INSECURITY AND THE PAUPERIZATION OF RESIDENTS OF OWERRI IN IMO STATE, NIGERIA: AN EMPIRICAL ASSESSMENT

Poverty and insecurity are twin recurrent issues in recent times for many countries in the world, especially Third World countries in Africa to which Nigeria belongs. Security is a pillar without which no meaningful development can be achieved and sustained. Nigeria, like most other Sub-Sahara Africa countries, is deeply embroiled in and facing multifaceted security challenges. The wave of insecurity in Nigeria has assumed a dangerous dimension that is threatening both the safety of environment for lives and properties and the conduct of business and economic activities thereby causing untold hardship and poverty. The poverty level in Nigeria is such that many people now live below the poverty line and has become a source of concern and subject of growing attention for both academics and policy makers. This paper, therefore, sought to find out if insecurity has a causative effect on the pauperization of the people of Owerri and vice versa with particular reference to recent happenings in Owerri, Imo State, Nigeria. The survey research design, questionnaire and interviews as instruments of primary data collection and relative deprivation theory as framework were used for the study. Data were analysed with simple percentages while the chi-square was used to test the hypothesis. Secondary data from library research was utilized for analytical discussion. Research findings show that insecurity has both a cause and an effect relationship with poverty cum pauperization and the need to shun violence is recommended.  Article visualizations

A Mouse Holder for Awake Functional Imaging in Unanesthetized Mice: Applications in ³¹P Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, and Resting-State Functional Magnetic Resonance Imaging

Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies in awake, unanesthetized animals to obtain accurate results without the confounding physiological effects of anesthesia. Here, we describe a newly designed mouse holder that is interfaceable with existing MRI systems and enables awake in vivo mouse imaging. This holder significantly reduces head movement of the awake animal compared to previously designed holders and allows for the acquisition of improved anatomical images. In addition to applications in anatomical T2-weighted magnetic resonance imaging (MRI), we also describe applications in acquiring 31P spectra, manganese-enhanced magnetic resonance imaging (MEMRI) transport rates and resting-state functional magnetic resonance imaging (rs-fMRI) in awake animals and describe a successful conditioning paradigm for awake imaging. These data demonstrate significant differences in 31P spectra, MEMRI transport rates, and rs-fMRI connectivity between anesthetized and awake animals, emphasizing the importance of performing functional studies in unanesthetized animals. Furthermore, these studies demonstrate that the mouse holder presented here is easy to construct and use, compatible with standard Bruker systems for mouse imaging, and provides rigorous results in awake mice