21 research outputs found
Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice
Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus
There is a close relationship between diabetes mellitus and heart failure, and diabetes is an independent risk factor for heart failure. Diabetes and heart failure are linked by not only the complication of ischemic heart disease, but also by metabolic disorders such as glucose toxicity and lipotoxicity based on insulin resistance. Cardiac dysfunction in the absence of coronary artery disease, hypertension, and valvular disease is called diabetic cardiomyopathy. Diabetes-induced hyperglycemia and hyperinsulinemia lead to capillary damage, myocardial fibrosis, and myocardial hypertrophy with mitochondrial dysfunction. Lipotoxicity with extensive fat deposits or lipid droplets is observed on cardiomyocytes. Furthermore, increased oxidative stress and inflammation cause cardiac fibrosis and hypertrophy. Treatment with a sodium glucose cotransporter 2 (SGLT2) inhibitor is currently one of the most effective treatments for heart failure associated with diabetes. However, an effective treatment for lipotoxicity of the myocardium has not yet been established, and the establishment of an effective treatment is needed in the future. This review provides an overview of heart failure in diabetic patients for the clinical practice of clinicians
Delayed and Sudden Lymphocyte Recovery Is the Predictive Sign of Primary Graft Failure Following CBT, Single Institute Analysis of 105 CBT
NaxCoO2 with nano-sized pores / Pressure induced structural transition of SrCu2O3 (SOLID STATE CHEMISTRY - Multicomponent Materials)
NaxCoO2 with nano-sized pores/ Pressure induced structural transition of SrCu2O3 (SOLID STATE CHEMISTRY - Multicomponent Materials)
Regulation of Serum Thrombopoietin Levels by Platelets and Megakaryocytes in Patients with Aplastic Anaemia and Idiopathic Thrombocytopenic Purpura
Reversible Three-Electron Redox Reaction of Mo<sup>3+</sup>/Mo<sup>6+</sup> for Rechargeable Lithium Batteries
To
increase the energy density of lithium batteries, the development
of high-capacity positive electrode materials is essential. Herein,
we propose the use of a three-electron redox reaction of Mo<sup>3+</sup>/Mo<sup>6+</sup> for a new series of high-capacity lithium insertion
materials. In this study, a binary system of LiMoO<sub>2</sub>–Li<sub>3</sub>NbO<sub>4</sub> is targeted, and nanosize and metastable Li<sub>9/7</sub>Nb<sub>2/7</sub>Mo<sub>3/7</sub>O<sub>2</sub> is successfully
prepared by a mechanical milling process. The sample delivers a large
reversible capacity of ∼280 mAh g<sup>–1</sup> in a Li cell with good capacity retention. On the basis of these
results, the future possibility of high-capacity electrode materials
with a three-electron Mo<sup>3+</sup>/Mo<sup>6+</sup> redox reaction
is discussed