Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study

Ikeda, S, Ueda, Y, Hara, M, et al. Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case‐control study. Cancer Sci. 2020; 00: 1– 8. https://doi.org/10.1111/cas.14682

Genotype prevalence and age distribution of human papillomavirus from infection to cervical cancer in Japanese women: A systematic review and meta-analysis

Background: National HPV vaccination coverage in Japan is less than one percent of the eligible population and cervical cancer incidence and mortality are increasing. This systematic review and meta-analysis aimed to provide a comprehensive estimate of HPV genotype prevalence for Japan. Methods: English and Japanese databases were searched to March 2021 for research reporting HPV genotypes in cytology and histology samples from Japanese women. Summary estimates were calculated by disease stage from cytology only assessment – Normal, ASCUS, LSIL, HSIL and from histological assessment – CIN1, CIN2, CIN3/AIS, ICC (ICC-SCC, and ICC-ADC), and other. A random-effects meta–analysis was used to calculate summary prevalence estimates of any-HPV, high-risk (HR) and low-risk (LR) vaccine types, and vaccine genotypes (bivalent, quadrivalent, or nonavalent). This study was registered with PROSPERO: CRD42018117596. Results: A total of 57759 women with normal cytology, 1766 ASCUS, 3764 LSIL, 2017 HSIL, 3130 CIN1, 1219 CIN2, 869 CIN3/AIS, and 4306 ICC (which included 1032 ICC-SCC, and 638 ICC-ADC) were tested for HPV. The summary estimate of any-HPV genotype in women with normal cytology was 15·6% (95% CI: 12·3–19·4) and in invasive cervical cancer (ICC) was 85·6% (80·7–89·8). The prevalence of HR-HPV was 86·0% (95% CI: 73·9–94·9) for cytological cases of HSIL, 76·9% (52·1–94·7) for histological cases of CIN3/AIS, and 75·7% (68·0–82·6) for ICC. In women with ICC, the summary prevalence of bivalent vaccine genotypes was 58·5% (95% CI: 52·1–64·9), for quadrivalent genotypes was 58·6% (52·2–64·9) and for nonavalent genotypes was 71·5% (64·9–77·6), and of ICC cases that were HPV positive over 90% of infections are nonavalent vaccine preventable. There was considerable heterogeneity in all HPV summary estimates and for ICC, this heterogeneity was not explained by variability in study design, sample type, HPV assay type, or HPV DNA detection method, although studies published in the 1990s had lower prevalence estimates of any-HPV and HR HPV genotypes. Interpretations: HPV prevalence is high among Japanese women. The nonavalent vaccine is likely to have the greatest impact on reducing cervical cancer incidence and mortality in Japan

Epidemiologic profile of type-specific human papillomavirus infection after initiation of HPV vaccination

Funding Information: This work was supported by the Health and Labor Sciences Research Grant [26272001] and the Japanese Agency for Medical Research and Development [JP15ck0106103]. Acknowledgments: We would like to thank Yuka Watanabe, Sachiko Ono, Anna Ishida, Yoko Motoki and the administrator of Niigata city for their support in conducting the surveyPeer reviewedPublisher PD

Japan's Ongoing Crisis on HPV Vaccination.

Funding: This work was supported by the Health and Labor Sciences Research Grant [26272001] and the Japanese Agency for Medical Research and Development [JP15ck0106103]. Acknowledgments: We would like to thank Yuka Watanabe, Sachiko Ono, Anna Ishida, Yoko Motoki, Tomomi Egawa-Takata, Akiko Morimoto, Yusuke Tanaka and the administrator of Niigata city for their support in conducting the surveyPeer reviewedPublisher PD

Dietary acrylamide intake and the risk of liver cancer: The japan public health center-based prospective study

Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 μg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 μg/day) was 0.79 (95% confidence interval [CI] = 0.65-0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87-1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population.Zha, L.; Sobue, T.; Kitamura, T.; Kitamura, Y.; Ishihara, J.; Kotemori, A.; Liu, R.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S.; JPHC Study Group, f.t. Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study. Nutrients 2020, 12, 2503. https://doi.org/10.3390/nu1209250

Long-term effectiveness of HPV vaccination against HPV infection in young Japanese women : Real-world data.

ACKNOWLEDGEMENTS We would like to thank Ms. Yuka Watanabe, Ms. Sachiko Ono, Ms. Anna Ishida, and the administrator of Niigata city for their support in conducting the surveyPeer reviewedPublisher PD

Long-Term Effects of Human Papillomavirus Vaccination in Clinical Trials and Real-World Data : A Systematic Review

Peer reviewedPublisher PD

Effectiveness of human papillomavirus vaccine against cervical precancer in Japan : Multivariate analyses adjusted for sexual activity.

ACKNOWLEDGMENTS We would like to thank Mr Kenshin Sekine and Mr Taishin Sekine for English editing, and Ms Yuka Watanabe, Ms Sachiko Ono, Ms Anna Ishida, and administrators of Niigata, Nagaoka, Joetsu, Shibata, Sanjo, Mitsuke city for their support in conducting the survey.Peer reviewedPublisher PD

Effectiveness of catch-up and routine program of the 9-valent vaccine on cervical cancer risk reduction in Japan

Yagi A., Nakagawa S., Ueda Y., et al. Effectiveness of catch-up and routine program of the 9-valent vaccine on cervical cancer risk reduction in Japan. Cancer Science 115, 916 (2024); https://doi.org/10.1111/cas.16055.In 2013, the national human papillomavirus (HPV) immunization program began. However, in June 2013, Japan's Ministry of Health, Labor and Welfare (MHLW) announced a “temporary” suspension of its recommendation for the human papillomavirus vaccine. Finally, in November 2021, the MHLW ended its suspension of the recommendation of the HPV vaccine. To address the 9-year gap in HPV vaccinations the suspension had caused, the MHLW conducted a program of catch-up vaccinations from April 2022 to March 2025. Finally, in April 2023, the 9-valent HPV vaccine was approved for both the routine and catch-up vaccination programs in Japan. In this study, we investigated the potential effects of the introduction of the 9-valent vaccine on the increased risk of cervical cancer in females born after fiscal year (FY) 2000. We estimated the lifetime relative risk of cervical cancer incidence and death using the improved routine and catch-up vaccination rates after the recent resumption of the governmental recommendation for women and girls to have the HPV vaccination. These relative risks were calculated using a lifetime risk of 1.000 for cervical cancer incidence and death for females born in FY 1993. We predicted that even if a 90% vaccination rate were to be achieved by FY 2024 with the 9-valent vaccine among women born between FY 2000 and FY 2005, the risk would remain higher than for the vaccination generation. Therefore, for women born between FY 2000 and FY 2005, it will be necessary to significantly improve the cervical cancer screening rate to compensate for this increased risk

エアロビックダンスが心理的側面に与える影響(人間学部 , 聖泉大学)

本研究は,エアロビックダンスの授業が心理的側面にどのような影響を与えるのかを明らかにすることを目的とし,POMS,疲労の自覚症状,授業後の感想を用いて検討した。その結果,エアロビックダンス授業後は授業前に比べ,情緒が安定し,疲労が軽減されることが明らかになった。また,授業後の感想から,エアロビックダンスをすることにより,1.すっきりする,ストレスが解消される,2.身体に対するコントロール感を獲得する,3.日常生活や健康について考える,4.達成感が得られることが示唆された