric VLBI observations of water masers associated with IRAS 22480+6002 (IRC+60370, hereafter I22480) with the VLBI Exploration of Radio Astrometry (VERA). The stellar type of I22480 looks unusual as a stellar maser source and has been debated since the 1970s. We successfully determined the annual parallax of a group of the water maser spots, pi=0.400+/-0.025 mas, corresponding to a distance to I22480 of D=2.50 /+0.17/-0.15 kpc. This suggests that the estimated bolometric luminosity of I22480 should be revised to 35 000 L_sun, favoring a K-type supergiant rather than an RV Tau-type variable star previously suggested. Although the spectral type is unusual as a stellar maser source, the internal motions of the water maser features suggest that the water masers are associated with the circumstellar envelope of this star. Taking into account a possible stellar motion with respect to the maser feature motions, we derived a secular proper motion of I22480, (mu_alpha, mu_delta)=(-2.58+/-0.33, -1.91+/-0.17) [mas yr^-1]. The derived motion of I22480 in the Milky Way has a deviation by ~ -30 km/s in the galactic azimuthal direction from a circular motion estimated from the galactocentric distance to I22480 and assumption of a flat Galactic rotation curve. This peculiar motion is still comparable to those typically seen in the water maser sources located in the Perseus spiral arm. Taking into account the peculiar motion and the proximity to the Galactic midplane (z ~60 pc), I22480 may be a member of the Galactic thin disk.Comment: 11 pages, 7 figures, accepted by PASJ (issue on vol. 65, No.1). Figure formats were correcte

Spatiotemporal T790M Heterogeneity in Individual Patients with EGFR-Mutant Non–Small-Cell Lung Cancer after Acquired Resistance to EGFR-TKI

IntroductionEpidermal growth factor receptor (EGFR) mutation T790M accounts for approximately half of acquired resistances to EGFR-tyrosine kinase inhibitor (TKI). Because T790M is mediated by TKI exposure, its penetration and “on–off” may affect T790M status.MethodsWe retrospectively reviewed T790M status and clinical course of patients who had undergone multiple rebiopsies after acquired resistance to EGFR-TKI.ResultsOf 145 patients with EGFR-mutant NSCLC receiving rebiopsy after acquired resistance, 30 underwent multiple site rebiopsies, and 24 received repeated rebiopsies at the same lesion. In 22 patients who underwent rebiopsies from both central nervous system (CNS; 20 cerebrospinal fluids [CSF] and 2 brain tumoral tissues) and thoracic lesions (7 lung tissues, 14 pleural effusions, and 1 lymph node), 12 were thoracic-T790M-positive. Of these 12 patients, 10 were CNS-T790M-negative, despite exhibiting thoracic-T790M-positive. All 10 thoracic-T790M-negatives were CNS-T790M-negative. Three patients revealed a spatial heterogeneous T790M status among their thoracic lesions. In 24 patients receiving repeated rebiopsies at the same lesion (12 lung tissues, 6 CSFs, and 6 pleural effusions), T790M status of lung lesions varied in five patients after TKI-free interval. In all five patients whose T790M status changed from positive to negative, EGFR-TKI rechallenge was effective. In three of these five patients, after further TKI exposure, T790M status changed from negative to positive again. There was also a patient whose CSF T790M status changed from negative to positive after high-dose erlotinib therapy.ConclusionsT790M status in an individual patient can be spatiotemporally heterogeneous because of selective pressure from EGFR-TKI

Seasonal changes of nutrient distributions along Selangor River, Malaysia

Water samples were taken six times along Selangor River between January 2014 and May 2015 in order to estimate the nutrient changes in different seasons. In the upstream, the nutrient concentrations were higher during the wet period compared to the dry due to the nutrient loading from the eroded soils. Aquaculture ponds could also contribute to the nutrient elevation. Nearly 10 % of the increased nutrients between two sampling stations could come from the aquaculture waste. The relatively high ammonia concentrations were observed in the lower part of Selangor River due to a significant input of ex-mining ponds water and one major arm river which flows through large towns. Our results showed the water quality of Selangor River is clean enough to be suitable for drinking water, but the further study of other parameters such as heavy metals is necessary to ensure the water quality of Selangor River