The Role Of P501s And Psa In The Diagnosis Of Metastatic Adenocarcinoma Of The Prostate

[No abstract available]335723724Xu, J., Kalos, M., Stolk, J.A., Zasloff, E.J., Zhang, X., Houghton, R.I., Identification and characterization of prostein, a novel prostate-specific protein (2001) Cancer Res, 61, pp. 1563-1568Xu, J., Stolk, J.A., Zhang, X., Silva, S.J., Houghton, R.I., Matsumura, M., Identification of differentially expressed genes in human prostate cancer using subtraction and microarray (2000) Cancer Res, 60, pp. 1677-1682Zhou, M., Chinnaiyan, A.M., Kleer, C.G., Lucas, P.C., Rubin, M.A., Alpha-Methylacyl-CoA racemase: A novel tumor marker over-expressed in several human cancers and their precursor lesions (2002) Am J Surg Pathol, 26, pp. 926-93

Bronchus-associated lymphoid tissue in kabuki syndrome with associated hyper-IgM syndrome/common variable immunodeficiency

A 28-year-old woman with a medical history significant for Kabuki syndrome with associated hyper-IgM syndrome/common variable immunodeficiency presented with a 3-month history of dyspnea, pleuritic pain, and nonproductive cough. Imaging demonstrated nodular infiltrates increasing toward the lung bases (Figure 1A). Bronchoscopy with lavage and transbronchial biopsies was performed to evaluate for an infectious or inflammatory etiology; however, results were unrevealing, and no infectious etiology was identified. Therefore, she underwent a video-assisted thoracic surgery biopsy that demonstrated nodular lymphoid hyperplasia with follicles centered on small airways and areas of organizing pneumonia (Figure 1B). Immunostains demonstrated follicles composed of CD31 T cells and CD201 B cells (Figure 1B) and no morphologic evidence of lymphoma or plasma cell neoplasm. Results were consistent with bronchus-associated lymphoid tissue (BALT). High-dose steroids were administered without resolution of symptoms or radiographic findings. A report of effective responses with rituximab and azathioprine in patients with common variable immunodeficiency who had a similar inflammatory lung process containing tertiary lymphoid structures, granulomas, and organizing pneumonia has been published (1). After four doses of rituximab (weekly), together with the initiation of azathioprine, her symptoms and radiographic findings improved (Figure 1C)