Single gene/multiple phenotype association.

<p>This table shows single gene/multiple phenotype association. The first column represents the gene, the second column represents the CCA association value, the third column is the Fisher's combined association value and the fourth column the phenotypes associated. In parentheses is the single phenotype association value of each phenotype.</p><p>Single gene/multiple phenotype association.</p

Multiple gene/single phenotype association table.

<p>This table shows multiple gene/single phenotype association values. The first column is the phenotype, the second column is the CCA association value, the third column is Fisher's combined association value and the fourth column are the genes associated. In parentheses the single gene/single phenotype association value is given for each gene.</p><p>Multiple gene/single phenotype association table.</p

Single gene/single phenotype association.

<p>This table shows single phenotype/single genotype association gene-centered association value. The first column represents genes, the second column phenotypes, the third column represents the CCA association value and the fourth column is the Pubmed ID if the association has been previously reported.</p><p>Single gene/single phenotype association.</p

Multiple gene/multiple phenotype association table.

<p>This table shows multiple gene/multiple phenotypes association rules. The first column are the multiple genes, the second column the CCA association value and the third column the multiple phenotypes.</p><p>Multiple gene/multiple phenotype association table.</p

Number (%) and means (standard deviations) for demographics¹ and other co-variates by Genotype.

<p>¹Data shown is for all study participants who had an <i>APOE</i> genotype available and who completed the n-back testing session. Qualifications shown are British. O levels and CSEs were taken aged 16, A levels are taken aged 18. CSEs were a lower level of qualification than O levels, which were taken by those not expected to pass O levels.</p><p>Number (%) and means (standard deviations) for demographics<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0135894#t001fn001" target="_blank">¹</a> and other co-variates by Genotype.</p

Hive plot for single gene/single phenotype.

<p>The vertical axis represents the association value (higher, more association). The left axis represents phenotypes and the right axis represents genes. An interactive hive plot is published on the project webpage (<a href="http://pleioexp.epi.bris.ac.uk/cca/1gene1phenhive.html" target="_blank">http://pleioexp.epi.bris.ac.uk/cca/1gene1phenhive.html</a>).</p

Heatmap single gene/multiple phenotype.

<p>This figure shows the 22 most important association rules as columns in a heatmap. Note that only one member of the <i>UGT1A</i> family is listed and rules for the same gene are summarized in the same column.</p

Results of Transmission Disequilibrium Test Assessing Association between R125W Variant and Familial Obesity.

<p>Results of Transmission Disequilibrium Test Assessing Association between R125W Variant and Familial Obesity.</p

<i>TBC1D1</i> R125W Genotype Frequencies of Mothers in the ALSPAC Cohort according to Overweight and Obese status.

<p>Data are presented as mean (standard deviation), BMI – Body Mass Index.</p>*<p>Odd Ratios are calculated in comparison to lean subjects based on the additive model of inheritance.</p>**<p><b>The Bonferroni corrected p-value equivalent to 0.05 is 0.025.</b></p

Location of R125 in the homology model of human TBC1D1 PTB1.

<p>(A) Homology based model of TBC1D1 PTB domain (residues 13–161) predicted by Robetta server (<a href="http://robetta.bakerlab.org/" target="_blank">http://robetta.bakerlab.org/</a>). The R125 residue (red) is orientated towards the cleft formed between β5 and α2 (purple). (B) Solved structure of IRS-1 PTB domain (PDB ID: 1IRS, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0063897#pone.0063897-Zhou1" target="_blank">[47]</a>). The IL-4 phosphopeptide (red) lies within the cleft formed between the β5 and α2 (purple), a type I β turn redirects the peptide such that the phosphorylated Tyr (shown) is orientated towards the β6/β7 loop.</p