2 research outputs found
Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots of <i>Panax japonicus</i>
Three new polyacetylenic oleanane-type
triterpenoids, baisanqisaponins
A–C (<b>1</b>–<b>3</b>), and one new oleanane-type
triterpenoid, chikusetsusaponin-V ethyl ester (<b>4</b>), together
with 19 known compounds (<b>5</b>–<b>23</b>), were
isolated from the roots of <i>Panax japonicus</i>. The structures
were elucidated on the basis of spectroscopic analyses and chemical
methods. Compounds <b>1</b>–<b>3</b> feature a
rare panaxytriol group containing a polyacetylene on the saponin skeleton.
Neuroprotective activity was evaluated for compounds <b>1</b>–<b>17</b>, and angiotensin II-induced vascular smooth
muscle cell proliferation inhibition was tested for compounds <b>5</b>–<b>7</b> and <b>10</b>–<b>12</b>
Two new bicyclic sesquiterpenes from the stems of <i>Kadsura heteroclita</i>
<div><p>Two new bicyclic sesquiterpenes, namely 6α,9α-dihydroxycadinan-4-en-3-one (<b>1</b>) and guai-3-en-10α-ol (<b>2</b>), together with one known sesquiterpene were isolated from the stems of <i>Kadsura heteroclita</i>, which is a Tujia ethnomedicine called ‘Xue Tong’. Their structures were elucidated by using spectroscopic analyses and by comparing the NMR data with those reported previously.</p></div