5 research outputs found
Mechanically Planar-to-Point Chirality Transmission in [2]Rotaxanes
© 2024. The authors. This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/
This document is the published version of a published work that appeared in final form in Journal of the American Chemical Society (JACS).
To access the final work, see DOI: https://doi.org/10.1021/jacs.3c11611Herein we describe an effective transmission of chirality, from mechanically planar chirality to point chirality, in
hydrogen-bonded [2]rotaxanes. A highly selective mono-N-methylation of one (out of four) amide N atom at the macrocyclic
counterpart of starting achiral rotaxanes generates mechanically planar chirality. Followed by chiral resolution, both enantiomers
were subjected to a base-promoted intramolecular cyclization, where their interlocked threads were transformed into new lactam
moieties. As a matter of fact, the mechanically planar chiral information was effectively transferred to the resulting stereocenters
(covalent chirality) of the newly formed heterocycles. Upon removing the entwined macrocycle, the final lactams were obtained with
high enantiopurity
Synthesis and Characterization of Axially Chiral Imidazoisoquinolin-2-ylidene Silver and Gold Complexes
The selective Suzuki cross-coupling
of 1,3-dichloroisoquinoline
with 2-substituted 1-naphthylboronic acids/esters followed by construction
of the imidazo[1,5-<i>b</i>]isoquinoline ring and alkylation
constitutes a straightforward route to imidazolium salts fused into
an axially chiral biaryl skeleton. Metalation of these azolium salts
afforded the corresponding NHC silver complexes, which were used as
carbene transfer agents for the synthesis of Au(I) derivatives
Mechanically Planar-to-Point Chirality Transmission in [2]Rotaxanes
Herein we describe an effective transmission of chirality,
from
mechanically planar chirality to point chirality, in hydrogen-bonded
[2]rotaxanes. A highly selective mono-N-methylation of one (out of
four) amide N atom at the macrocyclic counterpart of starting achiral
rotaxanes generates mechanically planar chirality. Followed by chiral
resolution, both enantiomers were subjected to a base-promoted intramolecular
cyclization, where their interlocked threads were transformed into
new lactam moieties. As a matter of fact, the mechanically planar
chiral information was effectively transferred to the resulting stereocenters
(covalent chirality) of the newly formed heterocycles. Upon removing
the entwined macrocycle, the final lactams were obtained with high
enantiopurity
Synthesis and Characterization of Axially Chiral Imidazoisoquinolin-2-ylidene Silver and Gold Complexes
The selective Suzuki cross-coupling
of 1,3-dichloroisoquinoline
with 2-substituted 1-naphthylboronic acids/esters followed by construction
of the imidazo[1,5-<i>b</i>]isoquinoline ring and alkylation
constitutes a straightforward route to imidazolium salts fused into
an axially chiral biaryl skeleton. Metalation of these azolium salts
afforded the corresponding NHC silver complexes, which were used as
carbene transfer agents for the synthesis of Au(I) derivatives
Axially Chiral Triazoloisoquinolin-3-ylidene Ligands in Gold(I)-Catalyzed Asymmetric Intermolecular (4 + 2) Cycloadditions of Allenamides and Dienes
The first highly enantioselective intermolecular (4 +
2) cycloaddition
between allenes and dienes is reported. The reaction provides good
yields of optically active cyclohexenes featuring diverse substitution
patterns and up to three stereocenters. Key to the success of the
process is the use of newly designed axially chiral <i>N</i>-heterocyclic carbene–gold catalysts