Attenuation of guanine oxidation via DNA-mediated electron transfer in a crowded environment using small cosolutes

Guanine oxidation induced by photoirradiation on a pyrene-modified oligonucleotide was investigated under molecular crowding using small cosolutes such as glycerol. The efficiency of guanine photooxidation was suppressed in accordance with the increase in the concentration of glycerol. The results of photooxidation experiments using fully matched and mismatched DNA showed that guanine decomposition was mainly caused by DNA-mediated electron transfer (ET) in glycerol mixed solutions, as well as in diluted aqueous buffer solutions. Multiple factors can contribute to the suppression of guanine oxidation in crowded environments. However, our experimental results indicated that the attenuation of the DNA-mediated ET process suppressed guanine oxidation. On the other hand, experiments using ethylene glycol showed that guanine decomposition efficiency varies depending on the surrounding solvent. These results suggested that changes in the characteristics of the surrounding medium affect the DNA fluctuation, dominating DNA-mediated ET

Constructing A Business Process Network System A-BPNS-NPD

The authors came up with Amasaka laboratorys Business Process Network System for New Product Developments - A-BPNS-NPD - a business process network system that supports improvements in the way businesses approach new product development. Specifically, it is a core system with four components, each of which is designed to clarify the unspoken business processes that companies use in new product development. The first component is a support system for visualizing business processes. The second is a support system for better planning. The third is a support system for work progress management, which includes a support system for passing on know-how and for expansion and growth. The fourth component is a new product development business process approach model to help companies systematically put the other components into action. The A-BPNS-NPD developed by the authors was verified at manufacturing companies and the desired results were obtained

A Study On Effectiveness Of Movie Trailers Boosting Customers Appreciation Desire: A Customer Science Approach Using Statistics And GSR

In this study, the authors research Effectiveness of Movie Trailers Boosting Customers Appreciation Desire using statistical science and GSR (Galvanic Skin Response) data. As a result of this study, the authors suggest two models of movie trailers boosting customers appreciation desire to make a new movie trailer

A Face-like Structure Detection on Planet and Satellite Surfaces using Image Processing

This paper demonstrates that face-like structures are everywhere, and can be de-tected automatically even with computers. Huge amount of satellite images of the Earth, the Moon, the Mars are explored and many interesting face-like structure are detected. Throughout this fact, we believe that science and technologies can alert people not to easily become an occultist.Comment: 4 page

Extensive Preferential Pathway Ablation for the Elimination of Premature Ventricular Contractions Arising from the Right Ventricular Outflow Tract

AbstractA 76 y/o women presented with 2 different types of premature ventricular contractions (VPCs 1 and 2) arising from the right ventricular outflow tract (RVOT). Catheter ablation (CA) eliminated PVC1 at the earliest activation site (EAS), but thereafter another PVC morphology (PVC3) appeared. Small potentials preceding the local potential were broadly exhibited from the RVOT’s supero-anterior region to the EAS during PVC3. Point CA targeting such prepotentials failed. Transverse-linear CA with a line connecting sites with such pre-potentials eliminated both PVCs 3 and 2. In cases with broadly spreading preferential pathways, extensive CA might be needed to eliminate the PVCs

Coupling of codoped In and N impurities in ZnS:Ag: Experiment and theory

A vapor-phase-grown epitaxial ZnS:Ag layer simultaneously codoped with In and N on GaAs substrate exhibited a 436-nm light emission and p-type conduction with a low resistivity. X-ray photoemission spectroscopy revealed that the In 3d5/2 electron binding energy of the codoped ZnS:In,N layer was smaller by 0.5 eV than that of the ZnS:In independently doped layer, although the 2p3/2 electron binding energies of Zn and S of the codoped layer agreed well with those of the independently doped layer, respectively. The reduction of binding energy was ascribed to an increase in the electronic relaxation energy for core-hole states in photoemission and reflects a large charge transfer between the In and N atoms at the first neighbor sites through covalent sp3 bonding orbitals. An increase of the spectral intensity at around 4 eV relative to the valence band maximum observed for the codoped layer corresponds to a new state at –3.67 eV from the valence band maximum due to a strong coupling between the In 5s and N 2p orbitals at the first neighbor sites, derived from a first-principle band structure calculation for ZnS:(In,2N)

骨格内ヘテロ金属及び結晶内ナノクラスターを有するゼオライトの新規調製法の開発

学位の種別: 課程博士審査委員会委員 : （主査）東京大学准教授 脇原 徹, 東京大学教授 堂免 一成, 東京大学教授 S. Ted Oyama, 東京大学教授 小倉 賢, 横浜国立大学教授 窪田 好浩University of Tokyo(東京大学

Hyperreactivity to weak acoustic stimuli and prolonged acoustic startle latency in children with autism spectrum disorders

BACKGROUND: People with autism spectrum disorders (ASD) are known to have enhanced auditory perception, however, acoustic startle response to weak stimuli has not been well documented in this population. The objectives of this study are to evaluate the basic profile of acoustic startle response, including peak startle latency and startle magnitude to weaker stimuli, in children with ASD and typical development (TD), and to evaluate their relationship to ASD characteristics. METHODS: We investigated acoustic startle response with weak and strong acoustic stimuli in 12 children with ASD and 28 children with TD, analyzing the relationship between startle measures and quantitative autistic traits assessed with the Social Responsiveness Scale (SRS). The electromyographic activity of the left orbicularis oculi muscle to acoustic stimuli of 65 to 115 dB sound pressure level (SPL), in increments of 5 dB, was measured to evaluate acoustic startle response. The average eyeblink magnitude for each acoustic stimuli intensity and the average peak startle latency of acoustic startle response were evaluated. RESULTS: The magnitude of the acoustic startle response to weak stimuli (85 dB or smaller) was greater in children with ASD. The peak startle latency was also prolonged in individuals with ASD. The average magnitude of the acoustic startle response for stimulus intensities greater than 85 dB was not significantly larger in the ASD group compared with the controls. Both greater startle magnitude in response to weak stimuli (particularly at 85 dB) and prolonged peak startle latency were significantly associated with total scores, as well as several subscales of the SRS in the whole sample. We also found a significant relationship between scores on the social cognition subscale of the SRS and the average magnitude of the acoustic startle response for stimulus intensities of 80 and 85 dB in the TD group. CONCLUSIONS: Children with ASD exhibited larger startle magnitude to weak stimuli and prolonged peak startle latency. These startle indices were related to several characteristics of ASD. A comprehensive investigation of acoustic startle response, including the magnitude of startle responses to weak stimuli and peak startle latency, might further our understanding of the neurophysiological impairments underlying ASD