Исследовнаие термической стабильности 4-метилфениЛ-О-?-Д-глюкопиранозид, методом ТГ-ДСК-ДТА-МС

Были получены данные о термической стабильности 4-метилфенил-О-β-Д-глюкопиранозид. Данная субстанция обладает диуретическим эффектом сравнимым с современными диуретиками. Исследование термической стабильности проводили методом ТГ-ДСК-МС в инертной атмосфере аргона, в интервале температур 25‒600 С°. Из полученных дериватограмм можно сделать вывод, что термическая стабильность субстанции соизмерима с термической стабильностью современных диуретиков. Был предположен механизм термического разложения субстанции и выявлены химические маркеры данного процесса

Chronology and function of a new circular mammoth bone structure from Kostenki 11

This is the author accepted manuscript. The final version is available from Cambridge University Press via the DOI in this record.We report on assemblages of charcoal, burnt bone and microlithic debitage retrieved by flotation from a new circular mammoth bone feature discovered at Kostenki 11-Ia, Russian Federation, the first time a mammoth bone circle has ever been systematically sampled in this way. New radiocarbon dates are used to provide the first coherent chronology for the site, revealing it as one of the oldest such features on the Russian Plain and confirming occupation of this region during Greenland Stadial 3 at the onset of the last glacial maximum. Implications for human activity within and around the mammoth bone feature are discussed.Leverhulme Trus

Surface structure of commercially pure VT1-0 titanium irradiated by an intense pulsed electron beam

It is shown that pulsed electron beam irradiation of commercially pure titanium at a beam energy density of 10 J/cm{2}, pulse duration of 150 [mu]s, number of pulses of N=5 pulses, and pulse repetition frequency of 0.3 Hz with attendant polymorphic [alpha]->[beta]->[ alpha] transformations allows a more than five-fold decrease in the grain and subgrain sizes of the material structure

The effect of post-procedure care on the effectiveness of skin restoration and correction of side effects after aesthetic procedures

Introduction. The  duration of  the  skin  healing period and the  final result of  cosmetic procedures are influenced not only by the treatment protocol and the type of therapy chosen, but also by skin care in the early post-treatment period.Aim of study. Тo study the effectiveness and safety of the use of the topical agent “Traumeel® Cosmo gel” in patients in the early post-treatment period after cosmetic procedures, accompanied by traumatization of the skin.Materials and methods. 20 female patients aged 19 to 49 years, who sought help for the correction of age-related skin changes, acne vulgaris, scarring of the skin and received the procedure of cosmetological therapy, accompanied by damage to the skin. All patients were assigned to group 1 (20 patients). Depending on the method of cosmetological treatment, the external remedy “Traumeel® Cosmo gel” was applied from 2 to 3 times a day at the treated area for 7 ± 2 days.Results. According to the patients’ assessment of the effectiveness and comfort of the treatment, the use of the “Traumeel® Cosmo gel” in  the  early post-treatment period is an effective and safe method of  regenerative therapy of  the  skin  and has a  high therapeutic effectiveness, which was confirmed by the results of the study.Conclusions. Based on the results of the evaluation of the effectiveness by the doctor and patients, as well as the evaluation of the monitoring of the dermatological status, the quality of life index, the patient’s subjective assessment of their response to therapy, consider the therapeutic effectiveness to be high, significantly contributing to the improvement of the quality of life

Optimization of Mixed Fluid Cascade Natural Gas Liquefaction Plant Feed Stream Pressure

This paper presents the results of a study on optimising the feed stream pressure of the Mixed Fluid Cascade natural gas liquefaction cycle. The objective is to optimise the pressure of the feed stream to distribute heat effectively over the cooling stages and reduce the energy cost of the cycle. To achieve the goal, the following tasks have been done: constructing the mathemati-cal model of the cycle, performing the calculation experiment for different values of the feed stream pressure to determine energy characteristic values, and determining the optimal values of feed stream pressure. The flow characteristics of the working substances in the cycle are deter-mined based on the Peng–Robinson–Stryjek–Vera equations of state and Benedict–Webb–Rubin. The mass flow of the working substance is calculated for each cycle's stage heat load, at both constant and different values of the working point temperatures. The distribution of heat load for liquefying 1 kg of natural gas by stages is displayed, and achievable working point tem-peratures of the feed flow are determined. The energy consumed by the compressor units and the amount of compression heat dissipated are calculated. The study's main finding is that the optimal feed pressure in the Mixed Fluid Cascade cycle is higher than the standard pressure. The significance of the obtained results lies in the significant reduction of energy costs of the Mixed Fluid Cascade cycle at a feed stream pressure of 13 MPa

The Post-AGB Star IRAS 07253-2001: Pulsations, Long-Term Brightness Variability and Spectral Peculiarities

The observations and comprehensive study of intermediate initial mass stars at the late stages of evolution, and after the asymptotic giant branch (AGB) in particular, are of crucial importance to identify the common properties for the stars of given group and to reveal binaries among them. This work aims to investigate photometric and spectral peculiarities of a poorly studied post-AGB candidate and infrared source IRAS 07253-2001. We present the new multicolour $UBVR_{C}I_{C}YJHK$ photometry obtained with the telescopes of the Caucasian mountain observatory and analyse it together with the data acquired by the All Sky Automated Survey for SuperNovae. We report on the detection of multiperiod brightness variability caused by pulsations. A beating of close periods, the main one of 73 days and additional ones of 68 and 70 days, leads to amplitude variations. We have also detected a long-term sine trend in brightness with a period of nearly 1800 days. We suppose it to be orbital and IRAS 07253-2001 to be binary. Based on new low-resolution spectroscopic data obtained with the 2.5-m telescope of the Caucasian mountain observatory in 2020 and 2023 in the $\lambda$3500-7500 wavelength range we have identified spectral lines and compiled a spectral atlas. We have found the [N II], [Ni II] and [S II] forbidden emission lines in the spectrum and discuss their origin. The H$\alpha$ line has a variable double-peaked emission component. We have derived preliminary estimates of the star's parameters and detected a variation of radial velocity with a peak-to-peak amplitude of about 30 km s$^{-1}$.Comment: 19 pages, 11 figures, 6 tables, Table 2 is only available in electronic form, accepted to Astrophysical Bulleti

Debating capabilities of biochemical markers of liver function in patients with alcoholic liver cirrhosis

Introduction. The diagnosis of alcohol-related liver disease is limited by the lack of a tool to reliably identify whether the present deterioration in the patient’s condition is due to alcohol consumption or other causes.Purpose. to conduct a comparative assessment of the clinical and diagnostic significance of liver function biochemical indicators (AST, ALT, GGT, ALP) and their calculated derivatives (AST/ALT, GGT/ALP, GGT/GGTn, ALP/ALPn) as markers of alcohol consumption in patients with alcoholic liver cirrhosis.Material and methods. The observational study included 112 men over 18 years of age with alcohol-related liver cirrhosis. The patients were assessed the severity of liver cirrhosis according to the Child-Pugh scale, performed general and biochemical blood tests, coagulation test, assessment of the fact of alcohol consumption by the level of phosphatidylethanol. An analysis was made of the relationship between alcohol consumption and changes in laboratory parameters of liver function, with the determination of their sensitivity and specificity.Results. Patients with Child-Pugh B cirrhosis who consumed alcohol on phosphatidylethanol had higher levels of plasma albumin, GGT, and lower values of creatinine, direct and total bilirubin, urea, and aPTT compared with patients who did not drink alcohol (p < 0.05). Alcohol-drinking patients with class C cirrhosis have higher ALT levels compared with abstinent patients with the same severity of cirrhosis (p < 0.05). The relationship between the fact of alcohol consumption, determined by the level of phosphatidylethanol, and the ratio of GGT of patients to the normal GGT value, as well as between the ratio of GGT to alkaline phosphatase and the degree of increase in GGT, turned out to be statistically significant. To assess the fact of alcohol consumption, the level of serum GGT > 65 IU/ l (75.5%) has the highest sensitivity, the highest specificity is the ratio of the patient’s GGT to the normal value of GGT > 2 (82.9%).Conclusion. Compared with the known 100% sensitivity and > 92% specificity of Peth as a alcohol biomarker, among the biochemical indicators of liver function and their calculated derivatives, GGT > 65 IU/l have the greatest sensitivity or specificity (respectively, 75.5% and 65%) and GGTnorm. > 2 (37.7% and 82.9%, respectively), which makes it possible to use the totality of these parameters as an indicator of the continued impact on the patient of the main etiological factor of alcohol-related liver cirrhosis in the routine practice of most medical organizations of the Russian Federation

Pulsations and Long-Term Light Variability of Three Candidates to Protoplanetary Nebulae

We present new photometric data and analysis of the long-duration UBV photoelectric observations for three candidates to protoplanetary objects - F-supergiants with IR-excesses located at large galactic latitudes, IRAS 18095+2704, IRAS 19386+0155, and IRAS 19500-1709. All three stars have revealed quasiperiodic low-amplitude variabilities caused by pulsations observed against the long-term trends of brightnesses. For IRAS 18095+2704=V887 Her we have found a pulsation period of 109 days and a linear trend of brightness under the constant colours if being averaged over the year timescale. The light curve of IRAS 19386+0155=V1648 Aql over 2000-2008 can be approximated by a wave with a main period of 102 days which is modulated by close frequency, with a period of 98 days, that results in brightness oscillations with a variable amplitude. V1648 Aql has also shown synchronous reddening together with a persistent rise of brightness in the V-band. IRAS 19500-1709=V5112 Sgr experiences irregular pulsations with the periods of 39 and 47 days. The long-term component of the variability of V5112 Sgr may be related to the binary character of this star.Comment: 11 pages, 6 figures, accepted for publication in Pis'ma Astron. Z

Comparative characteristics and evaluation of the quality of cosmetic creams and ointments

The purpose of the study is to study the quality and comparative characteristics of cosmetic creams and ointments based on physical and chemical studies and determination of fat-soluble vitamins.Цель исследования – исследование качества и сравнительная характеристика косметических кремов и мазей на основе проведенных физико-химических исследований и определении жирорастворимых витаминов

A flare in the optical spotted in the changing-look Seyfert NGC 3516

We present observations from the short-term intensive optical campaign (from Sep2019 to Jan2020) of the changing-look Seyfert NGC 3516. This active galactic nucleus is known to have strong optical variability and has changed its type in the past. It has been in the low-activity state in the optical since 2013, with some rebrightening from the end of 2015 to the beginning of 2016, after which it remained dormant. We aim to study the photometric and spectral variability of NGC 3516 from the new observations in U- and B-bands and examine the profiles of the optical broad emission lines in order to demonstrate that this object may be entering a new state of activity. NGC 3516 has been monitored intensively for the past 4 months with an automated telescope in U and B filters, enabling accurate photometry of 0.01 precision. Spectral observations were triggered when an increase in brightness was spotted. We support our analysis of past-episodes of violent variability with the UV and X-ray long-term light curves constructed from the archival Swift data. An increase of the photometric magnitude is seen in both U and B filters to a maximum amplitude of 0.25mag and 0.1 mag, respectively. During the flare, we observe stronger forbidden high-ionization iron lines than reported before, as well as the complex broad Ha and Hb lines. This is especially seen in Ha which appears to be double-peaked. It seems that a very broad component of ~10,000 km/s in width in the Balmer lines is appearing. The trends in the optical, UV, and X-ray light curves are similar, with the amplitudes of variability being significantly larger in the case of UV and X-ray bands. The increase of the continuum emission, the variability of the coronal lines, and the very broad component in the Balmer lines may indicate that the AGN of NGC 3516 is finally leaving the low-activity state in which it has been for the last ~3 years.Comment: 7 pages, 6 figures, accepted in A&A (corrected after receiving comments from the language editor