12 research outputs found

    Interactions in improvised music: people at play

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    Interactions in improvised music: people at play This project began as an open exploration of musical interactions in a trio in which I have played bass for many years. We gave three concerts for the project and I explored our interactions by talking with the pianist/bandleader and drummer after each concert. They described a broad range of interactions and explored a number of different conceptions of what entails a musical interaction. The musicians were keen to talk about the factors that motivate them to perform together, mainly the desire to play. Play, for them, is its own reward. They aim to collaborate in the moment of performance to create something fresh, rather than display their instrumental technique or present music that has been preconceived. An appreciation of this motivation is needed to understand their interactions in concert. Audience members were also interviewed after every performance. They each experienced the concerts differently, in a way that reflects their preoccupations and interests as much as it reflects the concert event. The research thus provides a view of individuals and their differences that contrasts with the body of music research focused on common experiences within particular musical cultures and the acquisition of the skills required to participate in those cultures. This practice-led research project was allowed to develop and find focus gradually in cycles of performances, interviews and analysis of interview transcripts, concurrent with an ongoing exploration of texts about doing research. Various interactions – during the performances and interviews, between the researcher and the interview transcripts and between the researcher and research texts – contributed to the project’s development. These interactions can be thought of as play between foreknowledge and the unknown. Accordingly, play as described by the musicians and as defined in hermeneutics, was actively pursued as a way of developing an appropriate methodology for the project

    Cryptococcus neoformans complex: molecular, clinical and in-vitro studies.

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    Contains fulltext : 128930.pdf (publisher's version ) (Open Access)Radboud Universiteit Nijmegen, 27 augustus 2014Promotores : Voss, A., Verweij, P.E. Co-promotores : Meis, J.F.G.M., Hagen, F

    Fatal Cryptococcus gattii genotype AFLP5 infection in an immunocompetent Cuban patient.

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    Contains fulltext : 125455.pdf (publisher's version ) (Open Access

    Microsatellite typing and susceptibilities of serial Cryptococcus neoformans isolates from Cuban patients with recurrent cryptococcal meningitis

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    Background: Cryptococcus neoformans is commonly associated with meningoencephalitis in immunocompromised patients and occasionally in apparently healthy individuals. Recurrence of infection after initial treatment is not uncommon. We studied C. neoformans isolates from 7 Cuban patients with recurrent cryptococcal meningitis. Antifungal susceptibility and genotyping with microsatellite molecular typing were carried out. Methods: Isolates (n = 19) were recovered from cerebrospinal fluid, blood, urine and semen. Antifungal susceptibilities for amphotericin B, fluconazole, flucytosine, itraconazole, voriconazole, posaconazole and isavuconazole were tested by CLSI M27A3 broth microdilution method. Genotyping was done using a panel of 9 microsatellite (STR) markers: (CT)n, (TG)n, (TA)n, (CTA)n, (TCT)n, (CCA)n, (TTAT)n, (ATCC)n and (TATT)n. Results: The average number of isolates/patient was 2.71. The mean time interval between the collection of any two isolates was 52.5 days. All strains were identified as C. neoformans var. grubii (serotype A alpha). Although none of the strains were resistant to the studied drugs, in serial isolates from two patients, MICs values of triazoles increased 4-5 log(2) dilutions over time. STR patterns showed 14 distinctive profiles. In three patients the recurrent infection was associated with genotypically identical isolates. The four other patients had relapse isolates which were genotypically different from the initial infecting strain. Conclusion: Recurrences of cryptococcal meningitis in our series of patients was not associated with development of drug resistance of the original strain but by an initial infection with different strains or a reinfection with a new strain

    Kodamaea (Pichia) ohmeri fungemia in a pediatric patient admitted in a public hospital

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    Kodamaea (Pichia) ohmeri is a yeast species that has not been reported to be a frequent cause of human infections. The current report describes a case of fungemia caused by K. ohmeri in a 3-year-old female patient hospitalized in the public hospital Maria Alice Fernandes, Natal, RN, Brazil. The patient had previously received antimicrobial therapy due to a peritoneal infection and nosocomial pneumonia, and had a central venous catheter implanted. Kodamaea ohmeri was isolated from blood and the tip of the catheter, 48 h after its implantation. The yeast was identified by standard microbiological methods and sequence analysis of the D1/D2 domains and the ITS 1 + 2 spacer regions of the ribosomal DNA. On CHROMagar Candida medium, the isolate showed a color change from pink to blue. The yeast was susceptible to amphotericin B, and liposomal AmB was used successfully to clear the infection
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