SPREAD OF HELICOBACTER PYLORI — INFECTION AMONG ADOLESCENTS AND OPPORTUNITIES TO INCREASE EFFICACY OF ITS TREATMENT

The article highlights the data on the spread of Helicobacter pylori (НР) infection among adolescents aged 15–17, its associations with the pathology of the gastroduodenal zone and eradication therapy efficacy. They showed that НР-infection was disc closed among 70% of adolescents, residing in a large industrial city and in 99% of cases it was accompanied by the clinical symptoms of stomach and duodenum lesions. Adolescents without heliconbacteriosis of the gastro duodenal zone showed symptoms of the given diseases only in 16.4% of cases. НР associated and НР cnonassociated changes in the stomach and duodenum mucous tunic among the examined patients were reversible. Successful eradication of H. pylori along with the first line therapy was achieved among 50–60% of adolescents. Introduction of the mixture of bacteria lysates to the treatment was accompanied by the eradication of H. pylori among 95% of the examined patients. Thus, the application of the above said mixture in addition to the commonly accepted scheme of treatment for НР associated diseases of the gastro duodenal zone increases its efficacy, which allows the authors to recommend the immunomodulator for the combined therapy of НР-infection.Key Words: Adolescents, Helicobacter Pylori, Treatment, Mixture of Bacteria Lysates

SPREAD OF HELICOBACTER PYLORI — INFECTION AMONG ADOLESCENTS AND OPPORTUNITIES TO INCREASE EFFICACY OF ITS TREATMENT

The article highlights the data on the spread of Helicobacter pylori (НР) infection among adolescents aged 15–17, its associations with the pathology of the gastroduodenal zone and eradication therapy efficacy. They showed that НР-infection was disc closed among 70% of adolescents, residing in a large industrial city and in 99% of cases it was accompanied by the clinical symptoms of stomach and duodenum lesions. Adolescents without heliconbacteriosis of the gastro duodenal zone showed symptoms of the given diseases only in 16.4% of cases. НР associated and НР cnonassociated changes in the stomach and duodenum mucous tunic among the examined patients were reversible. Successful eradication of H. pylori along with the first line therapy was achieved among 50–60% of adolescents. Introduction of the mixture of bacteria lysates to the treatment was accompanied by the eradication of H. pylori among 95% of the examined patients. Thus, the application of the above said mixture in addition to the commonly accepted scheme of treatment for НР associated diseases of the gastro duodenal zone increases its efficacy, which allows the authors to recommend the immunomodulator for the combined therapy of НР-infection.Key Words: Adolescents, Helicobacter Pylori, Treatment, Mixture of Bacteria Lysates.</strong

Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0. 05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control. © 2010 Pleiades Publishing, Ltd

Wound healing potential of chitosan and N-sulfosuccinoyl chitosan derivatives

Comparative study of chitosan wound healing properties and its synthesized derivatives in MC-100 gel was carried out using the model of experimental full thickness skin wounds. It was determined that N-sulfosuccinoyl chitosan derivatives added into the gel in a concentration of 0. 05% possess the higher wound healing activity in comparison with other chitosan derivatives and decrease the half-healing period of wounds 2-3 times in comparison with the control. © 2010 Pleiades Publishing, Ltd