Measurement and clinical significance of biomarkers of oxidative stress in humans

Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants. We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans. There is a lack of consensus concerning the validation, standardization, and reproducibility of methods for the measurement of the following: (1) ROS in leukocytes and platelets by flow cytometry, (2) markers based on ROS-induced modifications of lipids, DNA, and proteins, (3) enzymatic players of redox status, and (4) total antioxidant capacity of human body fluids. It has been suggested that the bias of each method could be overcome by using indexes of oxidative stress that include more than one marker. However, the choice of the markers considered in the global index should be dictated by the aim of the study and its design, as well as by the clinical relevance in the selected subjects. In conclusion, the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions

A variational method for second order shape derivatives

We consider shape functionals obtained as minima on Sobolev spaces of classical integrals having smooth and convex densities, under mixed Dirichlet-Neumann boundary conditions. We propose a new approach for the computation of the second order shape derivative of such functionals, yielding a general existence and representation theorem. In particular, we consider the p-torsional rigidity functional for p grater than or equal to 2.Comment: Submitted paper. 29 page

Hydrophobic and hydrophilic au and ag nanoparticles. Breakthroughs and perspectives

This review provides a broad look on the recent investigations on the synthesis, characterization and physico-chemical properties of noble metal nanoparticles, mainly gold and silver nanoparticles, stabilized with ligands of different chemical nature. A comprehensive review of the available literature in this field may be far too large and only some selected representative examples will be reported here, together with some recent achievements from our group, that will be discussed in more detail. Many efforts in finding synthetic routes have been performed so far to achieve metal nanoparticles with well-defined size, morphology and stability in different environments, to match the large variety of applications that can be foreseen for these materials. In particular, the synthesis and stabilization of gold and silver nanoparticles together with their properties in different emerging fields of nanomedicine, optics and sensors are reviewed and briefly commented

From the Drinfeld realization to the Drinfeld-Jimbo presentation of affine quantum algebras: the injectivity

In this paper the surjective homomorphism from the Drinfeld realization to the Drinfeld and Jimbo presentation of affine quantum algebras is proved to be injective. A consequence of the arguments used in the paper is the triangular decomposition of the Drinfeld realization of affine quantum algebras also in the twisted case. A presentation of the affine Kac-Moody algebras in terms of the "Drinfeld generators" is also provided