Study protocol: effort-reward imbalance at work and risk of type 2 diabetes - a prospective study linking survey and register data

<div><b>Abstract</b><br></div><div><br></div><div><b>Background:</b> Diabetes is a growing public health concern. Psychosocial factors at work might be associated with an increased risk of developing type 2 diabetes. One hypothesised mechanism is stress stimulated cortisol release via the HPA-axis, where cortisol is involved in blood glucose regulation. High levels of blood glucose lead to secretion of insulin to the blood and if this continues, insulin resistance might develop, which is associated with the development of type 2 diabetes. Other possible pathways might be via associations of psychosocial work factors with 1) adverse health-related behaviour such as physical inactivity, and 2) psycho-physiological disturbances associated with overweight and metabolic changes. However, the current research on the relationship between psychosocial work factors and type 2 diabetes is inconclusive. <br></div><div><br></div><div><b>Objective:</b> This protocol describes the planned analyses for a study aiming to investigate the prospective association of effort-reward imbalance at work and its sub-dimensions with the risk of developing type 2 diabetes. <br></div><div><br></div><div><b>Methods:</b> The population under study is a sample of workers in Denmark from the biennial survey “Work Environment and Health in Denmark 2012-2020”. We include approximately 50,000 participants aged 30-64 years. The participants are linked to and followed in national registers. We will apply Cox proportional hazards models to study the prospective association of effort-reward imbalance with risk of type 2 diabetes with adjustment for a range of demographic and social determinants. <br></div><div><br></div><div><b>Discussion:</b> We expect that this study will expand the current knowledge about the potential impact of psychosocial work factors on the risk of developing type 2 diabetes. </div

Study protocol for analyses on the prospective association of work-related violence, and decision latitude with risk of depression in The Danish Work Life Course Cohort (DAWCO)

This protocol describes planned analyses on the longitudinal associations of work-related violence and decision latitiude with risk of clinical depression. The protocol gives details of the planned analyses to avoid post hoc decision making in the analysis of the data

Study protocol: Job strain as a predictor of depressive symptoms - assessing interaction between job demands and job control and examining effect modification by co-existing mental and somatic disorders and low socioeconomic status

This study protocol describes planned analyses to examine the association between job strain and depressive symptoms, with a particular focus on interactions with potential vulnerability factors outside the work environment