Additional file 1: Figure S1. of The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

Effects of TSA on important cell cycle regulators. Densitometric analysis of Western blots. TSA induced the expression of p21, p27 and p53 in a concentration-dependent manner. LECs that were left untreated (solvent only) or were treated with TSA in a concentration-dependent manner for 24 h as indicated. The western blot bands were quantified by densitometry; absorbencies of p21, p27 and p53 bands were corrected for loading differences based on the corresponding tubulin bands. Experiments were performed at least three times, and the results are shown as mean ± SD. *p < 0.05 vs ctrl., ns = not significant. (JPG 28 kb