Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentration

XXiVth CINP congress Pari

5-HT2 receptor bindings in patients with bipolar disorder: a positron emission tomography study with [11C]NMSP

XXIVth CINP congress Pari

Time course of the extrastiatal dopamine D2 receptor occupancy by resperidone

XXXIII CINP Congres

Effects of smoking on the lung accumulation of [11C]McN5652

Objective The lung is one of the key organs for determiningthe distribution of drugs in the human body.Various factors infl uence the accumulation of drugs. Inthis study, we investigated the effects of smoking on drugdistribution to the lung using radiolabeled drugs.Methods We measured the lung uptake of [11C](+)McN5652, a radioligand for serotonin transporter(5-HTT), and inactive enantiomer [11C](−)McN5652 in19 healthy men (12 nonsmokers and 7 smokers) usingpositron emission tomography. Pretreatment study wasperformed by the administration of clomipramine(50 mg), a potent 5-HTT inhibitor.Results The mean lung uptake of [11C](+)McN5652 and[11C](−)McN5652 was signifi cantly higher in smokersthan in nonsmokers. The lung uptake of [11C](+)McN5652decreased after pretreatment with clomipramine, whereasthat of [11C](−)McN5652 was not affected byclomipramine.Conclusions Lung uptake of [11C](−)McN5652 wasin fl uenced by smoking, possibly because the probablenonspecifi c binding accumulation was changed as [11C](−)McN5652 was reported to have negligible affi nity to5-HTT. Smoking might be one of the important factorswhen distribution of radioligands is considere

Neurorecepter Imaging of Epilepsy and Related Psychiatry Symptoms

XII World Congress of Psychiatr