Information on genotyped and imputed SNPs.

*<p>The WHII study was typed at two centres with different array readers, which were compared and shown to be concordant.</p

Disease event definitions, incident and prevalent events by disease and medication use in the UCLEB consortium.

<p>Total incident CHD =  incident non-fatal MI or revascularization plus fatal CHD (ICD codes I20–I25, I516).</p><p>Total prevalent CHD  =  prevalent non-fatal MI or revascularization.</p><p>Total incident stroke  =  incident non-fatal stroke (ischaemic & haemorrhagic combined, but excluding TIA) plus fatal stroke (ICD codes I60×, I61×, I62, I629 I63×, I64× I65× I66×, I67, I672, I678, I679, I69×, G46×, G450, G451, G452, G453).</p><p>Total diabetes defined by a combination of self-report, medical history review, use of glucose lowering medication, or fasting glucose >7 mmol/L.</p>*<p>1958BC are currently undertaking case ascertainment.</p