Reaction of Glyconitriles with Organometallic Reagents: Access to Acyl β‑<i>C</i>‑Glycosides

A new strategy for the synthesis of acyl β-<i>C</i>-glycosides is described. The reactivity of glyconitriles toward organometallic reagents such as organomagnesium or organolithium derivatives was studied, affording acyl β-<i>C</i>-glycosides in moderate to good yields. In this study, glycal formation was efficiently prevented by deprotonating the hydroxyl group in position 2 of the glyconitriles during the process