27 research outputs found
Demographic and clinical characteristics of patients with venous thromboembolism (VTE) and control subjects.
<p>Demographic and clinical characteristics of patients with venous thromboembolism (VTE) and control subjects.</p
<i>LPA</i> KIV-2 repeats in VTE patients.
<p><i>LPA</i> KIV-2 repeats in VTE patients.</p
Genotype distribution and minor allele frequency of the 4 <i>LPA</i> single nucleotide polymorphisms (SNPs) investigated.
<p>Genotype distribution and minor allele frequency of the 4 <i>LPA</i> single nucleotide polymorphisms (SNPs) investigated.</p
Characteristics of the 4 selected <i>LPA</i> gene single nucleotide polymorphisms (SNPs).
<p>Characteristics of the 4 selected <i>LPA</i> gene single nucleotide polymorphisms (SNPs).</p
Correlation between ΔΔCt and absolute number of DNA copies of LPA exon 4.
<p>The C27 sample, previously predicted to have 27 DNA copies of this region, has been used as reference.</p
Receiver operating characteristic curve for association with venous thromboembolism in the whole population.
<p>Variables included in the models: Genetic = KIV-2 repeats; Clinical = age, sex, hypertension, smoking habit, dyslipidemia, diabetes, BMI, hyperhomocysteinemia, and oral contraceptives/HRT; Combined = Genetic + Clinical variables.</p
Association between KIV-2 repeat quartiles (Q1: ≤7 repeats; Q2: 8–12 repeats; Q3: 13–22 repeats; Q4: ≥23 repeats) and venous thromboembolism.
<p>Multivariate logistic regression analysis: adjusted for age, sex, hypertension, smoking habit, dyslipidemia, diabetes, BMI, hyperhomocysteinemia and oral contraceptives/HRT; Q4: reference group.</p
Quantile-Quantile (QQ) plot of p-value distributions for A. common and low-frequency variants (MAF > 1%) and B. rare variants (MAF ≤ 1%).
<p>An arrow indicates the rs2232710 variant.</p
Association results of the 18 variants identified in the NGS and replicated in up to 585 idiopathic DVT patients and 550 healthy controls from the DVT-Milan study.
<p>Analysis was performed using chi-squared test.</p
Replication analysis of the rs2232710 (<i>SERPINA10/ZPI</i> gene) single nucleotide variant in patients with idiopathic deep vein thrombosis of lower extremities and heathy controls belonging to three independent cohorts: DVT-Milan, LETS and MEGA.
<p>Analysis was performed using chi-squared test.</p