Supporting the vital role of boundary-spanning physician researchers in the advancement of medical innovation

A wide range of stakeholders recognise that physicians play a vital role in medical innovation and, in particular, the importance of boundary-spanning engagement between physicians and industry in clinical research. While UK physicians are keen to take part in research, this article draws on a range of literature to identify apparent and anticipated challenges that discourage or prevent cross-sector engagement by physician researchers. To encourage greater interaction and exploration of associated support mechanisms, we present a full spectrum of engagement modes, funding opportunities and illustrative initiatives, showing how different stakeholders (from government institutions, charities, professional bodies and industry) can contribute to improving the engagement of physicians in boundary spanning research. We emphasise the importance of mutual understanding, trust and commonly shared practices, as well as adequate resources, to encourage these vital interactions

Redecentralizing the Web with Distributed Ledgers

International audienceThe web was originally conceived as decentralized and universal, but during its popularization, its big value was built on centralized servers and nonuniversal access. A key element to redecentralize the web is to be able to generate trustable, secure, and accountable updates among autonomous participants without a central server. The authors believe that the marriage between distributed ledgers and linked data can provide this functionality and unlock the web's true potential. As a first step toward it, the authors propose a minimal vocabulary to describe and link distributed ledgers

Parkin Deficiency Delays Motor Decline and Disease Manifestation in a Mouse Model of Synucleinopathy

In synucleinopathies, including Parkinson's disease, partially ubiquitylated α-synuclein species phosphorylated on serine 129 (PS129-α-synuclein) accumulate abnormally. Parkin, an ubiquitin-protein ligase that is dysfunctional in autosomal recessive parkinsonism, protects against α-synuclein-mediated toxicity in various models

Engaging in open innovation through university-industry collaboration: lessons from a large pharmaceutical firm’s approach

EMBARGOED - expected end date 10.01.202

Organic nanocrystals confined in sol-gel matrix for bio-sensing and bio-imaging

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Molecular nanocrystals confined in silicate nanoparticles for medical imaging.

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Core-shell hybrid nanoparticles for bio-photonics : fluorescent organic nanocrystals grown in silicate sphères.

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Molecular nanocrystals confined in silicate nanoparticles: a new family of ultrabright fluorescent tracers for biophotonics.

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Fluorescent organic nanocrystals confined in sol-gel matrices for bio-sensing and bio-imaging.

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Fluorescence molecular nanocrystals grown in sol-gel matrices for optics and biophotonics

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