Advances in vascular anatomy and pathophysiology using high resolution and multiparametric sonography

: B-mode and Color Doppler are the first-line imaging modalities in cardiovascular diseases. However, conventional ultrasound (US) provides a lower spatial and temporal resolution (70-100 frames per second) compared to ultrafast technology which acquires several thousand frames per second. Consequently, the multiparametric ultrafast platforms manage new imaging algorithms as high-frequency ultrasound, contrast-enhanced ultrasound, shear wave elastography, vector flow, and local pulse wave imaging. These advances allow better ultrasound performances, more detailed blood flow visualization and vessel walls' characterization, and many future applications for vascular viscoelastic properties evaluation.In this paper, we provide an overview of each new technique's principles and concepts and the real or potential applications of these modalities on the study of the artery and venous anatomy and pathophysiology of the upper limb before and after creating a native or prosthetic arterio-venous fistula. In particular, we focus on high-frequency ultrasound that could predict cannulation readiness and its potential role in the venous valvular status evaluation before vascular access creation; on contrast-enhanced ultrasound that could improve the peri-operative imaging evaluation during US-guided angioplasty; on shear wave elastography and local pulse wave imaging that could evaluate preoperative vessels stiffness and their potential predictive role in vascular access failure; on vector flow imaging that could better characterize the different components of the vascular access complex flow

Earths in Other Solar Systems N-body simulations: the Role of Orbital Damping in Reproducing the Kepler Planetary Systems

The population of exoplanetary systems detected by Kepler provides opportunities to refine our understanding of planet formation. Unraveling the conditions needed to produce the observed exoplanets will sallow us to make informed predictions as to where habitable worlds exist within the galaxy. In this paper, we examine using N-body simulations how the properties of planetary systems are determined during the final stages of assembly. While accretion is a chaotic process, trends in the ensemble properties of planetary systems provide a memory of the initial distribution of solid mass around a star prior to accretion. We also use EPOS, the Exoplanet Population Observation Simulator, to account for detection biases and show that different accretion scenarios can be distinguished from observations of the Kepler systems. We show that the period of the innermost planet, the ratio of orbital periods of adjacent planets, and masses of the planets are determined by the total mass and radial distribution of embryos and planetesimals at the beginning of accretion. In general, some amount of orbital damping, either via planetesimals or gas, during accretion is needed to match the whole population of exoplanets. Surprisingly, all simulated planetary systems have planets that are similar in size, showing that the "peas in a pod" pattern can be consistent with both a giant impact scenario and a planet migration scenario. The inclusion of material at distances larger than what Kepler observes has a profound impact on the observed planetary architectures, and thus on the formation and delivery of volatiles to possible habitable worlds.Comment: Resubmitted to ApJ. Planet formation models available online at http://eos-nexus.org/genesis-database

Ultrasound Guidance in Paravertebral Injections of Oxygen-Ozone: Treatment of Low Back Pain

Background: Paravertebral injection of ozone is an established clinical practice for the treatment of Low Back Pain (LBP). The role of Ultrasound Guidance (USG) in mini invasive procedures has become important in many clinical practice thanks to the greater precision this technique can add. As matter of fact, a large volume of ozone in a single administration may have some adverse or side effects. In this study we wanted to verify if the use of USG in Oxygen/ Ozone (O2/O3) infiltrations could allow the administration of a smaller volume of gas mixture, increasing the safety and the comfort of the procedure itself, obtaining however similar or better results in pain decrease. Methods: We compared two groups of 25 patients affected by LBP, undergoing 10 infiltrations of O2/O3, by using USG (group U) or only anatomical landmarks (group AL). Pain intensity, by calculating Visual Analogical Scale (VAS) difference before and after the treatment, and the discomfort were evaluated in both groups. Results: The mean of the VAS before the treatment was 6.44 in group U and 6.48 in group AL. The mean of the VAS after the treatment was 2.22 in group U and 3.04 in group AL. The mean of discomfort rate was 2.84 in group U and 5.44 in group AL. The number of patients with unbearable discomfort was 0 in group U and 7 in group AL. Conclusions: As many other treatment, also paravertebral injections of O2/O3 benefits of the advantages of the US device which makes this treatment safer and more accurate

Elementary Teacher Candidates’ Flexibility with Comparing Fractions

The teaching and learning of fractions have been persistent challenges, and data on national assessments continue to show students’ difficulties with fractions. The Common Core State Standards have provided a new lens for the study of fractions, and with it a need to update teacher candidates’ mathematical knowledge for teaching. Fractions are a challenge for mathematics teacher educators working with teacher candidates. Exploring instructional approaches to building teacher candidate understanding is important. Technology could play an important role in building robust teacher candidates’ conceptual understanding of fractions. Whitacre & Nickerson’s (2016) framework provides background knowledge for exploring whether technology can promote flexible strategies for comparing fractions. In this study, we examine the impact on teacher candidates’ flexibility with solving fraction comparison problems through the use of a sequenced set of interactive dynamic technology-based learning experiences modeling the approach advocated in the Common Core Standards. Keywords: fractions, technology, elementary teacher DOI: 10.7176/JEP/11-9-01 Publication date:March 31st 2020

Coherent electronic and nuclear dynamics in a rhodamine heterodimer-DNA supramolecular complex

Elucidating the role of quantum coherences in energy migration within biological and artificial multichromophoric antenna systems is the subject of an intense debate. It is also a practical matter because of the decisive implications for understanding the biological processes and engineering artificial materials for solar energy harvesting. A supramolecular rhodamine heterodimer on a DNA scaffold was suitably engineered to mimic the basic donor-acceptor unit of light-harvesting antennas. Ultrafast 2D electronic spectroscopic measurements allowed identifying clear features attributable to a coherent superposition of dimer electronic and vibrational states contributing to the coherent electronic charge beating between the donor and the acceptor. The frequency of electronic charge beating is found to be 970 cm-1 (34 fs) and can be observed for 150 fs. Through the support of high level ab initio TD-DFT computations of the entire dimer, we established that the vibrational modes preferentially optically accessed do not drive subsequent coupling between the electronic states on the 600 fs of the experiment. It was thereby possible to characterize the time scales of the early time femtosecond dynamics of the electronic coherence built by the optical excitation in a large rigid supramolecular system at a room temperature in solution. © 2017 the Owner Societies.Multi valued and parallel molecular logi

An ALMA Survey of faint disks in the Chamaeleon I star-forming region: Why are some Class II disks so faint?

ALMA surveys of nearby star-forming regions have shown that the dust mass in the disk is correlated with the stellar mass, but with a large scatter. This scatter could indicate either different evolutionary paths of disks or different initial conditions within a single cluster. We present ALMA Cycle 3 follow-up observations for 14 Class II disks that were low S/N detections or non-detections in our Cycle 2 survey of the $\sim 2$ Myr-old Chamaeleon I star-forming region. With 5 times better sensitivity, we detect millimeter dust continuum emission from six more sources and increase the detection rate to 94\% (51/54) for Chamaeleon I disks around stars earlier than M3. The stellar-disk mass scaling relation reported in \citet{pascucci2016} is confirmed with these updated measurements. Faint outliers in the $F_{mm}$--$M_*$ plane include three non-detections (CHXR71, CHXR30A, and T54) with dust mass upper limits of 0.2 M$_\oplus$ and three very faint disks (CHXR20, ISO91, and T51) with dust masses $\sim 0.5$ M$_\oplus$. By investigating the SED morphology, accretion property and stellar multiplicity, we suggest for the three millimeter non-detections that tidal interaction by a close companion ($<$100 AU) and internal photoevaporation may play a role in hastening the overall disk evolution. The presence of a disk around only the secondary star in a binary system may explain the observed stellar SEDs and low disk masses for some systems.Comment: ApJ accepte

Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.

The DNA-damage checkpoint kinase Chk1 is essential in higher eukaryotes due to its role in maintaining genome stability in proliferating cells. CHK1 gene deletion is embryonically lethal, and Chk1 inhibition in replicating cells causes cell-cycle defects that eventually lead to perturbed replication and replication-fork collapse, thus generating endogenous DNA damage. What is the cause of replication-fork collapse when Chk1 is inactivated, however, remains poorly understood. Here, we show that generation of DNA double-strand breaks at replication forks when Chk1 activity is compromised relies on the DNA endonuclease complex Mus81/Eme1. Importantly, we show that Mus81/Eme1-dependent DNA damage--rather than a global increase in replication-fork stalling--is the cause of incomplete replication in Chk1-deficient cells. Consequently, Mus81/Eme1 depletion alleviates the S-phase progression defects associated with Chk1 deficiency, thereby increasing cell survival. Chk1-mediated protection of replication forks from Mus81/Eme1 even under otherwise unchallenged conditions is therefore vital to prevent uncontrolled fork collapse and ensure proper S-phase progression in human cells